New heart valve could save thousands from deadly narrowing
NCT ID NCT05172960
First seen May 23, 2026 · Last updated May 23, 2026
Summary
This study tests a new balloon-expandable heart valve (SAPIEN X4) in 1,234 people with severe aortic stenosis, a condition where the heart's main valve narrows. The goal is to see if the valve is safe and works well. Participants receive the valve through a tube in their leg, avoiding open-heart surgery.
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Alexian Brothers Hospital Network
Elk Grove Village, Illinois, 60007, United States
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Allegheny General Hospital
Pittsburgh, Pennsylvania, 15212, United States
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Atlantic Health System Morristown
Morristown, New Jersey, 07960, United States
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Bay Area Structural Heart at Sutter Health
San Francisco, California, 94109, United States
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Baylor Heart and Vascular Hospital
Dallas, Texas, 75226, United States
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Brigham and Women's Hospital
Boston, Massachusetts, 02115, United States
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Cardiovascular Research Institute of Kansas
Wichita, Kansas, 67226, United States
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Carolinas Health System
Charlotte, North Carolina, 28203, United States
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Cedars-Sinai Medical Center
Los Angeles, California, 90048, United States
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Centennial Medical Center
Nashville, Tennessee, 37203, United States
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CentraCare Heart and Vascular Center
Saint Cloud, Minnesota, 56303, United States
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Christchurch Hospital
Christchurch, 8011, New Zealand
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Columbia University Medical Center/NYPH
New York, New York, 10032, United States
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Cornell Medical Center
New York, New York, 10021, United States
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Dartmouth-Hitchcock Medical Center, Hanover
Lebanon, New Hampshire, 03756, United States
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Emory University Atlanta
Atlanta, Georgia, 30322, United States
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HCA Houston Healthcare Medical Center
Houston, Texas, 77004, United States
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Hamilton Health Services
Hamilton, Ontario, L8L 2X2, Canada
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Hartford Hospital
Hartford, Connecticut, 06102, United States
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Henry Ford Hospital
Detroit, Michigan, 48202, United States
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Hoag Memorial Hospital Presbyterian
Newport Beach, California, 92663, United States
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Institut Universitaire de Cardiologie et de Pneumologie de Quebec- Universite Laval
Québec, Quebec, G1V 4G5, Canada
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Kaiser Los Angeles
Los Angeles, California, 90027, United States
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Kaiser Portland
Clackamas, Oregon, 97015, United States
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Kaiser San Francisco Medical Center
San Francisco, California, 94115, United States
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Mayo Clinic Rochester
Rochester, Minnesota, 55905, United States
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Medical City Dallas Hospital
Dallas, Texas, 75230, United States
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Medstar Union Memorial Hospital
Baltimore, Maryland, 21218, United States
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Methodist Le Bonheur Healthcare
Germantown, Tennessee, 38138, United States
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Montefiore Medical Center
New York, New York, 10458, United States
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Naples Community Hospital Healthcare System
North Naples, Florida, 34102, United States
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NorthShore University HealthSystem Research Institute Evanston
Evanston, Illinois, 60201, United States
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Northwestern University Chicago
Evanston, Illinois, 60611, United States
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Novant Health and Heart Vascular Institute
Charlotte, North Carolina, 28204, United States
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Oklahoma Cardiovascular Research Group Oklahoma City
Oklahoma City, Oklahoma, 73120, United States
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Oklahoma Heart Institute
Tulsa, Oklahoma, 74104, United States
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Piedmont Heart Institute
Atlanta, Georgia, 30309, United States
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Pinnacle Health Harrisburg
Harrisburg, Pennsylvania, 17101, United States
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Providence Heart & Vascular Institute Portland
Portland, Oregon, 97225, United States
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Royal Adelaide Hospital
Adelaide, South Australia, 5000, Australia
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Rush University Medical Center Chicago
Chicago, Illinois, 60612, United States
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Rutgers Robert Wood Johnson Medical School
New Brunswick, New Jersey, 08901, United States
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Saint Luke's Hospital
Kansas City, Missouri, 64111, United States
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Saint Thomas Health
Nashville, Tennessee, 37205, United States
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Scripps Memorial Hospital La Jolla
La Jolla, California, 92037, United States
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Sentara Norfolk General Hospital
Norfolk, Virginia, 23507, United States
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Silver Cross Hospital
New Lenox, Illinois, 60541, United States
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St. Andrews War Memorial Hospital
Spring Hill, Queensland, 4000, Australia
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St. Patrick Hospital
Missoula, Montana, 59802, United States
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St. Paul's Hospital System
Vancouver, British Columbia, V6E 1M7, Canada
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St. Vincent Medical Group, Inc./ St. Vincent Heart Center of Indiana, LLC
Carmel, Indiana, 46290, United States
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Stanford University
Stanford, California, 94305, United States
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The Christ Hospital
Cincinnati, Ohio, 45219, United States
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The Cleveland Clinic Foundation
Cleveland, Ohio, 44195, United States
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The Heart Hospital Baylor Plano
Plano, Texas, 75093, United States
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The Royal Melbourne Hospital
Parkville, 3050, Australia
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The Valley Hospital
Ridgewood, New Jersey, 07450, United States
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UC Davis Medical Center Sacramento
Sacramento, California, 95817, United States
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UC Health Northern Colorado (Medical Center of the Rockies)
Loveland, Colorado, 80538, United States
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University at Buffalo - Kaleida Health
Buffalo, New York, 14203, United States
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University of Kansas Medical Center
Kansas City, Kansas, 66160, United States
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University of Texas Memorial Hermann
Houston, Texas, 77030, United States
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University of Washington Seattle
Seattle, Washington, 98195, United States
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Vanderbilt University Medical Center
Nashville, Tennessee, 37232, United States
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Washington University - Barnes-Jewish Hospital Saint Louis
St Louis, Missouri, 63110, United States
Conditions
Explore the condition pages connected to this study.