New hope for kids with devastating brain cancers: testing a novel drug combo

NCT ID NCT05099003

Summary

This study is testing whether adding a new oral drug called selinexor to standard radiation therapy is safe and effective for children and young adults with newly diagnosed, aggressive brain tumors (DIPG or high-grade glioma). The first part of the trial aims to find the safest dose of selinexor. The second part will see if this combination helps control the cancer and extend survival compared to past treatments.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • Albany Medical Center

    RECRUITING

    Albany, New York, 12208, United States

    Contact

    Contact Phone: •••-•••-••••

  • Alfred I duPont Hospital for Children

    RECRUITING

    Wilmington, Delaware, 19803, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Arkansas Children's Hospital

    RECRUITING

    Little Rock, Arkansas, 72202-3591, United States

    Contact

    Contact Phone: •••-•••-••••

  • Arnold Palmer Hospital for Children

    RECRUITING

    Orlando, Florida, 32806, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • BI-LO Charities Children's Cancer Center

    RECRUITING

    Greenville, South Carolina, 29605, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Banner Children's at Desert

    RECRUITING

    Mesa, Arizona, 85202, United States

    Contact

    Contact Phone: •••-•••-••••

  • Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center

    RECRUITING

    Houston, Texas, 77030, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Blank Children's Hospital

    RECRUITING

    Des Moines, Iowa, 50309, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • British Columbia Children's Hospital

    SUSPENDED

    Vancouver, British Columbia, V6H 3V4, Canada

  • C S Mott Children's Hospital

    RECRUITING

    Ann Arbor, Michigan, 48109, United States

    Contact

    Contact Phone: •••-•••-••••

  • CHU de Quebec-Centre Hospitalier de l'Universite Laval (CHUL)

    RECRUITING

    Québec, G1V 4G2, Canada

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • CancerCare Manitoba

    RECRUITING

    Winnipeg, Manitoba, R3E 0V9, Canada

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Cardinal Glennon Children's Medical Center

    RECRUITING

    St Louis, Missouri, 63104, United States

    Contact Phone: •••-•••-••••

    Contact

  • Cedars Sinai Medical Center

    RECRUITING

    Los Angeles, California, 90048, United States

    Contact

    Contact Phone: •••-•••-••••

  • Centre Hospitalier Universitaire Sainte-Justine

    RECRUITING

    Montreal, Quebec, H3T 1C5, Canada

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Centre Hospitalier Universitaire de Sherbrooke-Fleurimont

    RECRUITING

    Sherbrooke, Quebec, J1H 5N4, Canada

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Children's Healthcare of Atlanta - Arthur M Blank Hospital

    RECRUITING

    Atlanta, Georgia, 30329, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Children's Hospital Colorado

    RECRUITING

    Aurora, Colorado, 80045, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Children's Hospital Los Angeles

    RECRUITING

    Los Angeles, California, 90027, United States

    Contact Phone: •••-•••-••••

    Contact

  • Children's Hospital Medical Center of Akron

    RECRUITING

    Akron, Ohio, 44308, United States

    Contact

    Contact Phone: •••-•••-••••

  • Children's Hospital New Orleans

    RECRUITING

    New Orleans, Louisiana, 70118, United States

    Contact

    Contact Phone: •••-•••-••••

  • Children's Hospital and Medical Center of Omaha

    RECRUITING

    Omaha, Nebraska, 68114, United States

    Contact

    Contact Phone: •••-•••-••••

  • Children's Hospital of Alabama

    RECRUITING

    Birmingham, Alabama, 35233, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Children's Hospital of Michigan

    RECRUITING

    Detroit, Michigan, 48201, United States

    Contact

    Contact Email: •••••@•••••

  • Children's Hospital of Orange County

    RECRUITING

    Orange, California, 92868, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Children's Hospital of Philadelphia

    RECRUITING

    Philadelphia, Pennsylvania, 19104, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Children's Hospital of Pittsburgh of UPMC

    RECRUITING

    Pittsburgh, Pennsylvania, 15224, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Children's Hospital of San Antonio

    RECRUITING

    San Antonio, Texas, 78207, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Children's Hospital of The King's Daughters

    RECRUITING

    Norfolk, Virginia, 23507, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Children's Hospital of Wisconsin

    RECRUITING

    Milwaukee, Wisconsin, 53226, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Children's Hospitals and Clinics of Minnesota - Minneapolis

    RECRUITING

    Minneapolis, Minnesota, 55404, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Children's Mercy Hospitals and Clinics

    RECRUITING

    Kansas City, Missouri, 64108, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Children's National Medical Center

    RECRUITING

    Washington D.C., District of Columbia, 20010, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Christchurch Hospital

    RECRUITING

    Christchurch, 8011, New Zealand

    Contact

    Contact Phone: •••-•••-••••

  • Cincinnati Children's Hospital Medical Center

    RECRUITING

    Cincinnati, Ohio, 45229, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Connecticut Children's Medical Center

    RECRUITING

    Hartford, Connecticut, 06106, United States

    Contact

    Contact Phone: •••-•••-••••

  • Cook Children's Medical Center

    RECRUITING

    Fort Worth, Texas, 76104, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital

    RECRUITING

    Grand Rapids, Michigan, 49503, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Dana-Farber Cancer Institute

    RECRUITING

    Boston, Massachusetts, 02215, United States

    Contact

    Contact Phone: •••-•••-••••

  • Dayton Children's Hospital

    RECRUITING

    Dayton, Ohio, 45404, United States

    Contact

    Contact Phone: •••-•••-••••

  • Dell Children's Medical Center of Central Texas

    RECRUITING

    Austin, Texas, 78723, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Driscoll Children's Hospital

    RECRUITING

    Corpus Christi, Texas, 78411, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • East Carolina University

    RECRUITING

    Greenville, North Carolina, 27834, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • East Tennessee Childrens Hospital

    RECRUITING

    Knoxville, Tennessee, 37916, United States

    Contact Phone: •••-•••-••••

    Contact

  • Eastern Maine Medical Center

    RECRUITING

    Bangor, Maine, 04401, United States

    Contact

    Contact Phone: •••-•••-••••

  • El Paso Children's Hospital

    RECRUITING

    El Paso, Texas, 79905, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Geisinger Medical Center

    RECRUITING

    Danville, Pennsylvania, 17822, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Golisano Children's Hospital of Southwest Florida

    RECRUITING

    Fort Myers, Florida, 33908, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Hackensack University Medical Center

    RECRUITING

    Hackensack, New Jersey, 07601, United States

    Contact

    Contact Phone: •••-•••-••••

  • Hospital for Sick Children

    SUSPENDED

    Toronto, Ontario, M5G 1X8, Canada

  • IWK Health Centre

    RECRUITING

    Halifax, Nova Scotia, B3K 6R8, Canada

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Jim Pattison Children's Hospital

    RECRUITING

    Saskatoon, Saskatchewan, S7N 0W8, Canada

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Johns Hopkins All Children's Hospital

    RECRUITING

    St. Petersburg, Florida, 33701, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Johns Hopkins University/Sidney Kimmel Cancer Center

    RECRUITING

    Baltimore, Maryland, 21287, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Kaiser Permanente-Oakland

    RECRUITING

    Oakland, California, 94611, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Kapiolani Medical Center for Women and Children

    RECRUITING

    Honolulu, Hawaii, 96826, United States

    Contact Phone: •••-•••-••••

    Contact

  • Laura and Isaac Perlmutter Cancer Center at NYU Langone

    RECRUITING

    New York, New York, 10016, United States

    Contact

    Contact Email: •••••@•••••

  • Legacy Emanuel Children's Hospital

    RECRUITING

    Portland, Oregon, 97227, United States

    Contact

    Contact Phone: •••-•••-••••

  • Loma Linda University Medical Center

    RECRUITING

    Loma Linda, California, 92354, United States

    Contact

    Contact Phone: •••-•••-••••

  • Lucile Packard Children's Hospital Stanford University

    RECRUITING

    Palo Alto, California, 94304, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • M D Anderson Cancer Center

    RECRUITING

    Houston, Texas, 77030, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Maine Children's Cancer Program

    RECRUITING

    Scarborough, Maine, 04074, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Mary Bridge Children's Hospital and Health Center

    RECRUITING

    Tacoma, Washington, 98405, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • McMaster Children's Hospital at Hamilton Health Sciences

    RECRUITING

    Hamilton, Ontario, L8N 3Z5, Canada

    Contact Phone: •••-•••-••••

    Contact

  • Medical City Dallas Hospital

    RECRUITING

    Dallas, Texas, 75230, United States

    Contact

    Contact Phone: •••-•••-••••

  • Memorial Sloan Kettering Cancer Center

    RECRUITING

    New York, New York, 10065, United States

    Contact

    Contact Phone: •••-•••-••••

  • Mercy Hospital Saint Louis

    RECRUITING

    St Louis, Missouri, 63141, United States

    Contact

    Contact Phone: •••-•••-••••

  • Miami Cancer Institute

    ACTIVE_NOT_RECRUITING

    Miami, Florida, 33176, United States

  • Miller Children's and Women's Hospital Long Beach

    RECRUITING

    Long Beach, California, 90806, United States

    Contact

    Contact Phone: •••-•••-••••

  • Montefiore Medical Center - Moses Campus

    SUSPENDED

    The Bronx, New York, 10467, United States

  • Morristown Medical Center

    RECRUITING

    Morristown, New Jersey, 07960, United States

    Contact

    Contact Phone: •••-•••-••••

  • NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center

    RECRUITING

    New York, New York, 10032, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Nationwide Children's Hospital

    RECRUITING

    Columbus, Ohio, 43205, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Nemours Children's Clinic-Jacksonville

    RECRUITING

    Jacksonville, Florida, 32207, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Nemours Children's Hospital

    RECRUITING

    Orlando, Florida, 32827, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Newark Beth Israel Medical Center

    RECRUITING

    Newark, New Jersey, 07112, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Norton Children's Hospital

    RECRUITING

    Louisville, Kentucky, 40202, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Novant Health Presbyterian Medical Center

    RECRUITING

    Charlotte, North Carolina, 28204, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Oregon Health and Science University

    RECRUITING

    Portland, Oregon, 97239, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Perth Children's Hospital

    RECRUITING

    Perth, Western Australia, 6009, Australia

    Contact

    Contact Email: •••••@•••••

  • Phoenix Childrens Hospital

    RECRUITING

    Phoenix, Arizona, 85016, United States

    Contact

    Contact Phone: •••-•••-••••

  • Primary Children's Hospital

    RECRUITING

    Salt Lake City, Utah, 84113, United States

    Contact

    Contact Phone: •••-•••-••••

  • Prisma Health Richland Hospital

    RECRUITING

    Columbia, South Carolina, 29203, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital

    RECRUITING

    Toledo, Ohio, 43606, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Providence Sacred Heart Medical Center and Children's Hospital

    RECRUITING

    Spokane, Washington, 99204, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Queensland Children's Hospital

    RECRUITING

    South Brisbane, Queensland, 4101, Australia

    Contact Phone: •••-•••-••••

    Contact

  • Rady Children's Hospital - San Diego

    RECRUITING

    San Diego, California, 92123, United States

    Contact Phone: •••-•••-••••

    Contact

  • Rainbow Babies and Childrens Hospital

    RECRUITING

    Cleveland, Ohio, 44106, United States

    Contact

    Contact Phone: •••-•••-••••

  • Rhode Island Hospital

    RECRUITING

    Providence, Rhode Island, 02903, United States

    Contact

    Contact Phone: •••-•••-••••

  • Riley Hospital for Children

    RECRUITING

    Indianapolis, Indiana, 46202, United States

    Contact

    Contact Phone: •••-•••-••••

  • Roswell Park Cancer Institute

    RECRUITING

    Buffalo, New York, 14263, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Royal Children's Hospital

    RECRUITING

    Parkville, Victoria, 3052, Australia

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital

    SUSPENDED

    New Brunswick, New Jersey, 08903, United States

  • Saint Christopher's Hospital for Children

    RECRUITING

    Philadelphia, Pennsylvania, 19134, United States

    Contact

    Contact Phone: •••-•••-••••

  • Saint Joseph's Hospital/Children's Hospital-Tampa

    RECRUITING

    Tampa, Florida, 33607, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Saint Joseph's Regional Medical Center

    RECRUITING

    Paterson, New Jersey, 07503, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Saint Jude Children's Research Hospital

    RECRUITING

    Memphis, Tennessee, 38105, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Saint Jude Midwest Affiliate

    RECRUITING

    Peoria, Illinois, 61637, United States

    Contact

    Contact Phone: •••-•••-••••

  • Saint Luke's Cancer Institute - Boise

    RECRUITING

    Boise, Idaho, 83712, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Sanford Broadway Medical Center

    RECRUITING

    Fargo, North Dakota, 58122, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Sanford USD Medical Center - Sioux Falls

    RECRUITING

    Sioux Falls, South Dakota, 57117-5134, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Seattle Children's Hospital

    RECRUITING

    Seattle, Washington, 98105, United States

    Contact

    Contact Phone: •••-•••-••••

  • Starship Children's Hospital

    RECRUITING

    Grafton, Auckland, 1145, New Zealand

    Contact

    Contact Phone: •••-•••-••••

  • State University of New York Upstate Medical University

    RECRUITING

    Syracuse, New York, 13210, United States

    Contact

    Contact Phone: •••-•••-••••

  • Sydney Children's Hospital

    RECRUITING

    Randwick, New South Wales, 2031, Australia

    Contact

    Contact Phone: •••-•••-••••

  • The Children's Hospital at TriStar Centennial

    RECRUITING

    Nashville, Tennessee, 37203, United States

    Contact

    Contact Phone: •••-•••-••••

  • The Children's Hospital at Westmead

    RECRUITING

    Westmead, New South Wales, 2145, Australia

    Contact

    Contact Phone: •••-•••-••••

  • The Montreal Children's Hospital of the MUHC

    RECRUITING

    Montreal, Quebec, H3H 1P3, Canada

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • The Steven and Alexandra Cohen Children's Medical Center of New York

    RECRUITING

    New Hyde Park, New York, 11040, United States

    Contact

    Contact Phone: •••-•••-••••

  • UCSF Benioff Children's Hospital Oakland

    RECRUITING

    Oakland, California, 94609, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • UCSF Medical Center-Mission Bay

    RECRUITING

    San Francisco, California, 94158, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • UT Southwestern/Simmons Cancer Center-Dallas

    RECRUITING

    Dallas, Texas, 75390, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • University of Alberta Hospital

    RECRUITING

    Edmonton, Alberta, T6G 2B7, Canada

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • University of Chicago Comprehensive Cancer Center

    RECRUITING

    Chicago, Illinois, 60637, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • University of Iowa/Holden Comprehensive Cancer Center

    RECRUITING

    Iowa City, Iowa, 52242, United States

    Contact

    Contact Phone: •••-•••-••••

  • University of Kentucky/Markey Cancer Center

    RECRUITING

    Lexington, Kentucky, 40536, United States

    Contact

    Contact Phone: •••-•••-••••

  • University of Miami Miller School of Medicine-Sylvester Cancer Center

    RECRUITING

    Miami, Florida, 33136, United States

    Contact

    Contact Phone: •••-•••-••••

  • University of Minnesota/Masonic Cancer Center

    RECRUITING

    Minneapolis, Minnesota, 55455, United States

    Contact

    Contact Phone: •••-•••-••••

  • University of Mississippi Medical Center

    SUSPENDED

    Jackson, Mississippi, 39216, United States

  • University of Nebraska Medical Center

    RECRUITING

    Omaha, Nebraska, 68198, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • University of Oklahoma Health Sciences Center

    RECRUITING

    Oklahoma City, Oklahoma, 73104, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • University of Texas Health Science Center at San Antonio

    RECRUITING

    San Antonio, Texas, 78229, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • University of Virginia Cancer Center

    RECRUITING

    Charlottesville, Virginia, 22908, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • University of Wisconsin Carbone Cancer Center - University Hospital

    RECRUITING

    Madison, Wisconsin, 53792, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Wake Forest University Health Sciences

    RECRUITING

    Winston-Salem, North Carolina, 27157, United States

    Contact

    Contact Phone: •••-•••-••••

  • Washington University School of Medicine

    RECRUITING

    St Louis, Missouri, 63110, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Yale University

    RECRUITING

    New Haven, Connecticut, 06520, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

Conditions

Explore the condition pages connected to this study.