Single shot could replace monthly eye injections for wet AMD

NCT ID NCT06660667

Ongoing Disease control Sponsor: Sanofi Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jul 17, 2026 · Updated 6 times

Summary

This study tests a new drug called SAR402663, given as a single injection into the eye, for people with wet age-related macular degeneration (AMD). The goal is to see if one dose can safely control the disease and reduce the need for frequent anti-VEGF injections. About 66 participants aged 50–90 will be followed for up to 5 years.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: SAR402663 (a biologic drug given as a one-time injection into the eye)
What this could lead to: If successful, this could mean fewer eye injections for people with wet AMD, potentially controlling the disease with a single dose instead of repeated treatments.
What could go wrong: This is an early-phase trial with only 66 participants, so safety and effectiveness are not yet proven. The one-time injection may not work for everyone, and there are risks like eye inflammation or infection.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

wet macular degeneration

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

NEOVASCULAR AGE-RELATED MACULAR DEGENERATION

Contacts and locations

Locations

Associated Retina Consultants - Phoenix- Site Number : 8400011

Phoenix, Arizona, 85020, United States
Austin Clinical Research - Austin - Anderson Mill Road- Site Number : 8400007

Austin, Texas, 78750, United States
Austin Research Center for Retina- Site Number : 8400015

Austin, Texas, 78705, United States
California Retina Consultants - Bakersfield- Site Number : 8400001

Bakersfield, California, 93309, United States
Charles Retina Institution- Site Number : 8400018

Germantown, Tennessee, 38138, United States
Charleston Neuroscience Institute - Ladson- Site Number : 8400016

Ladson, South Carolina, 29456, United States
Cumberland Valley Retina Consultants - Hagerstown- Site Number : 8400003

Hagerstown, Maryland, 21740, United States
Investigational Site Number : 8260024

London, Westminster, W1G 7LB, United Kingdom
Investigational Site Number : 8260027

Liverpool, L7 8XP, United Kingdom
Medical Center Ophthalmology Associates- Site Number : 8400030

San Antonio, Texas, 78240, United States
Mid Atlantic Retina- Site Number : 8400032

Bethlehem, Pennsylvania, 18017-9412, United States
North Carolina (Nc) Retina Associates - Wake Forest Office- Site Number : 8400033

Wake Forest, North Carolina, 27587-3803, United States
Ophthalmic Consultants of Boston - Boston- Site Number : 8400009

Boston, Massachusetts, 02114, United States
Oregon Retina- Site Number : 8400017

Eugene, Oregon, 97401, United States
Retina Consultants of Texas - The Woodlands- Site Number : 8400019

The Woodlands, Texas, 77384, United States
Retina Macula Institute of Arizona- Site Number : 8400028

Scottsdale, Arizona, 85255, United States
Retina Research Institute of Texas- Site Number : 8400008

Abilene, Texas, 79606, United States
Retina Specialist- Site Number : 8400020

Towson, Maryland, 21204, United States
Retina Vitreous Associates of Florida - St. Petersburg- Site Number : 8400002

St. Petersburg, Florida, 33711, United States
Retina-Vitreous Associates Medical Group - Beverly Hills- Site Number : 8400023

Beverly Hills, California, 90211, United States
Retinal Consultants of Texas - San Antonio- Site Number : 8400012

San Antonio, Texas, 78240, United States
Sierra Eye Associates- Site Number : 8400021

Reno, Nevada, 89502, United States
Southeast Retina Center- Site Number : 8400010

Augusta, Georgia, 30909, United States
Texas Retina Associates - Dallas- Site Number : 8400006

Dallas, Texas, 75231, United States
University Retina - Lemont- Site Number : 8400005

Lemont, Illinois, 60439, United States
Vitreo Retinal Associates - Gainesville- Site Number : 8400004

Gainesville, Florida, 32607, United States

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