Modified cold sore virus injected into tumors in early cancer trial

NCT ID NCT04336241

Summary

This is an early-stage safety study testing a new treatment called RP2, which is a genetically modified cold sore virus designed to kill cancer cells and boost the immune system. It is being given alone and in combination with an existing immunotherapy drug (nivolumab) to adults with advanced solid tumors that have stopped responding to standard treatments. The main goals are to find a safe dose and see if the treatment shows any early signs of shrinking tumors.

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Contacts and locations

Locations

  • Churchill Hospital

    Oxford, OX3 9DU, United Kingdom

  • Hospital Clinico de Valencia

    Valencia, 46010, Spain

  • Hospital Universitario HM Sanchinarro

    Madrid, 10 28050, Spain

  • Hospital Universitario d'Hebron

    Barcelona, 119 08035, Spain

  • The Clatterbridge Cancer Centre NHS Foundation Trust

    Bebington, Merseyside, CH63 4JY, United Kingdom

  • The Royal Marsden NHS Foundation Trust

    London, SW3 6JJ, United Kingdom

Conditions

Explore the condition pages connected to this study.