Cheaper keytruda? new biosimilar SB27 tested in lung cancer

NCT ID NCT06348199

Ongoing Disease control Sponsor: Samsung Bioepis Co., Ltd. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 08, 2026 · Updated 4 times

Summary

This phase 3 trial tests whether SB27, a proposed biosimilar to the cancer drug Keytruda, works as well as the original in people with advanced non-squamous non-small cell lung cancer. About 555 participants will receive either SB27 or Keytruda plus chemotherapy every 3 weeks. The main goal is to compare tumor shrinkage rates at 24 weeks.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: SB27 (a proposed biosimilar to pembrolizumab, the drug in Keytruda)
What this could lead to: If SB27 works as well as Keytruda, it could offer a more affordable treatment option for advanced lung cancer patients.
What could go wrong: This is a biosimilar study, not a new drug. Even if SB27 matches Keytruda, it may not improve outcomes. The trial is still ongoing, and results are not yet available.

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Conditions

The condition(s) this trial relates to.

non-small cell lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

NON-SMALL CELL LUNG CANCER STAGE IV

Contacts and locations

Locations

SB Investigative Site

Banja Luka, Bosnia and Herzegovina
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Mostar, Bosnia and Herzegovina
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Sarajevo, Bosnia and Herzegovina
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Curitiba, Brazil
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Florianópolis, Brazil
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Ijuí, Brazil
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Natal, Brazil
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Pelotas, Brazil
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Rio de Janeiro, Brazil
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Santo André, Brazil
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Batumi, Georgia
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Düsseldorf, Germany
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Halle, Germany
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Moers, Germany
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Neuss, Germany
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Bangalore, India
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Bhubaneswar, India
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Erandwane, India
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Hyderabad, India
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Mumbai, India
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Sūrat, India
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Udaipur, India
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Himeji, Japan
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Iwakuni, Japan
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Izumi, Japan
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Kawachi-Nagano, Japan
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Kobe, Japan
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Kochi, Japan
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Sagamihara, Japan
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Tachikawa, Japan
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Takarazuka, Japan
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Toyonaka, Japan
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George Town, Malaysia
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Johor Bahru, Malaysia
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Kota Bharu, Malaysia
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Kuantan, Malaysia
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Lembah Pantai, Malaysia
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Putrajaya, Malaysia
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Aguascalientes, Mexico
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Guadalajara, Mexico
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Mexico City, Mexico
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Davao City, Philippines
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Makati City, Philippines
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Manila, Philippines
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Quezon City, Philippines
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San Juan City, Philippines
SB Investigative Site

Cluj-Napoca, Romania
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Craiova, Romania
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Iași, Romania
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Oradea, Romania
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Sibiu, Romania
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Suceava, Romania
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Kamenitz, Serbia
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Kragujevac, Serbia
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Niš, Serbia
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Leganés, Spain
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Málaga, Spain
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Ourense, Spain
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Oviedo, Spain
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Santiago de Compostela, Spain
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Seville, Spain
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Valencia, Spain
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Bangkok Noi, Thailand
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Khon Kaen, Thailand
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Adapazarı, Turkey (Türkiye)
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Bağcılar, Turkey (Türkiye)
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Balgat, Turkey (Türkiye)
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Çubuk, Turkey (Türkiye)
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Istanbul, Turkey (Türkiye)
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İzmit, Turkey (Türkiye)
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Kavaklıdere, Turkey (Türkiye)
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Konak, Turkey (Türkiye)
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Maltepe, Turkey (Türkiye)
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Seyhan, Turkey (Türkiye)
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Sivas, Turkey (Türkiye)
SB Investigative Site 1

Porto Alegre, Brazil
SB Investigative Site 1

Tbilisi, Georgia
SB Investigative Site 1

Jaipur, India
SB Investigative Site 1

Craiova, Romania
SB Investigative Site 1

Belgrade, Serbia
SB Investigative Site 1

Bangkok, Thailand
SB Investigative Site 1

Ankara, Turkey (Türkiye)
SB Investigative Site 2

Porto Alegre, Brazil
SB Investigative Site 2

Tbilisi, Georgia
SB Investigative Site 2

Jaipur, India
SB Investigative Site 2

Craiova, Romania
SB Investigative Site 2

Belgrade, Serbia
SB Investigative Site 2

Bangkok, Thailand
SB Investigative Site 2

Ankara, Turkey (Türkiye)
SB Investigative Site 3

Tbilisi, Georgia
SB Investigative Site 4

Tbilisi, Georgia
SB Investigative Site 5

Tbilisi, Georgia
SB Investigative Site 6

Tbilisi, Georgia

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