New drug cocktail aims to tackle KRAS lung cancer

NCT ID NCT01933932

Ongoing Disease control Sponsor: AstraZeneca Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This phase 3 trial tests whether adding selumetinib (a targeted therapy) to standard chemotherapy (docetaxel) helps people with advanced KRAS-mutant lung cancer live longer without their cancer growing. About 510 adults whose cancer worsened after first treatment will receive either the combo or a placebo plus chemo. The study measures progression-free survival, overall survival, and side effects.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

Selumetinib (a targeted cancer drug) combined with docetaxel (chemotherapy)

What this could lead to

If successful, this combination could offer a new treatment option for people with a specific type of advanced lung cancer (KRAS mutation) that has stopped responding to initial therapy.

What could go wrong

This is a late-stage trial, but the drug combination may not improve survival or could cause significant side effects like infections or fatigue. Results may not apply to all lung cancer patients.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

Neoplasm Metastasis non-small cell lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LOCALLY ADVANCED OR METASTATIC NON SMALL CELL LUNG CANCER STAGE IIIB - IV

Contacts and locations

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Locations

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Aurora, Colorado, 80045, United States
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Pembroke Pines, Florida, 33028, United States
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Atlanta, Georgia, 30318, United States
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Chicago, Illinois, 60637, United States
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Metairie, Louisiana, 70006, United States
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Boston, Massachusetts, 02114, United States
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Boston, Massachusetts, 02215, United States
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Danvers, Massachusetts, 01923, United States
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New York, New York, 10011, United States
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New York, New York, 10032, United States
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Durham, North Carolina, 27710, United States
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Hershey, Pennsylvania, 17033, United States
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Philadelphia, Pennsylvania, 19107, United States
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Nashville, Tennessee, 37203, United States
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Nashville, Tennessee, 37232, United States
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Seattle, Washington, 98104, United States
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Morgantown, West Virginia, 26506, United States
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Buenos Aires, 1426, Argentina
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Ciudad de Buenos Aires, 1180, Argentina
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Ciudad de Buenos Aires, C1025ABI, Argentina
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Córdoba, 5000, Argentina
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Rosario, S2000KZE, Argentina
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Camperdown, 2050, Australia
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Chermside, 4032, Australia
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Darlinghurst, 2010, Australia
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Fitzroy, 3065, Australia
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Kogarah, 2217, Australia
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Kurralta Park, 5037, Australia
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Malvern, 3144, Australia
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Wendouree, 3355, Australia
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Woodville South, 5011, Australia
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Innsbruck, 6020, Austria
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Linz, 4020, Austria
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Salzburg, 5020, Austria
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Vienna, 1100, Austria
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Vienna, 1160, Austria
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Brussels, 1000, Belgium
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Brussels, 1090, Belgium
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Brussels, 1200, Belgium
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Ghent, 9000, Belgium
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Leuven, 3000, Belgium
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Roeselare, 8800, Belgium
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Barretos, 14784-400, Brazil
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Ijuí, 98700-000, Brazil
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Pelotas, 096015-280, Brazil
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Porto Alegre, 90035-003, Brazil
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Porto Alegre, 90610-000, Brazil
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São José do Rio Preto, 15090-000, Brazil
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São Paulo, 01209-000, Brazil
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São Paulo, 01246-000, Brazil
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São Paulo, Brazil
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Plovdiv, 4000, Bulgaria
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Sofia, 1233, Bulgaria
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Sofia, 1303, Bulgaria
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Sofia, 1330, Bulgaria
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Varna, 9010, Bulgaria
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Vratsa, 3000, Bulgaria
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Edmonton, Alberta, T6G 1Z2, Canada
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Kelowna, British Columbia, V1Y 5L3, Canada
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Surrey, British Columbia, V3V 1Z2, Canada
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Halifax, Nova Scotia, B3H 1V7, Canada
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Oshawa, Ontario, L1G 2B9, Canada
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Toronto, Ontario, M5G 2M9, Canada
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Montreal, Quebec, H4A 3J1, Canada
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Québec, Quebec, G1V 4G5, Canada
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Regina, Saskatchewan, S4T 7T1, Canada
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Saskatoon, Saskatchewan, S7N 4H4, Canada
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Santiago, 7500921, Chile
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Santiago, 7520349, Chile
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Santiago, 7630370, Chile
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Santiago, 8360160, Chile
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Santiago, 8380456, Chile
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Santiago, 8420383, Chile
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Brest, 29609, France
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Caen, F-14033, France
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Clermont-Ferrand, 63003, France
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Dijon, 21079, France
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Lille, 59000, France
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Marseille, 13915, France
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Paris, 75020, France
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Pierre-Bénite, 69310, France
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Rennes, 35033, France
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Toulouse, 31059, France
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Augsburg, 86156, Germany
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Bad Berka, 99437, Germany
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Cologne, 50937, Germany
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Dortmund, 44309, Germany
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Gerlingen, 70839, Germany
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Großhansdorf, 22927, Germany
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Halle, 06120, Germany
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Heidelberg, 69126, Germany
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Homburg, 66424, Germany
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Löwenstein, 74245, Germany
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Moers, 47441, Germany
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München, 81925, Germany
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Ulm, 89081, Germany
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Wiesbaden, 65199, Germany
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Würzburg, 97080, Germany
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Budapest, 1121, Hungary
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Budapest, 1122, Hungary
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Edelény, 3780, Hungary
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Győr, 9024, Hungary
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Kaposvár, 7400, Hungary
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Miskolc, 3529, Hungary
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Nyíregyháza, 4400, Hungary
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Törökbálint, 2045, Hungary
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Beersheba, 8410101, Israel
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Haifa, 31096, Israel
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Kfar Saba, 4428164, Israel
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Petah Tikva, 49100, Israel
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Tel Aviv, 64239, Israel
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Tel Litwinsky, 52621, Israel
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Bari, 70124, Italy
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Genova, 16100, Italy
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Livorno, 57100, Italy
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Milan, 20132, Italy
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Naples, 80131, Italy
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Orbassano, 10043, Italy
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Parma, 43126, Italy
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Perugia, 06132, Italy
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Roma, 00128, Italy
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Roma, 00144, Italy
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México, 14080, Mexico
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Monterrey, 64460, Mexico
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's-Hertogenbosch, 5223 GZ, Netherlands
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Amsterdam, 1066 CX, Netherlands
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Amsterdam, 1081 HV, Netherlands
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Bergen op Zoom, 4624 VT, Netherlands
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Maastricht, 6202 AZ, Netherlands
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Lima, 15033, Peru
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Lima, 15073, Peru
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Lima, L27, Peru
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Lima, LIMA 01, Peru
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Lima, LIMA 11, Peru
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Lima, LIMA 29, Peru
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Lima, LIMA 34, Peru
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Miraflores, 15046, Peru
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Brzozów, 36-200, Poland
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Bydgoszcz, 85-796, Poland
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Gdansk, 80-219, Poland
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Gdansk, 80-952, Poland
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Grudziądz, 86-300, Poland
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Krakow, 31-202, Poland
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Lubin, 59-301, Poland
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Olsztyn, 10-357, Poland
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Opole, 45-061, Poland
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Sucha Beskidzka, 34-200, Poland
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Szczecin, 70-891, Poland
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Warsaw, 02-781, Poland
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Amadora, 2720-276, Portugal
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Coimbra, 3040-316, Portugal
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Lisbon, 1099-023, Portugal
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Lisbon, 1769-001, Portugal
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Porto, 4100-180, Portugal
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Porto, 4200-319, Portugal
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Vila Nova de Gaia, 4434-502, Portugal
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Cluj-Napoca, 400015, Romania
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Cluj-Napoca, 400058, Romania
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Kazan', 420012, Russia
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Moscow, 105229, Russia
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Moscow, 115478, Russia
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Saint Petersburg, 194291, Russia
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Saint Petersburg, 197342, Russia
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Saint Petersburg, 197758, Russia
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Volgograd, 400138, Russia
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Barcelona, 08003, Spain
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Madrid, 08035, Spain
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Madrid, 28034, Spain
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Madrid, 28041, Spain
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Málaga, 29010, Spain
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Seville, 41013, Spain
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Vigo(Pontevedra), 36204, Spain
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Zaragoza, 50009, Spain
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Linköping, 581 85, Sweden
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Örebro, 701 85, Sweden
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Uppsala, SE-751 85, Sweden
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Ankara, 06230, Turkey (Türkiye)
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Ankara, 06280, Turkey (Türkiye)
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Istanbul, 34662, Turkey (Türkiye)
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Istanbul, 34844, Turkey (Türkiye)
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Izmir, 35100, Turkey (Türkiye)
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Izmir, 35110, Turkey (Türkiye)
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Manisa, 45030, Turkey (Türkiye)
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Chernivtsі, 58013, Ukraine
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Dnipro, 49102, Ukraine
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Kharkiv Region, 61070, Ukraine
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Kryvyi Rih, 50048, Ukraine
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Kyiv, 03115, Ukraine
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Sumy, 40022, Ukraine
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Uzhhorod, 88000, Ukraine
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Zaporizhzhia, 69040, Ukraine
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Aberdeen, AB2 2ZB, United Kingdom
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London, SW3 6JJ, United Kingdom
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Manchester, M20 4BX, United Kingdom
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Nottingham, NG5 1PB, United Kingdom
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Sutton, SM2 5PT, United Kingdom
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Wolverhampton, WV10 0QP, United Kingdom