Promising new combo tackles rare immune storm in kids
NCT ID NCT04551131
First seen Nov 01, 2025 · Last updated May 01, 2026 · Updated 26 times
Summary
This study tests a combination of three drugs (ruxolitinib, dexamethasone, and etoposide) for hemophagocytic lymphohistiocytosis (HLH), a rare and life-threatening immune disorder. The treatment is adjusted based on how well each patient responds. The trial includes up to 10 children and young adults (ages 6 weeks to 22 years) with newly diagnosed or relapsed HLH. The goal is to see if this approach can control the disease with fewer severe side effects.
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Children's Hospital of Orange County
Orange, California, 92868, United States
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Children's Hospital of Philadelphia
Philadelphia, Pennsylvania, 19104, United States
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Children's National Medical Center
Washington D.C., District of Columbia, 20010, United States
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Children's Wisconsin/Medical College of Wisconsin
Milwaukee, Wisconsin, 53226, United States
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Cohen Children's Medical Center
New Hyde Park, New York, 11040, United States
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Dana-Farber Cancer Institute
Boston, Massachusetts, 02215, United States
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John Hopkins University
Baltimore, Maryland, 21287, United States
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Levine Children's Hospital
Charlotte, North Carolina, 28203, United States
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Phoenix Children's Hospital
Phoenix, Arizona, 85016, United States
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St. Jude Children's Research Hospital
Memphis, Tennessee, 38105, United States
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Texas Children's Hospital
Houston, Texas, 77030, United States
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University of California San Francisco
San Francisco, California, 94158, United States
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University of Texas Southwestern Medical Center
Dallas, Texas, 75235, United States
Conditions
Explore the condition pages connected to this study.