New radioactive drug targets Hard-to-Treat prostate cancer

NCT ID NCT05983198

First seen Sep 30, 2025 · Last updated May 16, 2026 · Updated 21 times

Summary

This study tests an experimental radioactive drug, 225Ac-PSMA-R2, in men with advanced prostate cancer that has spread. The drug seeks out and delivers radiation directly to cancer cells. The trial includes men whose cancer has stopped responding to hormone therapy and who have or have not received a similar radioactive treatment before. The main goals are to find the safest dose and see if the drug can shrink tumors.

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Contacts and locations

Locations

  • BAMF Health

    Grand Rapids, Michigan, 49503, United States

  • Mayo Clinic Rochester

    Rochester, Minnesota, 55905, United States

  • Novartis Investigative Site

    Darlinghurst, New South Wales, 2010, Australia

  • Novartis Investigative Site

    Montreal, Quebec, H2X 1R9, Canada

  • Novartis Investigative Site

    Montreal, Quebec, H3T 1E2, Canada

  • Novartis Investigative Site

    Dijon, Cote D Or, 21034, France

  • Novartis Investigative Site

    Clermont-Ferrand, 63011, France

  • Novartis Investigative Site

    Lyon, 69373, France

  • Novartis Investigative Site

    Nantes, 44093, France

  • Novartis Investigative Site

    Saint-Herblain, 44805, France

  • Novartis Investigative Site

    Vandœuvre-lès-Nancy, 54511, France

Conditions

Explore the condition pages connected to this study.