New cocktail of four drugs shows promise for stubborn myeloma

NCT ID NCT03589222

Ongoing Disease control Sponsor: PETHEMA Foundation Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase 2 trial is testing a combination of four drugs—selinexor, bortezomib, dexamethasone, and daratumumab—in 62 patients with multiple myeloma that has returned or not responded to prior treatments. The goal is to see how many patients achieve a significant reduction in cancer. Participants may continue treatment indefinitely if it helps.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: selinexor, bortezomib, dexamethasone, daratumumab
What this could lead to: If successful, this combination could offer a new treatment option for patients with multiple myeloma that has stopped responding to other therapies.
What could go wrong: This is a small, early-phase trial (62 people) with no comparison group. Side effects from the drug combination may be significant, and results may not apply to all patients.

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Conditions

The condition(s) this trial relates to.

plasma cell myeloma refractory plasma cell neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

REFRACTORY MULTIPLE MYELOMA

Contacts and locations

Locations

Clinica Universitaria de Navarra

Pamplona, Spain
Hospital 12 de Octubre

Madrid, Spain
Hospital Central de Asturias

Oviedo, Spain
Hospital Clinic de Barcelona

Barcelona, Spain
Hospital Clinico Universitario de Salamanca

Salamanca, Spain
Hospital Clinico de Madrid

Madrid, Spain
Hospital Dr Peset

Valencia, Spain
Hospital Germans Trials i Pujol

Badalona, Spain
Hospital ICO de Girona

Girona, Spain
Hospital ICO de L'hospitalet

L'Hospitalet de Llobregat, Spain
Hospital Morales Meseguer

Murcia, Spain
Hospital Universitario de Canarias

Santa Cruz de Tenerife, Spain
Hospital Universitario de Donostia

San Sebastián, Spain
Hospital Universitario de Santiago

Santiago de Compostela, Spain
Hospital Virgen del Rocio

Seville, Spain

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