Experimental donor immune cells target Hard-to-Treat lymphoma
NCT ID NCT06285422
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This early-phase trial tests SC262, a therapy made from donor immune cells (CAR T cells) designed to attack a protein called CD22 on lymphoma cells. It is for people with non-Hodgkin's lymphoma that has come back or not responded to standard treatments. The main goal is to check safety, but researchers will also look for signs that the therapy shrinks tumors.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- SC262 (a type of immune cell therapy called CAR T cells, made from donor cells)
- What this could lead to
- If it works, this could offer a new treatment option for people with non-Hodgkin's lymphoma that has not responded to other therapies.
- What could go wrong
- This is a very early (Phase 1) and small study (6 participants). It primarily tests safety, not effectiveness. The therapy may not work or could cause serious side effects.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Fred Hutchinson Cancer Center
Seattle, Washington, 98109, United States
-
Swedish Cancer Institute
Seattle, Washington, 98104, United States
-
The University of Kansas Hospital
Kansas City, Kansas, 66160, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- A shot at safer CAR t: early brain protection for lymphoma patients?
- Can a Triple-Drug combo wipe out Slow-Growing lymphomas?
- Engineered immune cells take aim at Hard-to-Treat lymphomas
- Can donor immune cells be engineered to fight blood cancer?
- Can a simple blood test spot lymphoma earlier?
- What happens years after CAR-T therapy? a study aims to find out