New depression drug candidate passes first safety check in healthy volunteers

NCT ID NCT04981561

First seen Mar 25, 2026 · Last updated May 14, 2026 · Updated 13 times

Summary

This early-stage study tested the safety and tolerability of single doses of an experimental drug called AGN-241751 (zelquistinel) in 68 healthy volunteers. The goal was to see how the body handles the drug and if it causes any side effects, not to treat depression. The study is complete and helps pave the way for future research in people with major depressive disorder.

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