New pill tested as last hope for Tough-to-Treat blood cancer

NCT ID NCT02227251

Recruiting now Disease control Sponsor: Karyopharm Therapeutics Inc Source: ClinicalTrials.gov ↗

Summary

This study is testing an oral medication called selinexor for adults with an aggressive type of blood cancer (diffuse large B-cell lymphoma) that has come back or stopped responding to at least two prior treatments. The main goal is to see if the drug can shrink the cancer and for how long. Researchers are also comparing two different doses to find the best balance of effectiveness and side effects.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

Get updates

Get notified about this study

Our safety recommendation!

By submitting, you agree to our Terms of use

Contacts and locations

Show contact details

Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

AOU Maggiore della Carità SCDU Ematologia
RECRUITING

Florence, Italy

Contact Phone: •••-•••-•••• Email: •••••@•••••

Contact
AZ Delta
COMPLETED

Roeselare, Belgium
AZ Sint-Jan
COMPLETED

Bruges, 8000, Belgium
Addenbrooke's Hospital Cambridge
COMPLETED

Cambridge, CB2 0QQ, United Kingdom
Akh Linz Innere Med III - Zentrum für Hämatologie und med. Onkologie
COMPLETED

Linz, Austria
Ashford Cancer Centre
COMPLETED

Kurralta Park, South Australia, 5037, Australia
Assuta Medical Center
COMPLETED

Tel Aviv, 69710, Israel
Azienda Ospedaliero-Universitaria Senese
RECRUITING

Siena, Italy

Contact Phone: •••-•••-•••• Email: •••••@•••••

Contact
Boca Raton Cancer Research Medical Center
COMPLETED

Plantation, Florida, United States
CH Jolimont
COMPLETED

La Louvière, 7100, Belgium
CHRU de Lille - Hopital Claude-Huriez
COMPLETED

Lille, France
CHU Lyon Sud
COMPLETED

Pierre-Bénite, Lyon, France
CHU Montpellier
COMPLETED

Montpellier, France
CSolnoky ferenc Hospital
COMPLETED

Veszprém, Hungary
Calvary Mater Newcastle Hospital
COMPLETED

Waratah, New South Wales, 2298, Australia
Cancer Institute (WIA)
COMPLETED

Chennai, Tamil Nadu, 600020, India
Centre Henri Becquerel
SUSPENDED

Rouen, France
Centre Hospitalier Universitaire Henri Mondor
COMPLETED

Créteil, France
Centrum Onkologii- Insytut Im. Marii Skłodowskiej-Curie Klinika Nowotworow Ukladu Chlonnego
COMPLETED

Warsaw, 02-781, Poland
Charite Universitatsmedizin Berlin (Benjamin Franklin Campus)
COMPLETED

Berlin, Germany
Charite Universitatsmedizin Berlin (Virchow Campus)
COMPLETED

Berlin, Germany
Christchurch Hospital
COMPLETED

Christchurch, 8001, New Zealand
Chu Dijon-Bourgogne - Hematologie Clinique
COMPLETED

Dijon, France
Città della Salute e della Scienza di Torino
COMPLETED

Torino, Italy
Cleveland Clinic Foundation
COMPLETED

Cleveland, Ohio, 44195, United States
Clinical Research Alliance
COMPLETED

Lake Success, New York, United States
Cliniques Universitaires Saint-Luc
COMPLETED

Brussels, Belgium
Clínica Universidad De Navarra
COMPLETED

Pamplona, Spain
Dana Farber Cancer Institute
COMPLETED

Boston, Massachusetts, United States
Dayanand Medical College and Hospital
COMPLETED

Ludhiana, Punjab, 160012, India
Deenanath Mangeshkar Hospital
COMPLETED

Pune, Maharashtra, 411004, India
Department of clinical hematology ,university hospital Ioannina
RECRUITING

Ioannina, 45110, Greece

Contact Phone: •••-•••-•••• Email: •••••@•••••

Contact
Derriford Hospital
COMPLETED

Plymouth, PL6 8DH, United Kingdom
Dr. B.R.A. Institute Rotary Cancer Hospital All India Institute of Medical Sciences
COMPLETED

New Delhi, 110029, India
Epworth Hospital
COMPLETED

East Melbourne, Victoria, 3001, Australia
Ev. Diakonie-Krankenhaus gGmbH
COMPLETED

Bremen, 28239, Germany
Fiona Stanley Hospital
COMPLETED

Murdoch, Western Australia, 6150, Australia
Fondazione Policlinico Universitario A. Gemelli
RECRUITING

Rome, Italy

Contact Phone: •••-•••-•••• Email: •••••@•••••

Contact
G. Kuppu Swamy Naidu Hospital
COMPLETED

Coimbatore, Tamil Nadu, 641037, India
Gabrail Cancer Center
COMPLETED

Canton, Ohio, 44718, United States
Gemeinschaftspraxis Haematologie and Onkologie-Dresden
COMPLETED

Dresden, 01307, Germany
Gloucestershire Royal Hospital
COMPLETED

Gloucester, Gloucestershire, GL1 3NN, United Kingdom
Greenville Hospital System
COMPLETED

Greenville, South Carolina, 29605, United States
Guy's and St Thomas' NHS Foundation Trust
COMPLETED

London, United Kingdom
H-Hartziekenhuis Roeselare-Menen
COMPLETED

Roeselare, Belgium
HELIOS Klinikum Bad Saarow
COMPLETED

Bad Saarow, Germany
Hadassah Medical Center
COMPLETED

Jerusalem, Israel
Haematology Department and HCT Unit G.Papanicolaou Hospital
RECRUITING

Exochi, Thessaloniki, Greece

Contact Phone: •••-•••-•••• Email: •••••@•••••

Contact
Hematology Clinic,General Hospital of Athens,G. Gennimatos
RECRUITING

Athens, 11527, Greece

Contact

Contact Phone: •••-•••-•••• Email: •••••@•••••
Hematology Department Laiko General Hospital
RECRUITING

Athens, Greece

Contact Phone: •••-•••-•••• Email: •••••@•••••

Contact
Hematology Department St John's Cancer Centre
COMPLETED

Lublin, Poland
Hematology-Oncology & Stem Cell Transplantation Unit, National Cancer Institute, Fondazione 'G. Pascale', IRCCS
RECRUITING

Naples, 80131, Italy

Contact Phone: •••-•••-•••• Email: •••••@•••••

Contact
Hematology-Soroka
COMPLETED

Beersheba, Israel
Hospital Clinic i Provincial de Barcelona
COMPLETED

Barcelona, Spain
Hospital Universitario La Paz
COMPLETED

Madrid, Spain
Hospital Universitario Virgen del Rocio
COMPLETED

Seville, Spain
Hospital Universitario de Salamanca
COMPLETED

Salamanca, 37007, Spain
Hospital University Vall d'Hebron
COMPLETED

Barcelona, 08035, Spain
Hospital de Son Llàtzer
COMPLETED

Palma de Mallorca, Spain
Hospitalier de la Rochelle-Ré-Aunis
COMPLETED

La Rochelle, France
Hospitla Universitari Germans Trias i Pujol - ICO
COMPLETED

Badalona, 8916, Spain
Hostpial Saint Louis - CIRCO (Centre d'Investigations et de Recherche Clinique en Oncologie)
COMPLETED

Paris, 75010, France
Hôpital Necker Service d'Hématologie Adult
COMPLETED

Paris, France
IRCH, All India Institute of Medical Sciences
COMPLETED

Delhi, India, 110029, India
Icon Cancer Care
COMPLETED

South Brisbane, Queensland, 4101, Australia
Institut Jules Bordet
COMPLETED

Brussels, 1000, Belgium
Institut za onkologiju Vojvodine
COMPLETED

Kamenitz, 21204, Serbia
Institut za onkologiju i radiologiju Srbije
COMPLETED

Belgrade, 11000, Serbia
Institute of Medical Sciences & SUM Hospital
COMPLETED

Bhubaneswar, Odisha, 751003, India
Instituto di Ematologia Seragnoli Pad 8 Universita di Bologna
COMPLETED

Bologna, Italy
Instytut Hematologii i Transfuzjologii
COMPLETED

Warsaw, 02-776, Poland
Jaslok Hospital and Research Centre
COMPLETED

Mumbai, Maharashtra, 400026, India
John Theurer Cancer Center at Hackensack University Medical Center
COMPLETED

Hackensack, New Jersey, United States
King George's Medical University (KGMU)
COMPLETED

Lucknow, Uttar Pradesh, 226003, India
King's College Hospital
COMPLETED

London, SE5 9RS, United Kingdom
Klinicko Bolnick Centar Zemun Odeljenje hematologije
COMPLETED

Belgrade, 11000, Serbia
Klinikum Kempten Klinik für Innere Medizin III - Hämatologie, Onkologie und Palliativmedizin
COMPLETED

Cologne, Germany
Klinikum Leverkusen
COMPLETED

Leverkusen, Germany
Klinikum Ludwigshafen
COMPLETED

Ludwigshafen, Germany
Klinikum Nürnberg Nord
COMPLETED

Nuremberg, 90419, Germany
Klinički centar Niš Klinika za hematologiju
COMPLETED

Niš, 18000, Serbia
Klinički centar Srbije Klinika za hematologiju
COMPLETED

Belgrade, 11000, Serbia
Kliničko bolnički centar Zvezdara
COMPLETED

Belgrade, 11000, Serbia
Krankenhaus Barmherzigen Schwestern Linz
COMPLETED

Linz, Austria
Krankenhaus der Elisabethinen Linz GmbH
COMPLETED

Linz, Austria
LKH Leoben Department for Haemato-Oncology
COMPLETED

Leoben, 8700, Austria
LUMC (leidse universitair medisch centrum)
COMPLETED

Leiden, Netherlands
Lahey Clinic
COMPLETED

Burlington, Massachusetts, United States
Leeds Teaching Hospitals NHS Trust
COMPLETED

Leeds, Yorkshire, United Kingdom
Liverpool Hospital, Ingham Institute of Medical Research
COMPLETED

Liverpool, New South Wales, 2170, Australia
MCM (Małopolskie Centrum Medyczne)
COMPLETED

Krakow, 30-510, Poland
MD Anderson
COMPLETED

Houston, Texas, 77030, United States
Maria Sklodowska Curie National Research Institute
RECRUITING

Warsaw, Poland

Contact Phone: •••-•••-•••• Email: •••••@•••••

Contact
Marseille Institute of Cancer - Institut J. Paoli and I. Calmettes
COMPLETED

Marseille, France
Martin-Luther-University Halle-Wittenberg Department of Oncology
COMPLETED

Halle, Germany
Medical University of Graz
COMPLETED

Graz, 8036, Austria
Medical University of Vienna (MUW) Department of Medicine I
COMPLETED

Vienna, Austria
Medizinische Hochschule
COMPLETED

Hanover, Germany
Medizinische Universität Innsbruck für Innere Medizin
COMPLETED

Innsbruck, Austria
Meenakshi Mission Hospital & Research Centre
COMPLETED

Madurai, Tamil Nadu, 625107, India
Memorial Provincial Specialist Hospital in Lodz
COMPLETED

Lodz, 62-1010, Poland
Monash Medical Centre
COMPLETED

Clayton, Victoria, 3168, Australia
National & Kapodistrian University of Athens, Attiko University Hospital
COMPLETED

Chaïdári, 12462, Greece
National & Kapodistrian University of Athens, Laiko General Hospital
COMPLETED

Athens, 11527, Greece
Netaji Subhas Chandra Bose Cancer Research Hospital
COMPLETED

Kolkata, West Bengal, 700094, India
Netaji Subhas Chandra Bose Cancer Research Institute
COMPLETED

Kolkata, West Bengal, 70016, India
New York Presbyterian Hospital/ Cornell Medical College
COMPLETED

New York, New York, 10065, United States
Nil Ratan Sircar Medical College and Hospital
COMPLETED

Kolkata, West Bengal, 700014, India
North Shore Hospital
COMPLETED

Auckland, 0622, New Zealand
Northwick Park Hospital
COMPLETED

Harrow, Middlesex, HA1 3UJ, United Kingdom
Norton Cancer Institute
COMPLETED

Louisville, Kentucky, 40241, United States
Országos Onkológiai Intézet "A" Belgyógyászati Onkológiai Osztály
COMPLETED

Budapest, 1122, Hungary
Oxford University Hospitals NHS Trust Oxford Cancer and Haematology Centre, Churchill Hospital
COMPLETED

Oxford, OX3 7LE, United Kingdom
Pitié-Salpêtrière Hospital
SUSPENDED

Paris, France
Prince Aly Khan Hospital
COMPLETED

Mumbai, Maharashtra, 400010, India
Princess Margaret Cancer Centre
COMPLETED

Toronto, Ontario, Canada
Princess Royal University Hospital (PRUH)
COMPLETED

London, SE5 9RS, United Kingdom
Pécsi Tudományegyetem, ÁOK, I. számú Belgyógyászati Klinika
COMPLETED

Pécs, Hungary
Rabin Medical Center
COMPLETED

Petah Tikva, 49100, Israel
Rajiv Gandhi Cancer Hospital
COMPLETED

New Delhi, National Capital Territory of Delhi, 110085, India
Rambam Healthcare Campus
COMPLETED

Haifa, Israel
Regional Cancer Centre
COMPLETED

Thiruvananthapuram, Kerala, 695011, India
Regional Cancer Centre, IGIMS
COMPLETED

Patna, Bihar, 800014, India
Robert H. Lurie Comprehensive Cancer Center/Northwestern University
COMPLETED

Chicago, Illinois, United States
Rotkreuzklinikum München
COMPLETED

München, Germany
Royal Adelaide Hospital
COMPLETED

Adelaide, South Australia, 5000, Australia
Royal Liverpool University Hospital
COMPLETED

Liverpool, United Kingdom
Royal Marsden Hospital
COMPLETED

Sutton, London, SM2 5PT, United Kingdom
SCDU Ematologia, Division of Hematology, Dept. of Translational Medicine, Universita del Piemonte Orientale
COMPLETED

Novara, 28100, Italy
SODc Ematologica ,AOU Careggi
RECRUITING

Florence, 50134, Italy

Contact Phone: •••-•••-•••• Email: •••••@•••••

Contact
SRM Institutes for Medical Science
COMPLETED

Vadapalani, Chennai, 600026, India
Samodzielny Publiczny Szpital Kliniczny nr 1 w Lublinie
WITHDRAWN

Lublin, 20-081, Poland
Samodzielny Publiczny Zakład Opieki Zdrowotnej Ministerstwa
COMPLETED

Olsztyn, 10-228, Poland
Saveetha Medical College Hospital
COMPLETED

Chennai, Tamil Nadu, 602105, India
Second Depth of Internal Medicine, Attiko University Hospital
RECRUITING

Athens, Greece

Contact Phone: •••-•••-•••• Email: •••••@•••••

Contact
Semmelweis Egyetem Általános Orvosi Kar
COMPLETED

Budapest, 1083, Hungary
Semmelweis University Department of Medicine and Oncology
COMPLETED

Budapest, Hungary
Sheba Medical Center
COMPLETED

Tel Litwinsky, Israel
Sir Mortimer B Davis Jewish General Hospital/McGill University
COMPLETED

Montreal, Quebec, Canada
Somogy Megyei Kaposi Mór Oktató Kórház
COMPLETED

Kaposvár, 7400, Hungary
Southampton University Hospital
COMPLETED

Southampton, Hampshire, SO16 6YD, United Kingdom
Specialized Hospital for Active Treatment of Haematological Diseases EAD
COMPLETED

Sofia, 1756, Bulgaria
St. Vincent's Hospital Sydney
COMPLETED

Darlinghurst, New South Wales, 2010, Australia
St. Vincent's Melbourne
COMPLETED

Fitzroy, Victoria, 3065, Australia
Stony Brook University Hospital
COMPLETED

Stony Brook, New York, 11794, United States
Swedish Cancer Institute
COMPLETED

Seattle, Washington, 98104, United States
Szpitale Wojewódzkie w Gdyni, Gdyńskie Centrum onkologii
COMPLETED

Gdynia, 81-519, Poland
TATA Memorial Centre
COMPLETED

Kolkata, West Bengal, 700156, India
TLV Sorasky Medical Center
COMPLETED

Tel Aviv, Israel
The Alfred Hospital
COMPLETED

Melbourne, Victoria, 3004, Australia
The Christie NHS Foundation Trust
COMPLETED

Manchester, M20 4BX, United Kingdom
The Clatterbridge Cancer Centre NHS Foundation Trust
COMPLETED

Liverpool, United Kingdom
Tufts Medical Center
COMPLETED

Boston, Massachusetts, United States
UACC Arizona
COMPLETED

Tucson, Arizona, 85704, United States
UZ Gent
COMPLETED

Ghent, 9000, Belgium
Uni. Klinik für Innere Medizin III Universitätsklinikum der PMU LKH Salzburg
COMPLETED

Salzburg, A-5020, Austria
Uniklinik Aachen Klinik für Hämatologie, Onkologie, Hämostaseologie und Stammzelltransplantation
COMPLETED

Aachen, Germany
Unite Hemopathies Lymphoides Chu Henri Mondor
COMPLETED

Créteil, France
Univ. General Hospital Hietzing
COMPLETED

Vienna, Austria
University Hospital for Active Treatment Dr. Georgi Stranski
COMPLETED

Pleven, 5800, Bulgaria
University Hospitals Seidman Cancer Center
COMPLETED

Cleveland, Ohio, United States
University Multiprofile Hospital for Active Treatment Sveti Ivan Rilski EAD
COMPLETED

Sofia, 1431, Bulgaria
University of California Los Angeles (UCLA)
COMPLETED

Santa Monica, California, 90404, United States
University of California San Francisco
COMPLETED

San Francisco, California, United States
University of Chicago
COMPLETED

Chicago, Illinois, 60637, United States
University of Massachusetts Medical School
COMPLETED

Worcester, Massachusetts, United States
University of Oklahoma
COMPLETED

Oklahoma City, Oklahoma, United States
University of Patras Medical School
COMPLETED

Pátrai, 26504, Greece
Universität Heidelberg Medizinische Klinik V Hämatologie, Onkologie und Rheumatologie
COMPLETED

Heidelberg, Germany
Uniwersytecki Szpital Kliniczny im. Jana Mikulicza
RECRUITING

Wroclaw, Radeckiego, 50-367, Poland

Contact Phone: •••-•••-•••• Email: •••••@•••••

Contact
VUMc (Vrije Universiteit Amsterdam)
COMPLETED

Amsterdam, 1081 HV, Netherlands
Veszprém Megyei Csolnoky Ferenc Kórház
COMPLETED

Veszprém, 8200, Hungary
Virginia Mason Hospital & Medical Center
COMPLETED

Seattle, Washington, United States
Wojewodzki Szpital Specjalistyczny w Legnicy
RECRUITING

Legnica, 59-220, Poland

Contact Phone: •••-•••-•••• Email: •••••@•••••

Contact
Wolfson MC
COMPLETED

Holon, Israel
Ziekenhuis Netwerk Antwerpen
COMPLETED

Antwerp, Belgium

Conditions

Explore the condition pages connected to this study.

DIFFUSE LARGE B CELL LYMPHOMA