Can a JAK-Inhibitor cream recolor white patches caused by cancer treatment?

NCT ID NCT07725432

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 24, 2026 · Last updated Jul 24, 2026

Summary

This study tests whether a topical cream containing ruxolitinib can safely restore skin color in people who develop white patches (vitiligo-like depigmentation) as a side effect of cancer immunotherapy. The cream is applied twice daily for 52 weeks. Researchers will measure how much color returns to the face and body. The trial includes 34 adults with at least 5% body surface area affected.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
a topical cream containing ruxolitinib, a JAK inhibitor
What this could lead to
If effective, this cream could become the first approved treatment for white patches caused by cancer immunotherapy, helping restore skin color.
What could go wrong
This is a small, early-phase trial with only 34 participants. Previous studies in other forms of vitiligo showed improvement in about half of patients, but results may differ for this specific cause.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

About 34 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jul 2024

Expected to finish

Aug 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: Adult patients eligible for this inclusion in this study have to fulfil all the following criteria: * Age 18 years * Written informed consent of the patient * Sufficient fluency in German language skills to complete all questionnaires of the study without external assistance * Treatment-related, immune-related vitiligo-like depigmentation of at least 5% body surface area of one region (face or one upper or lower extremity or front or back side of the trunk) * Female participants must use effective contraceptives, either: An ovulation-inhibiting method (e.g., pill, injectable, implant, patch, or vaginal ring) or an intrauterine device (IUD). Contraception should extend one week post-study. If pregnancy occurs during or within one week after the study, participants should notify the overseeing physician immediately. * During participation in the study and up to one week afterwards, male participants may only have sexual intercourse with condoms. Female partners of male participants must use a highly effective contraceptive method during the partner's participation in the study and for up to 1 week afterwards Exclusion Criteria: Patients fulfilling any of the following criteria are not eligible for the inclusion in this study: * Acute psychiatric illness (except mild to moderate depression) * Contraindications to ruxolitinib, e.g. known hypersensitivity or allergy * Use of topical glucocorticosteroids, topical calcineurin inhibitors, UV light therapy, therapeutic biologics, other JAK inhibitors or potent immunosuppressants such as azathioprine or cyclosporine are not allowed during the study period (no wash out period required). * Women who are pregnant or breast feeding * Intention to become pregnant during the course of the study * Known or suspected non-compliance, drug or alcohol abuse. * Patients with an active, serious infection, including localized infections. * Inability to follow the procedures of the study due to language problems, psychological disorders, dementia of the participant. * Participation in another trial with topical or oral ruxolitinib within the 30 days preceding and during the present study. * Simultaneously participation in clinical trials with intervention with a drug other than ruxolitinib (except registry studies) * Previous enrolment into the current study. * Enrolment of the investigator, his/her family members, employees and other dependent persons.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Universitätsspital Zürich

    Zurich, 8058, Switzerland