New pill could help kids with severe hair loss regrow hair

NCT ID NCT07029711

Ongoing Disease control Sponsor: Pfizer Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests a daily oral medication called ritlecitinib in children aged 6 to 12 with severe alopecia areata, a condition causing significant hair loss. About 208 children will receive either a higher dose, lower dose, or placebo for 6 months. The goal is to see if the drug can safely regrow scalp hair.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

Ritlecitinib (oral capsule)

What this could lead to

If it works, this could offer a new treatment option for children with severe alopecia areata, helping regrow scalp hair.

What could go wrong

This is a Phase 3 trial, but results are not yet known. The drug may not work better than placebo, and side effects are possible. It is not a cure—treatment may need to continue.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

alopecia areata

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SEVERE ALOPECIA AREATA

Contacts and locations

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Locations

3A Research - West Location

El Paso, Texas, 79902, United States
Asst Spedali Civili Di Brescia

Brescia, 25123, Italy
Austin Institute for Clinical Research

Pflugerville, Texas, 78660, United States
Beijing Children's hospital, Capital Medical University

Beijing, Beijing Municipality, 100045, China
Beijing Tongren Hospital affiliated to Capital Medical University

Beijing, Beijing Municipality, 100730, China
CHU de Dijon Bourgogne

Dijon, 21079, France
Centre Hospitalier Universitaire de Nice - Hopital l'Archet 2

Nice, 06200, France
Centre Hospitalier Universitaire de Toulouse - Hôpital Larrey

Toulouse, 31400, France
Centrum Medyczne Angelius Provita

Katowice, Silesian Voivodeship, 40-611, Poland
Chelsea and Westminster Hospital NHS Foundation Trust

London, Greater London, SW10 9NH, United Kingdom
Chengdu Women and Children Center Hospital

Chengdu, Sichuan, 610091, China
Children's Hospital Colorado

Aurora, Colorado, 80045, United States
Children's National Medical Center

Washington D.C., District of Columbia, 20010, United States
Children's Wisconsin

Milwaukee, Wisconsin, 53226, United States
China-Japan Friendship Hospital

Beijing, Beijing Municipality, 100192, China
China-Japan Friendship Hospital

Beijing, 100029, China
Cityclinic Przychodnia Lekarsko-Psychologiczna Matusiak Spółka Partnerska

Wroclaw, Lower Silesian Voivodeship, 50-566, Poland
Complete Behavior Health (Dr. Brittany Marshall, Licensed Psychologist)

Papillion, Nebraska, 68046, United States
DERMEDIC Iwona Zdybska

Lublin, Lublin Voivodeship, 20-607, Poland
Dawes Fretzin Clinical Research Group, LLC

Indianapolis, Indiana, 46250, United States
Dell Children's Medical Center

Austin, Texas, 78723, United States
Dermoklinika - Centrum Medyczne spółka cywilna M. Kierstan, J. Narbutt, A. Lesiak

Lodz, Łódź Voivodeship, 90-436, Poland
Driscoll Children's Hospital

Corpus Christi, Texas, 78411, United States
Ear, Nose and Throat Consultants, LLC

Omaha, Nebraska, 68144, United States
Endeavor Health Clinical Operations

Evanston, Illinois, 60201, United States
Endeavor Health Clinical Operations

Skokie, Illinois, 60077, United States
Fakultní Nemocnice Brno

Brno, 613 00, Czechia
Fakultní nemocnice Bulovka

Praha 8 - Libeň, 180 81, Czechia
Fakultní nemocnice Plzeň

Pilsen, 30599, Czechia
GHICL - Hôpital Saint Vincent de Paul

Lille, 59020, France
GHICL - Service d'investigation - Recherche clinique

Lille, 59000, France
Great Ormond Street Hospital For Children NHS Foundation Trust

London, Greater London, WC1N 3JH, United Kingdom
Guy's and St Thomas' NHS Foundation Trust

London, Greater London, SE1 7EH, United Kingdom
Hamamatsu University Hospital

Hamamatsu, Shizuoka, 431-3192, Japan
Hangzhou Third Hospital

Hangzhou, Zhejiang, 310009, China
Hospices Civils de Lyon - CIC - Hopital Louis Pradel

Bron, 69500, France
Hospices Civils de Lyon - Hopital Femme Mere Enfant

Bron, 69500, France
Hospital Universitario Miguel Servet

Zaragoza, 50009, Spain
Hospital de la Santa Creu i Sant Pau

Barcelona, 08025, Spain
Huashan Hospital, Fudan University

Shanghai, Shanghai Municipality, 200040, China
Hunan Children's Hospital

Changsha, Hunan, 410007, China
IRCCS Azienda Ospedaliero-Universitaria di Bologna

Bologna, 40138, Italy
Kindred Hair and Skin Center

Marriottsville, Maryland, 21104, United States
Klinika Ambroziak Dermatologia

Warsaw, Masovian Voivodeship, 02-953, Poland
Klinika Osipowicz & Turkowski

Warsaw, Masovian Voivodeship, 00-716, Poland
Kunming Children's hospital

Kunming, Yunnan, 650103, China
Kyorin University Hospital

Mitaka, Tokyo, 181-8611, Japan
Labderm Essence Sp. Z o.o.

Ossy, Silesian Voivodeship, 42-624, Poland
Medical College of Wisconsin

Milwaukee, Wisconsin, 53226, United States
Medical University of South Carolina

Charleston, South Carolina, 29425, United States
Medical University of South Carolina Department of Dermatology and Dermatologic Surgery

Charleston, South Carolina, 29425, United States
Michigan Dermatology Institute

Waterford, Michigan, 48328, United States
Niigata University Medical & Dental Hospital

Niigata, Niigata, 951-8520, Japan
Northwest Dermatology Institute

Portland, Oregon, 97210, United States
Nzoz Specjalistyczny Ośrodek Dermatologiczny "Dermal"

Bialystok, Podlaskie Voivodeship, 15-453, Poland
Osaka Metropolitan University Hospital

Osaka, 545-8586, Japan
Państwowy Instytut Medyczny MSWiA

Warsaw, Masovian Voivodeship, 02-507, Poland
Pediatric Skin Research

Miami, Florida, 33156, United States
Penn State Health Milton S. Hershey Medical Center

Hershey, Pennsylvania, 17033, United States
Policlinico "G. Rodolico

Catania, 95123, Italy
Prof. MUDr. Petr Arenberger, DrSc., MBA

Prague, 11000, Czechia
Provita Poliklinika

Warsaw, Masovian Voivodeship, 02-647, Poland
Provita Sp. z o.o.

Katowice, Silesian Voivodeship, 40-611, Poland
Regents of the University of New Mexico

Albuquerque, New Mexico, 87131, United States
Royal Alexandra Children's Hospital

Brighton, EAST Sussex, BN2 5BE, United Kingdom
Royalderm Agnieszka Nawrocka

Warsaw, Masovian Voivodeship, 02-962, Poland
Shanghai Children's Hospital

Shanghai, 200062, China
Skin Specialists, PC dba Schlessinger MD

Omaha, Nebraska, 68144, United States
Southern California Clinical Research

Santa Ana, California, 92701, United States
Specjalistyczny Gabinet Dermatologiczny Aplikacyjno-Badawczy, Marek Brzewski, Paweł Brzewski s.c.

Krakow, Lesser Poland Voivodeship, 30-002, Poland
Texas Dermatology and Laser Specialists

San Antonio, Texas, 78218, United States
The First Affiliated Hospital of Guangzhou Medical University

Guangzhou, Guangdong, 510140, China
The First People's Hospital of Hangzhou

Hangzhou, Zhejiang, 310006, China
The Second Affiliated Hospital Chongqing Medical University

Chongqing, Chongqing Municipality, 400010, China
Tohoku University Hospital

Sendai, Miyagi, 980-8574, Japan
UCI Dermatology Clinical Research

Irvine, California, 92697, United States
University of New Mexico Health Sciences Center

Albuquerque, New Mexico, 87102, United States
University of New Mexico-IDS Pharmacy

Albuquerque, New Mexico, 87106, United States
Uniwersytecki Szpital kliniczny im. F. Chopina w Rzeszowie

Rzeszów, 35-055, Poland
Xiangya Hospital Central South University

Changsha, Hunan, 410008, China