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Heart procedure showdown: serpentine twist vs. guidewire for navigating artery curves

NCT ID NCT07707427

Knowledge-focused Sponsor: University Hospital of Patras Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 16, 2026 · Last updated Jul 17, 2026 · Updated 1 time

Summary

This study compares two methods for guiding catheters through loops and sharp bends in the arm arteries during coronary angiography or angioplasty. The 'Serpentine' technique uses controlled catheter rotation, while the standard method uses a flexible guidewire. Researchers will measure which technique succeeds more often, how long it takes, and safety outcomes in about 200 patients with challenging arm artery anatomy.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If one technique proves clearly better, it could become the standard method for handling difficult arm artery anatomy during heart procedures, potentially reducing complications and procedure time.
What could go wrong
This is a small, single-center study comparing two established techniques, so the results may not apply broadly. Neither technique is new, so the impact is likely incremental.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 204 people

The number the study aims to enrol. It can still change while the study runs.

Started

May 2026

Expected to finish

Nov 2029

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age ≥18 years * Feasibility of TRA * Indication for coronary angiography * Angiographic documentation of radial or brachial artery loop/tortuosity * Written informed consent Exclusion Criteria: * STEMI - high risk NSTEMI presentation * Hemodynamic instability * Anatomical contraindications (e.g., arteriovenous fistula) * Significant calcification of the radial or brachial artery on angiographic evaluation.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Complex radial anatomy Coronary angiography (CAG) Coronary catheterization Hydrophilic guidewire Percutaneous coronary intervention (PCI) Radial artery loop Radial artery tortuosity Serpentine technique Transradial access(TRA) Vascular complications

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • University Hospital of Patras

    RECRUITING

    Pátrai, 26504, Greece

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