New hope for toughest childhood leukemia cases

NCT ID NCT02723994

Completed Disease control Sponsor: Incyte Corporation Source: ClinicalTrials.gov ↗

Summary

This study tested whether adding the drug ruxolitinib to standard chemotherapy could help children with a particularly aggressive form of acute lymphoblastic leukemia (ALL). It involved 171 children and young adults (ages 1-21) who had specific genetic markers that make their cancer harder to treat. The first part of the study aimed to find the safest dose, and the second part measured how well the combination worked to keep patients cancer-free for three years.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Locations

Akron Children'S Hospital

Akron, Ohio, 44308, United States
Albany Medical College

Albany, New York, 12208, United States
Alberta'S Children Hospital

Calgary, Alberta, T3B 6A8, Canada
Alfred I. Dupont Hospital For Children

Wilmington, Delaware, 19803, United States
All Childrens Hospital

St. Petersburg, Florida, 33701, United States
Alliance For Childhood Diseases

Las Vegas, Nevada, 89109, United States
Ann & Robert H. Lurie Children'S Hospital

Chicago, Illinois, 60611, United States
Arkansas Childrens Hospital

Little Rock, Arkansas, 72202, United States
Arnold Palmer Hospital For Children

Orlando, Florida, 32806, United States
Bc Children'S Hospital

Vancouver, British Columbia, V6G1R8, Canada
Blank Childrens Hospital

Des Moines, Iowa, 50309, United States
Carolinas Medical Center

Charlotte, North Carolina, 28203, United States
Children'S Center For Cancer & Blood Dis

Las Vegas, Nevada, 89109, United States
Children'S Hospital & Medical Center

Omaha, Nebraska, 68114, United States
Children'S Hospital Colorado

Aurora, Colorado, 80045, United States
Children'S Hospital Los Angeles

Los Angeles, California, 90027, United States
Children'S Hospital of Philadelphia

Philadelphia, Pennsylvania, 19104, United States
Children'S Hospital of the

Norfolk, Virginia, 23507, United States
Children'S Hospitals and Clinics of Minnesota

Minneapolis, Minnesota, 55404, United States
Childrens Hospital of Pittsburgh

Pittsburgh, Pennsylvania, 15224, United States
Childrens Hospital of Southwest Florida

Fort Myers, Florida, 33908, United States
Choc Children Hospital

Orange, California, 92868, United States
Chu Sainte-Justine

Montreal, Quebec, H3T 1C5, Canada
Cincinnati Childrens Hospital Medical Center

Cincinnati, Ohio, 45229, United States
Cleveland Clinic Foundation

Cleveland, Ohio, 44195, United States
Cohen Children'S Medical Center

New Hyde Park, New York, 11040, United States
Connecticut Children'S Medical Ctr

Hartford, Connecticut, 06106, United States
Cs Mott Childrens Hospital

Ann Arbor, Michigan, 48109, United States
Dana Farber Boston Children'S

Boston, Massachusetts, 02215, United States
Dayton Children'S Hospital

Dayton, Ohio, 45404, United States
Dell Childrens Medical Center of Central Texas

Austin, Texas, 78723, United States
Doernbecher Childrens Hospital

Portland, Oregon, 97239, United States
Driscoll Children'S Hospital

Corpus Christi, Texas, 78411, United States
Egleston Children'S Health

Atlanta, Georgia, 30322-1060, United States
El Paso Children'S Hospital Corporation

El Paso, Texas, 79905, United States
Florida Hospital Orlando

Orlando, Florida, 32803, United States
Hackensack University Medical Center

Hackensack, New Jersey, 07601, United States
Hasbro Childrens Hospital

Providence, Rhode Island, 02903, United States
Helen Devos Childrens Hosp

Grand Rapids, Michigan, 49503, United States
Joe Dimaggio Children Hospital

Hollywood, Florida, 33021, United States
Johns Hopkins University

Baltimore, Maryland, 21287-7049, United States
Kaiser Foundation Health Plan

Los Angeles, California, 90027, United States
Kaiser Permanente

Fontana, California, 92335, United States
Kaiser Permanente

San Diego, California, 92111, United States
Kaiser Permanente Downey

Santa Fe Springs, California, 90670, United States
Kapiolani Medical Center For Women and Children

Honolulu, Hawaii, 96826, United States
Kosair Childrens Hospital

Louisville, Kentucky, 40202, United States
Legacy Emanuel Hospital and Health Center

Portland, Oregon, 97227, United States
Loma Linda University Cancer Center

Loma Linda, California, 92350, United States
Loyola University Medical Center

Maywood, Illinois, 60153-3328, United States
Lucille Packard Childrens Hospital

Palo Alto, California, 94304, United States
Maine Center For Cancer Medicine

Scarborough, Maine, 04074, United States
McGill University Health Centre/Glen Site/Cedars Cancer Centre

Montreal, Quebec, H4A 3J1, Canada
McMaster University Medical Centre

Hamilton, L8V 5C2, Canada
Medical City Dallas Hospital

Dallas, Texas, 75230, United States
Medical College of Wisconsin

Milwaukee, Wisconsin, 53226, United States
Medical University of South Carolina

Charleston, South Carolina, 29425, United States
Michigan State University

Lansing, Michigan, 48912, United States
Miller Childrens Hospital Pharmacy

Long Beach, California, 90806, United States
Morristown Medical Center

Morristown, New Jersey, 07962, United States
Nationwide Children'S Hospital

Columbus, Ohio, 43205, United States
Nemours Childrens Clinic

Jacksonville, Florida, 32207, United States
Nemours Childrens Clinic

Pensacola, Florida, 32504, United States
New York Medical College

Valhalla, New York, 10595, United States
Newark Beth Israel Medical Center

Newark, New Jersey, 07112, United States
Nyu Clinical Cancer Center

New York, New York, 10032, United States
Ochsner Clinic

New Orleans, Louisiana, 70121, United States
Penn State Hershey Medical Center

Hershey, Pennsylvania, 17033-2360, United States
Phoenix Children'S Hospital

Phoenix, Arizona, 85016-7710, United States
Primary Children'S Hospital

Salt Lake City, Utah, 84113, United States
Providence Sacred Heart Medical Center & Children'S Hospital

Spokane, Washington, 99204, United States
Rady Children'S Hospital - San Diego

San Diego, California, 92123, United States
Rainbow Babies & Children Hosp

Cleveland, Ohio, 44106, United States
Riley Hospital For Children

Indianapolis, Indiana, 46202, United States
Roswell Park Comprehensive Cancer Center

Buffalo, New York, 14263, United States
Rutgers Cancer Institute of Nj

New Brunswick, New Jersey, 08901, United States
Saint Marys Medical Center

West Palm Beach, Florida, 33407, United States
San Jorge Childrens Hospital

San Juan, 00912, Puerto Rico
Seattle Children'S Hospital

Seattle, Washington, 98105, United States
Sinai Hospital of Baltimore

Baltimore, Maryland, 21215, United States
Smilow Cancer Center - Yale

New Haven, Connecticut, 06510, United States
Southern California Permanente Medical Group

Los Angeles, California, 90027, United States
Southern Illinois University School of Medicine

Springfield, Illinois, 62702, United States
St Josephs Childrens Hospital Tampa

Tampa, Florida, 33607, United States
St Josephs Regional Medical Center

Paterson, New Jersey, 07503, United States
St Vincent Hospital

Indianapolis, Indiana, 46260, United States
St Vincent Hospital

Green Bay, Wisconsin, 54301, United States
Suny Upstate Medical University

Syracuse, New York, 13210, United States
Texas Childrens Hospital

Houston, Texas, 77030, United States
The Children'S Mercy Hospital Outpatient

Kansas City, Missouri, 64108, United States
The Childrens Hospital of Alabama

Birmingham, Alabama, 35233, United States
The Hospital For Sick Children

Toronto, Ontario, 94611, Canada
Toledo Hospital

Toledo, Ohio, 43606, United States
Ucsf Pediatric Oncology

San Francisco, California, 94158, United States
University Pediatric Hospital

San Juan, PR, 00930, Puerto Rico
University of Florida Health Shands Hospital

Jacksonville, Florida, 32209, United States
University of Iowa Hospital and Clinics

Iowa City, Iowa, 52242, United States
University of Kentucky

Lexington, Kentucky, 40536, United States
University of Minnesota

Minneapolis, Minnesota, 55455, United States
University of Mississippi Medical Center

Jackson, Mississippi, 39216, United States
University of New Mexico Hospital

Albuquerque, New Mexico, 87131, United States
University of North Carolina At Chapel Hill

Chapel Hill, North Carolina, 27514, United States
University of Oklahoma Health Sciences Center

Oklahoma City, Oklahoma, 73104, United States
University of Rochester Medical Center

Rochester, New York, 14642, United States
University of Texas Health Science Cente

San Antonio, Texas, 78229, United States
University of Texas Southwestern Medical Center

Dallas, Texas, 75390, United States
Valley Childrens Hospital

Madera, California, 93636-8762, United States
Vanderbilt University Medical Center

Nashville, Tennessee, 37232, United States
Wake Forest University

Winston-Salem, North Carolina, 27157, United States
Washington University

St Louis, Missouri, 63130, United States
Weill Cornell Medical College

New York, New York, 10021, United States

Conditions

Explore the condition pages connected to this study.

LEUKEMIA