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New radioactive drug aims to fight gut tumors that resist standard therapy

NCT ID NCT05477576

Recruiting now Disease control Sponsor: RayzeBio, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests a new drug called RYZ101 in people with advanced neuroendocrine tumors (GEP-NETs) that have grown after prior radiation therapy. The trial has two parts: first finding the right dose, then comparing RYZ101 to standard treatments like everolimus or sunitinib. About 338 participants will be enrolled to see if RYZ101 can slow tumor growth better than current options.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

RYZ101 (a radioactive drug targeting somatostatin receptors)

What this could lead to

If successful, RYZ101 could offer a new treatment option for people with advanced GEP-NETs whose cancer has worsened after initial targeted radiation therapy.

What could go wrong

This is an early-to-mid stage trial (Phase 1b/3), so results are not guaranteed. RYZ101 may not be more effective than standard treatments and could cause side effects from radiation exposure.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

Adenoma, Islet Cell carcinoid tumor digestive system neuroendocrine neoplasm digestive system neuroendocrine tumor, grade 1/2 neuroendocrine neoplasm pancreatic neuroendocrine tumor

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CARCINOID CARCINOID TUMOR GASTROENTEROPANCREATIC NEUROENDOCRINE TUMOR GASTROENTEROPANCREATIC NEUROENDOCRINE TUMOR DISEASE GEP-NET NEUROENDOCRINE TUMORS PANCREATIC NET

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Research Facility

    ACTIVE_NOT_RECRUITING

    Phoenix, Arizona, 85054, United States

  • Research Facility

    COMPLETED

    Duarte, California, 91010, United States

  • Research Facility

    RECRUITING

    Irvine, California, 92663, United States

    Contact

  • Research Facility

    ACTIVE_NOT_RECRUITING

    Los Angeles, California, 90095, United States

  • Research Facility

    ACTIVE_NOT_RECRUITING

    Palo Alto, California, 94305, United States

  • Research Facility

    ACTIVE_NOT_RECRUITING

    San Francisco, California, 94143, United States

  • Research Facility

    ACTIVE_NOT_RECRUITING

    New Haven, Connecticut, 06510, United States

  • Research Facility

    ACTIVE_NOT_RECRUITING

    Washington D.C., District of Columbia, 20010, United States

  • Research Facility

    ACTIVE_NOT_RECRUITING

    Jacksonville, Florida, 32224, United States

  • Research Facility

    RECRUITING

    Miami, Florida, 33165, United States

    Contact

  • Research Facility

    RECRUITING

    Tampa, Florida, 33607, United States

    Contact

  • Research Facility

    ACTIVE_NOT_RECRUITING

    Atlanta, Georgia, 30322, United States

  • Research Facility

    RECRUITING

    Iowa City, Iowa, 52242, United States

    Contact

  • Research Facility

    RECRUITING

    Lexington, Kentucky, 40536, United States

    Contact

  • Research Facility

    RECRUITING

    Glen Burnie, Maryland, 21061, United States

    Contact

  • Research Facility

    ACTIVE_NOT_RECRUITING

    Boston, Massachusetts, 02118, United States

  • Research Facility

    ACTIVE_NOT_RECRUITING

    Boston, Massachusetts, 02215, United States

  • Research Facility

    COMPLETED

    Troy, Michigan, 48098, United States

  • Research Facility

    ACTIVE_NOT_RECRUITING

    Rochester, Minnesota, 55905, United States

  • Research Facility

    RECRUITING

    St Louis, Missouri, 63110, United States

    Contact

  • Research Facility

    RECRUITING

    Omaha, Nebraska, 68130, United States

    Contact

  • Research Facility

    ACTIVE_NOT_RECRUITING

    New York, New York, 10029, United States

  • Research Facility

    RECRUITING

    New York, New York, 10065, United States

    Contact

  • Research Facility

    ACTIVE_NOT_RECRUITING

    Cleveland, Ohio, 44106, United States

  • Research Facility

    RECRUITING

    Columbus, Ohio, 43221, United States

    Contact

  • Research Facility

    ACTIVE_NOT_RECRUITING

    Portland, Oregon, 97239, United States

  • Research Facility

    ACTIVE_NOT_RECRUITING

    Philadelphia, Pennsylvania, 19104, United States

  • Research Facility

    RECRUITING

    Pittsburgh, Pennsylvania, 15232, United States

    Contact

  • Research Facility

    ACTIVE_NOT_RECRUITING

    Nashville, Tennessee, 37232, United States

  • Research Facility

    ACTIVE_NOT_RECRUITING

    Houston, Texas, 77030, United States

  • Research Facility

    RECRUITING

    Salt Lake City, Utah, 84112, United States

    Contact

  • Research Facility

    RECRUITING

    Seattle, Washington, 98109, United States

    Contact

  • Research Facility

    RECRUITING

    Brussels, Belgium

    Contact

  • Research Facility

    ACTIVE_NOT_RECRUITING

    Leuven, Belgium

  • Research Facility

    ACTIVE_NOT_RECRUITING

    Roeselare, Belgium

  • Research Facility

    ACTIVE_NOT_RECRUITING

    Brasília, Brazil

  • Research Facility

    COMPLETED

    Rio de Janeiro, Brazil

  • Research Facility

    ACTIVE_NOT_RECRUITING

    São Paulo, Brazil

  • Research Facility

    ACTIVE_NOT_RECRUITING

    London, Ontario, Canada

  • Research Facility

    ACTIVE_NOT_RECRUITING

    Toronto, Ontario, M4N 3M5, Canada

  • Research Facility

    ACTIVE_NOT_RECRUITING

    Montreal, Quebec, Canada

  • Research Facility

    RECRUITING

    Clichy, France

    Contact

  • Research Facility

    RECRUITING

    Lille, France

    Contact

  • Research Facility

    ACTIVE_NOT_RECRUITING

    Montpellier, France

  • Research Facility

    ACTIVE_NOT_RECRUITING

    Nantes, France

  • Research Facility

    RECRUITING

    Vandœuvre-lès-Nancy, France

    Contact

  • Research Facility

    ACTIVE_NOT_RECRUITING

    Villejuif, France

  • Research Facility

    RECRUITING

    Amsterdam, Netherlands

    Contact

  • Research Facility

    ACTIVE_NOT_RECRUITING

    Maastricht, Netherlands

  • Research Facility

    RECRUITING

    Utrecht, Netherlands

    Contact

  • Research Facility

    ACTIVE_NOT_RECRUITING

    Seoul, South Korea

  • Research Facility

    RECRUITING

    Barcelona, Spain

    Contact

  • Research Facility

    RECRUITING

    Madrid, Spain

    Contact

  • Research Facility

    COMPLETED

    Zaragoza, Spain