New drug trial offers hope for Tough-to-Treat blood cancer patients

NCT ID NCT04562870

Summary

This study is testing an oral drug called selinexor for people with myelofibrosis, a serious bone marrow cancer, who have already tried and stopped responding to standard JAK inhibitor treatments. About 112 participants will be randomly assigned to receive either selinexor or their doctor's choice of other available treatments. The main goal is to see if selinexor can safely reduce spleen size and improve symptoms better than current options.

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Contacts and locations

Locations

  • Affiliated Hospital of Nantong University

    Nantong, Jiangsu, 226001, China

  • Asst Settelaghi, Ospedale Di Circolo E Fondazione Macchi

    Varese, 21100, Italy

  • Azienda Unita Sanitaria Locale Latina - Ospedale Santa Maria Goretti

    Latina, 4100, Italy

  • Centre Hospitalier Universitaire d'Angers (CHU Angers)

    Angers, 49933, France

  • Hospital Universitario 12 de Octubre

    Madrid, Madrid, 28041, Spain

  • Illinois Cancer Specialist

    Niles, Illinois, 60714, United States

  • Institut de Cancéro-Hématologie

    Brest, Brittany Region, 29609, France

  • Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS

    Meldola, Forlì-Cesena, 47014, Italy

  • Peking Union Medical College Hospital

    Beijing, Beijing Municipality, 100730, China

  • Pratia Onkologia Katowice

    Katowice, 40-519, Poland

  • Rocky Mountain Cancer Centers, LLP

    Aurora, Colorado, 80012, United States

  • Sir Run Run Shaw Hospital - Zhejiang University School of Medicine

    Hangzhou, Zhejiang, 310016, China

  • Suzhou University -The First Affiliated Hospital

    Suzhou, Jiangsu, 215007, China

  • Texas Oncology - Northeast Texas

    Tyler, Texas, 75702, United States

  • The First Hospital of Jilin University

    Changchun, Jilin, 130021, China

  • The Oncology Institute of Hope and Innovation

    Pasadena, California, 91105, United States

  • The Second Affiliated Hospital of Soochow University

    Suzhou, Jiangsu, 215004, China

  • Union Hospital, Tongji Medical College, Huazhong University of Science and Technology

    Wuhan, Hubei, 430022, China

  • University General Hospital "ATTIKON"

    Athens, Attica, 12462, Greece

  • University of Perugia Department of Medicine Hematology Section

    Perugia, 6132, Italy

  • Università degli Studi di Firenze - Azienda Ospedaliero - Universitaria Careggi - Dipartimento di medicina sperimentale e clinica

    Florence, 50134, Italy

Conditions

Explore the condition pages connected to this study.