New frown line combo passes safety check in early trial

NCT ID NCT06834789

Completed Symptom relief Sponsor: AbbVie Source: ClinicalTrials.gov ↗

First seen Nov 17, 2025 · Last updated May 15, 2026 · Updated 16 times

Summary

This early-stage study tested the safety of combining two treatments (AGN-151586 and BOTOX) for moderate to severe frown lines between the eyebrows. 132 healthy adults received a single treatment and were monitored for side effects and immune reactions. The goal was to see if the combination is safe enough for further testing.

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Contacts and locations

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Locations

Austin Institute for Clinical Research - Pflugerville /ID# 270834

Pflugerville, Texas, 78660, United States
Eye Research Foundation /ID# 270827

Newport Beach, California, 92663, United States
Investigate MD /ID# 270771

Scottsdale, Arizona, 85260, United States
Marcus Facial Plastic Surgery /ID# 270770

Redondo Beach, California, 90277, United States
Skin Research Institute LLC /ID# 270831

Coral Gables, Florida, 33146-1837, United States
SkinDC /ID# 270932

Arlington, Virginia, 22209, United States
Skincare Physicians /ID# 271018

Chestnut Hill, Massachusetts, 02467, United States
Wilmington Dermatology Center /ID# 270828

Wilmington, North Carolina, 28403, United States

Conditions

Explore the condition pages connected to this study.

GLABELLAR LINES