Weekly chemo boost could help ovarian cancer patients who Don't respond to standard treatment

NCT ID NCT06476184

Recruiting now Disease control Sponsor: ARCAGY/ GINECO GROUP Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Aug 05, 2026 · Updated 4 times

Summary

This phase 3 trial tests whether a denser weekly chemotherapy schedule (carboplatin every 3 weeks plus weekly paclitaxel) can help ovarian cancer patients whose tumors are not responding well to standard treatment. The study enrolls 250 adults with advanced ovarian cancer who have already had 3-4 cycles of standard chemo. The goal is to see if the weekly regimen makes more patients eligible for complete tumor removal surgery and improves overall survival.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Carboplatin and paclitaxel (chemotherapy drugs)
What this could lead to: If successful, this denser weekly chemo schedule could help more patients with hard-to-treat ovarian cancer become eligible for complete tumor removal surgery, potentially extending survival.
What could go wrong: This is a mid-stage trial with 250 participants, so results are not yet proven. The weekly regimen may cause more side effects like fatigue or low blood counts, and it may not improve outcomes for everyone.

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Conditions

The condition(s) this trial relates to.

fallopian tube carcinoma ovarian adenocarcinoma ovarian cancer primary peritoneal carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OVARIAN CANCER

Contacts and locations

Locations

Alessandro Manzoni Hospital
NOT_YET_RECRUITING

Lecco, 23900, Italy
Azienda Ospedaliero-Universitaria Di Bologna IRCCS Istituto Di Ricerca E Di Cura A Carattere Scientifico
RECRUITING

Bologna, 40138, Italy
Azienda Ospedaliero-Universitaria Ss.Antonio E Biagio E C.Arrigo Alessandria
NOT_YET_RECRUITING

Alessandria, 15121, Italy
Azienda Ulss 3 Serenissima
NOT_YET_RECRUITING

Venice, 30174, Italy
CH d'Avignon
RECRUITING

Avignon, 84902, France
CHRU Besançon - Hôpital Jean Minjoz
RECRUITING

Besançon, 25030, France
CHRU de Lille
NOT_YET_RECRUITING

Lille, 59000, France
CHRU de Montpellier - Hôpital Saint-Eloi
RECRUITING

Montpellier, 34059, France
CHU Saint-Etienne - Pôle de Cancérologie
RECRUITING

Saint-Priest-en-Jarez, 42271, France
CHU Strasbourg - Hôpital de Hautepierre
RECRUITING

Strasbourg, 67098, France
CHU de BREST - Hôpital Cavale Blanche
RECRUITING

Brest, 29200, France
CHU de Dijon
RECRUITING

Dijon, 21079, France
CHU de Limoges - Hôpital Dupuytren
RECRUITING

Limoges, 87042, France
Careggi University Hospital
NOT_YET_RECRUITING

Florence, 50134, Italy
Centre Antoine Lacassagne
RECRUITING

Nice, 06189, France
Centre Azuréen de Cancérologie
RECRUITING

Mougins, 06250, France
Centre Eugène Marquis
RECRUITING

Rennes, 35042, France
Centre François Baclesse
RECRUITING

Caen, 14076, France
Centre Georges François Leclerc
RECRUITING

Dijon, 21079, France
Centre Hospitalier Alpes Leman
NOT_YET_RECRUITING

Contamine-sur-Arve, 74130, France
Centre Hospitalier Général de Pau
RECRUITING

Pau, 64046, France
Centre Hospitalier Intercommunal de Créteil
RECRUITING

Créteil, 94010, France
Centre Hospitalier de Cholet
RECRUITING

Cholet, 49300, France
Centre Hospitalier de Valence
RECRUITING

Valence, 26953, France
Centre Jean Perrin
RECRUITING

Clermont-Ferrand, 63011, France
Centre Léon Bérard
RECRUITING

Lyon, 69373, France
Centre Oscar Lambret
RECRUITING

Lille, 59020, France
Centre d'Oncologie et de Radiothérapie 37 (ROC37)
RECRUITING

Chambray-lès-Tours, 37170, France
Clinique Pasteur
RECRUITING

Toulouse, 31300, France
Dokkyo Medical University Saitama Medical Center
NOT_YET_RECRUITING

Koshigaya, Japan
Erasmus Universitair Medisch Centrum Rotterdam (Erasmus MC)
NOT_YET_RECRUITING

Rotterdam, 3015 GJ, Netherlands
Fukushima Medical University Hospital
RECRUITING

Fukushima, Japan
Groupe Hospitalier Diaconesses - Croix Saint-Simon
RECRUITING

Paris, 75012, France
Groupe Hospitalier Mutualiste de Grenoble
RECRUITING

Grenoble, 38028, France
Gustave Roussy
RECRUITING

Villejuif, 94805, France
HCL - Centre Hospitalier Lyon Sud
RECRUITING

Pierre-Bénite, 69495, France
Het Nederlands Kanker Instituut-Antoni van Leeuwenhoek Ziekenhuis Stichting
NOT_YET_RECRUITING

Amsterdam, 1066 CX, Netherlands
Hirosaki University Hospital
NOT_YET_RECRUITING

Hirosaki, Japan
Hôpital André Mignot
RECRUITING

Le Chesnay, 78157, France
Hôpital Cochin
RECRUITING

Paris, 75014, France
Hôpital Européen George Pompidou
RECRUITING

Paris, 75015, France
Hôpital Foch
RECRUITING

Suresnes, 92151, France
Hôpital Privé Jean Mermoz
RECRUITING

Lyon, 69373, France
Hôpital Privé de la Loire
NOT_YET_RECRUITING

Saint-Etienne, 42100, France
Hôpital Privé du Confluent
RECRUITING

Nantes, 44202, France
Hôpital de Poissy-Saint-Germain-en-Laye
NOT_YET_RECRUITING

Poissy, 78303, France
Hôpital de la Croix Rousse
NOT_YET_RECRUITING

Lyon, 69229, France
Hôpital de la Côte Basque
RECRUITING

Bayonne, 64100, France
Hôpital de la Timone
NOT_YET_RECRUITING

Marseille, 13005, France
Hôpitaux du Léman - site Thonon-les-Bains
NOT_YET_RECRUITING

Thonon-les-Bains, 74203, France
ICANS - Institut de cancérologie Strasbourg Europe
RECRUITING

Strasbourg, 67033, France
ICM Val d'Aurelle
RECRUITING

Montpellier, 34298, France
ICO Paul Papin
RECRUITING

Angers, 49055, France
Institut Bergonié
RECRUITING

Bordeaux, 33076, France
Institut Curie
RECRUITING

Paris, 75248, France
Institut Jean Godinot
RECRUITING

Reims, 51056, France
Institut de Cancérologie de l'Ouest - ICO
RECRUITING

Saint-Herblain, 44805, France
Institut de Cancérologie du Gard - CHU de Nîmes
RECRUITING

Nîmes, 30029, France
Istituto Europeo Di Oncologia S.r.l.
RECRUITING

Milan, 20141, Italy
Kindai University Hospital
RECRUITING

Sayama, Japan
Kurume University Hospital
NOT_YET_RECRUITING

Kurume, Japan
Leids Universitair Medisch Centrum (LUMC)
NOT_YET_RECRUITING

Leiden, 2333 ZA, Netherlands
Nagoya University Hospital
RECRUITING

Nagoya, Japan
Oncopole Claudius Régaud - IUCT Oncopole
RECRUITING

Toulouse, 31059, France
Osaka Medical and Pharmaceutical University Hospital
NOT_YET_RECRUITING

Takatsuki, Japan
Radboud University Medical Center
NOT_YET_RECRUITING

Nijmegen, 6525 GA, Netherlands
Sainte-Catherine Institut du Cancer Avignon-Provence
RECRUITING

Avignon, 84918, France
Saitama Medical University International Medical Center
RECRUITING

Hidaka, Japan
St. Marianna University Hospital
RECRUITING

Kawasaki, Japan
The Cancer Institute Hospital Of JFCR
NOT_YET_RECRUITING

Tokyo, Japan
The Jikei University Daisan Hospital
NOT_YET_RECRUITING

Tokyo, Japan
The Jikei University Hospital
RECRUITING

Tokyo, Japan
The Jikei University Kashiwa Hospital
RECRUITING

Kashiwa, Japan
The Jikei University Katsushika Medical Center
NOT_YET_RECRUITING

Tokyo, Japan
The University of Tokyo Hospital
NOT_YET_RECRUITING

Bunkyō City, Japan
Tohoku University Hospital
RECRUITING

Sendai, Japan

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