New hope for frail elderly lymphoma patients: Chemo-Free combo trial launches
NCT ID NCT06835530
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This phase 2 trial is testing a combination of two drugs, rituximab and golcadomide, as a first treatment for older frail patients with diffuse large B-cell lymphoma who cannot have standard chemotherapy. The study aims to see if this chemo-free approach can control the cancer and improve survival. About 47 participants will be enrolled across multiple centers in Italy.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- rituximab and golcadomide (CC-99282)
- What this could lead to
- If this works, it could offer a gentler, chemo-free treatment option for older frail patients with diffuse large B-cell lymphoma who cannot tolerate standard chemotherapy.
- What could go wrong
- This is a small, early-phase (phase 2) study with only 47 participants, so results may not apply broadly. The combination may still cause side effects or fail to control the disease long-term.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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A.O.U. Città della Salute e della Scienza di Torino - Ematologia Universitaria
RECRUITINGTorino, Italy
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A.O.U. Città della Salute e della Scienza di Torino - S.C. Ematologia
RECRUITINGTorino, Italy
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AOU Integrata di Verona - U.O. Ematologia
RECRUITINGVerona, Italy
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AOU Ospedali Riuniti - Clinica di Ematologia
RECRUITINGAncona, Italy
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AOU SS. Antonio e Biagio e Cesare Arrigo di Alessandria - SCDU Ematologia
RECRUITINGAlessandria, 15121, Italy
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AOU Senese - U.O.C. Ematologia
NOT_YET_RECRUITINGSiena, Italy
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ASST Grande Ospedale Metropolitano Niguarda - SC Ematologia
RECRUITINGMilan, Italy
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ASST Spedali Civili di Brescia - Ematologia
RECRUITINGBrescia, Italy
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Azienda Ospedaliera S. Giuseppe Moscati - S.C. Ematologia e trapianto emopoietico
RECRUITINGAvellino, Italy
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Azienda Ospedaliera Universitaria Careggi -Unità Funzionale di Ematologia
RECRUITINGFlorence, Italy
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Azienda Sanitaria Locale di Pescara- Presidio Ospedaliero Santo Spirito - U.O.C. Ematologia
NOT_YET_RECRUITINGPescara, 65128, Italy
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Azienda Sanitaria Universitaria Giuliano Isontina (ASUGI) - S.C. Ematologia
RECRUITINGTrieste, Italy
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Azienda USL Piacenza - UOC Ematologia e Centro Trapianti,
RECRUITINGPiacenza, Italy
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Azienda Unità Sanitaria Locale-IRCCS - Arcispedale Santa Maria Nuova - Ematologia
RECRUITINGReggio Emilia, Italy
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Ematologia - Trapianto cellule staminali - Medicina Trasfusionale e Terapie Cellulari, Policlinico Universitario Campus Bio-Medico
RECRUITINGRoma, Italy
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Fondazione IRCCS San Gerardo dei Tintori -Ematologia
RECRUITINGMonza, Italy
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I.R.C.C.S. Istituto Oncologico Veneto -Oncologia 1
RECRUITINGPadova, Italy
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Ospedale IRCCS Centro di Riferimento Oncologico di Aviano - Divisione di Oncologia e dei Tumori immuno-correlati
RECRUITINGAviano, Italy
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Ospedale delle Croci - Ematologia
RECRUITINGRavenna, Italy
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Policlinico Giaccone - Ematologia
NOT_YET_RECRUITINGPalermo, Italy
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