Lung cancer combo trial halted early – what we know
NCT ID NCT04585815
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This early-phase trial tested the immunotherapy drug sasanlimab combined with various targeted therapies in 34 people with advanced non-small cell lung cancer. The goal was to check safety and find the right doses. However, the study was terminated early, meaning we have limited data on how well these combinations work.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
sasanlimab (an immunotherapy drug) combined with other targeted drugs (encorafenib, binimetinib, axitinib, SEA-TGT)
What this could lead to
If successful, this could point toward new combination treatments for advanced non-small cell lung cancer, especially for patients with specific genetic mutations.
What could go wrong
The trial was terminated early, so results are limited. It was a small, early-phase study (phase 1b/2) focused on safety and dosing, not yet proving effectiveness. Combination therapies also carry higher risk of side effects.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Advent Health Orlando - Investigational Drug Services
Orlando, Florida, 32804, United States
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AdventHealth Celebration Infusion Center
Celebration, Florida, 34747, United States
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AdventHealth Medical Group Oncology Research at Celebration
Celebration, Florida, 34747, United States
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AdventHealth Orlando
Orlando, Florida, 32804, United States
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AdventHealth Orlando Infusion Center
Orlando, Florida, 32804, United States
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Antwerp University Hospital
Edegem, Antwerpen, 2650, Belgium
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Austin Health
Heidelberg, Victoria, 3084, Australia
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California Cancer Associates for Research and Excellence, Inc (cCARE)
Fresno, California, 93720, United States
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Chris O'Brien Lifehouse
Camperdown, New South Wales, 2050, Australia
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Chung Shan Medical University Hospital
Taichung, 40201, Taiwan
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City of Hope
Duarte, California, 91010, United States
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City of Hope Investigational Drug Services (IDS)
Duarte, California, 91010, United States
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Concord Hospital
Concord, New South Wales, 2139, Australia
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GenesisCare North Shore
St Leonards, New South Wales, 2065, Australia
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Henry Ford Hospital
Detroit, Michigan, 48202, United States
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Henry Ford Medical Center - Columbus
Novi, Michigan, 48377, United States
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Henry Ford Medical Center - Fairlane
Dearborn, Michigan, 48126, United States
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Icahn School of Medicine at Mount Sinai
New York, New York, 10029, United States
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Koman Family Outpatient Pavilion
La Jolla, California, 92037, United States
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Koo Foundation Sun Yat -Sen Cancer Center
Taipei, 112, Taiwan
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Koo Foundation Sun Yat-Sen Cancer Center
Taipei, 112, Taiwan
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Moffitt Cancer Center
Tampa, Florida, 33612, United States
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Mount Sinai Hospital Pharmacy
New York, New York, 10029, United States
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National Taiwan University Hospital
Taipei, 10002, Taiwan
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National Taiwan University Hospital
Taipei, 100, Taiwan
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North Shore Radiology and Nuclear Medicine
St Leonards, New South Wales, 2065, Australia
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Sarah Cannon Research Institute - Pharmacy
Nashville, Tennessee, 37203, United States
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Sulpizio Cardiovascular Center at UC San Diego Health
La Jolla, California, 92037, United States
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Tennessee Oncology PLLC
Dickson, Tennessee, 37055, United States
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Tennessee Oncology PLLC
Franklin, Tennessee, 37067, United States
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Tennessee Oncology PLLC
Gallatin, Tennessee, 37066, United States
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Tennessee Oncology PLLC
Hendersonville, Tennessee, 37075, United States
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Tennessee Oncology PLLC
Hermitage, Tennessee, 37076, United States
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Tennessee Oncology PLLC
Lebanon, Tennessee, 37090, United States
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Tennessee Oncology PLLC
Murfreesboro, Tennessee, 37129, United States
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Tennessee Oncology PLLC
Nashville, Tennessee, 37203, United States
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Tennessee Oncology PLLC
Nashville, Tennessee, 37205, United States
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Tennessee Oncology PLLC
Nashville, Tennessee, 37207, United States
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Tennessee Oncology PLLC
Nashville, Tennessee, 37211, United States
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Tennessee Oncology PLLC
Shelbyville, Tennessee, 37160, United States
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Tennessee Oncology PLLC
Smyrna, Tennessee, 37167, United States
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The Oncology Institute of Hope and Innovation
Glendale, California, 91204, United States
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The Oncology Institute of Hope and Innovation
Long Beach, California, 90805, United States
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The Oncology Institute of Hope and Innovation
Los Angeles, California, 90015, United States
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The Oncology Institute of Hope and Innovation
Santa Ana, California, 92705, United States
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The Oncology Institute of Hope and Innovation
Whittier, California, 90602, United States
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UC San Diego Medical Center - Hillcrest
San Diego, California, 92103, United States
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UC San Diego Medical Center - La Jolla (Jacobs Medical Center / Thornton Pavilion)
La Jolla, California, 92037, United States
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UC San Diego Moores Cancer Center
La Jolla, California, 92093, United States
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UC San Diego Moores Cancer Center - Investigational Drug Services
La Jolla, California, 92037, United States
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UCSD Medical Center - Encinitas
Encinitas, California, 92024, United States
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UCSD Medical Center - Vista
Vista, California, 92081, United States
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UCSD Perlman Medical Offices
La Jolla, California, 92037, United States
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USC/Norris Comprehensive Cancer Center
Los Angeles, California, 90033, United States
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UZ Leuven
Leuven, 3000, Belgium