Diet and drug combo aim to tame tumor side effects

NCT ID NCT05300048

Terminated Disease control Sponsor: Faeth Therapeutics Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested a new drug called serabelisib combined with a diet that lowers insulin levels, with or without another chemotherapy drug, in people with advanced solid tumors that have a specific genetic change (PIK3CA mutation). The goal was to see if the diet could reduce side effects and improve how well the drug works. The study was stopped early, and only 34 people were enrolled.

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Conditions

The condition(s) this trial relates to.

colorectal adenocarcinoma endometrium adenocarcinoma neoplasm ovarian clear cell cancer ovarian endometrioid adenocarcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADVANCED SOLID TUMOR PIK3CA MUTATION PTEN LOSS OF FUNCTION MUTATION

Contacts and locations

Locations

Avera Cancer Institute

Sioux Falls, South Dakota, 57105, United States
Baptist Hospitals of Southeast Texas

Beaumont, Texas, 77701, United States
Community Health Network, Inc.

Indianapolis, Indiana, 46250, United States
East Carolina University

Greenville, North Carolina, 27858, United States
Englewood Health

Englewood, New Jersey, 07631, United States
Hoag Memorial Hospital Presbyterian

Newport Beach, California, 92663, United States
Lumi Research

Kingwood, Texas, 77339, United States
Mayo Clinic - Rochester

Rochester, Minnesota, 55902, United States
Medical College of Wisconsin

Milwaukee, Wisconsin, 53226, United States
Memorial Sloan Kettering Cancer Center

New York, New York, 10065, United States
New Jersey Cancer Care, PA

Belleville, New Jersey, 07109, United States
Northwell Health

Lake Success, New York, 11042, United States
Oncology Consultants, PA

Houston, Texas, 77030, United States
Pacific Cancer Specialists

Anaheim, California, 92801, United States
University of Alabama

Birmingham, Alabama, 35429, United States
University of Pennsylvania Health System, Perelman Center for Advanced Medicine

Philadelphia, Pennsylvania, 19104, United States
Valkyrie Clinical Trials

Los Angeles, California, 90067, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.