New brain zaps show promise for tough-to-treat depression

NCT ID NCT05819021

First seen Jan 03, 2026 · Last updated May 16, 2026 · Updated 22 times

Summary

This study tests a treatment called SAINT® neuromodulation for people with major depression who haven't gotten better with medication. About 1000 adults will receive 10 sessions a day for 5 days. The goal is to see if this brain stimulation can ease depression symptoms.

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Contacts and locations

Locations

  • Acacia Research Center

    Sunnyvale, California, 94087, United States

  • Boston Precision Neurotherapeutics

    Natick, Massachusetts, 01760, United States

  • BrainHealth Solutions

    Costa Mesa, California, 92626, United States

  • Fermata

    Brooklyn, New York, 11249, United States

  • Integral TMS

    Sunnyvale, California, 94085, United States

  • LA TMS

    Los Angeles, California, 90025, United States

  • Seattle Neuropsychiatric Treatment Center

    Seattle, Washington, 98104, United States

Conditions

Explore the condition pages connected to this study.