Targeted pill tested for Hard-to-Treat cancers driven by RET gene

NCT ID NCT03157128

Ongoing Disease control Sponsor: Eli Lilly and Company Source: ClinicalTrials.gov ↗

Summary

This study is testing an oral medication called selpercatinib (LOXO-292) for people with advanced solid tumors that have a specific genetic change in the RET gene. The goal is to find a safe dose and see if the drug can shrink these difficult-to-treat cancers. It is for patients whose cancer has continued to grow despite standard treatments or for whom no standard therapy exists.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

Get updates

Get notified about this study

Our safety recommendation!

By submitting, you agree to our Terms of use

Contacts and locations

Show contact details

Locations

APHM Hôpital de la Timone

Marseille, 13385, France
Asan Medical Center

Seoul, Seoul-teukbyeolsi [Seoul], 05505, South Korea
BC Cancer Vancouver

Vancouver, British Columbia, V5Z 4E6, Canada
Centre Leon Berard

Lyon, Auvergne-Rhône-Alpes, 69008, France
City of Hope National Medical Center

Duarte, California, 91010-0269, United States
Cleveland Clinic Foundation

Cleveland, Ohio, 44195, United States
Comprehensive Cancer Centers of Nevada

Las Vegas, Nevada, 89169, United States
Dana-Farber Cancer Institute

Boston, Massachusetts, 02215, United States
Emory University

Atlanta, Georgia, 30329-5102, United States
Gustave Roussy

Villejuif, 94805, France
Hadassah Medical Center

Jerusalem, 9112001, Israel
Hoag Memorial Hospital Presbyterian

Newport Beach, California, 92663, United States
Hokkaido University Hospital

Sapporo, Hokkaido, 060-8648, Japan
Hospital Madrid Norte Sanchinarro

Madrid, 28050, Spain
Hospital Universitari Vall d'Hebron

Barcelona, Barcelona [Barcelona], 8035, Spain
Hospital Universitario Fundación Jiménez Díaz

Madrid, 28040, Spain
Huntsman Cancer Institute

Salt Lake City, Utah, 84112, United States
Hyogo Cancer Center

Akashi, Hyōgo, 673-8558, Japan
Hôpital Européen Georges Pompidou

Paris, Île-de-France Region, 75015, France
Institut Bergonié - Centre Régional de Lutte Contre Le Cancer de Bordeaux et Sud Ouest

Bordeaux, Aquitaine, 33076, France
Institut du Cancer de Montpellier - Val d'aurelle

Montpellier, 34298, France
Irvine Medical Center

Orange, California, 92868, United States
Istituto Nazionale dei Tumori

Milan, Lombardy, 20133, Italy
Japanese Foundation for Cancer Research

Koto, Tokyo, 135-8550, Japan
Johns Hopkins University

Baltimore, Maryland, 21287, United States
Kaiser Permanente

Oakland, California, 94611-5400, United States
Kaiser Permanente Medical Center

Walnut Creek, California, 94596, United States
Kanazawa University Hospital

Kanazawa, Ishikawa-ken, 920-8641, Japan
Kantonsspital Luzern

Lucerne, Canton of Lucerne, 6000, Switzerland
Kindai University Hospital

Osaka Sayama-shi, Osaka, 589 8511, Japan
Massachusetts General Hospital

Boston, Massachusetts, 02114, United States
Mayo Clinic

Rochester, Minnesota, 55905-0002, United States
Mayo Clinic in Florida

Jacksonville, Florida, 32224, United States
Mayo Clinic of Scottsdale

Scottsdale, Arizona, 85259, United States
Memorial Hospital Pembroke

Pembroke, Florida, 33028, United States
Memorial Sloan Kettering Cancer Center

New York, New York, 10065, United States
NYU Langone

New York, New York, 10016, United States
Nagoya University Hospital

Nagoya, Aichi-ken, 466-8560, Japan
National Cancer Center

Goyang-si, Kyǒnggi-do, 10408, South Korea
National Cancer Center Hospital

Chuo-ku, Tokyo, 104-0045, Japan
National Cancer Center Hospital East

Kashiwa, Chiba, 277-8577, Japan
National Cancer Centre Singapore

Singapore, Central Singapore, 169610, Singapore
National Hospital Organization Kyushu Cancer Center

Fukuoka, 811-1395, Japan
National Taiwan University Hospital

Taipei, 10002, Taiwan
Ochsner Clinic Foundation

New Orleans, Louisiana, 70121, United States
Ohio State University Hospital

Columbus, Ohio, 43210-1257, United States
Okayama University Hospital

Okayama, 700-8558, Japan
Oregon Health and Science University

Portland, Oregon, 97201, United States
Osaka City General Hospital

Osaka, 534-0021, Japan
Peter MacCallum Cancer Centre

Melbourne, Victoria, 3000, Australia
Prince of Wales Hospital

Hong Kong, Shatin, New Territories, 999077, Hong Kong
Rigshospitalet

Copenhagen, 2200, Denmark
Roswell Park Cancer Institute

Buffalo, New York, 14263, United States
Royal Marsden Hospital

London, SW3 6JJ, United Kingdom
Royal North Shore Hospital

St Leonards, New South Wales, 2065, Australia
START Midwest

Grand Rapids, Michigan, 49546, United States
Samsung Medical Center

Seoul, 06351, South Korea
Sarah Cannon Research Institute SCRI

Nashville, Tennessee, 37203, United States
Sarah Cannon Research Institute at HealthOne

Denver, Colorado, 80218, United States
Seoul National University Bundang Hospital

Seongnam, Kyǒnggi-do, 13620, South Korea
Severance Hospital, Yonsei University Health System

Seoul, Seoul-teukbyeolsi [Seoul], 03722, South Korea
Shaare Zedek Medical Center

Jerusalem, Jerusalem, 9103102, Israel
Sheba Medical Center

Ramat Gan, Central District, 5262100, Israel
Soroka Medical Center - Pediatric Outpatient Clinic

Beersheba, 8410101, Israel
Taichung Veterans General Hospital

Taichung, 40705, Taiwan
Thomas Jefferson University

Philadelphia, Pennsylvania, 19107, United States
Tominaga Hospital

Nagaizumi-cho,Sunto-gun, Shizuoka, 411-8777, Japan
Tottori University Hospital

Yonago, Tottori, 683-8504, Japan
UCLA Medical Center

Los Angeles, California, 90095, United States
UCSF Medical Center at Mission Bay

San Francisco, California, 94158, United States
USO-Virginia Cancer Specialists, PC

Fairfax, Virginia, 22031, United States
University of California - San Diego

San Diego, California, 92103, United States
University of Chicago Medicine-Comprehensive Cancer Center

Chicago, Illinois, 60637, United States
University of Maryland Medical Center

Baltimore, Maryland, 21201, United States
University of Michigan

Ann Arbor, Michigan, 48109, United States
University of North Carolina

Chapel Hill, North Carolina, 27514, United States
University of Pennsylvania Hospital

Philadelphia, Pennsylvania, 19104, United States
University of Texas MD Anderson Cancer Center

Houston, Texas, 77030, United States
University of Texas Southwestern Medical Center at Dallas

Dallas, Texas, 75390-9063, United States
University of Wisconsin-Madison Hospital and Health Clinic

Madison, Wisconsin, 53792, United States
Universitätsklinikum Köln

Cologne, North Rhine-Westphalia, 50931, Germany
Universitätsklinikum Würzburg A. ö. R.

Würzburg, Bavaria, 97080, Germany
Vanderbilt University Medical Center

Nashville, Tennessee, 37232-6303, United States
Washington University Medical School

St Louis, Missouri, 63110, United States
Yale Cancer Center

New Haven, Connecticut, 06520, United States

Conditions

Explore the condition pages connected to this study.

ANY SOLID TUMOR COLON CANCER MEDULLARY THYROID CANCER NON SMALL CELL LUNG CANCER