New hope for tough stomach tumors: Head-to-Head drug battle

NCT ID NCT03673501

Ongoing Disease control Sponsor: Deciphera Pharmaceuticals, LLC Source: ClinicalTrials.gov ↗

Summary

This study compares two drugs, ripretinib and sunitinib, for patients with advanced gastrointestinal stromal tumors (GIST) whose cancer has worsened or who couldn't tolerate the standard first treatment, imatinib. About 453 patients worldwide will take one of the two drugs daily to see which one better controls tumor growth and extends life. The main goal is to see which drug keeps the cancer from progressing longer.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Locations

Ajou University Hospital

Suwon, South Korea
Antoni van Leeuwenhoek

Amsterdam, Netherlands
Asan Medical Center

Seoul, South Korea
Ashford Cancer Centre Research

Kurralta Park, South Australia, 5037, Australia
Ashford Cancer Centre Research

Kurralta Park, South Australia, Australia
Azienda Ospedaliera Universitaria Policlinico Sant'Orsola Malpighi

Bologna, Italy
Beatson West of Scotland Cancer Centre

Glasgow, United Kingdom
Border Medical Oncology Research Unit

Albury, New South Wales, Australia
CHU Poitiers-Hopital la Miletrie

Poitiers, France
CancerCare Manitoba

Winnipeg, Manitoba, Canada
Centre Georges François Leclerc

Dijon, France
Centre Hospitalier Universitaire Vaudois, Fondation du Centre Pluridisciplinaire d'Oncologi

Lausanne, Switzerland
Centre Léon Bérard

Lyon, France
Centre Oscar Lambret

Lille, France
Centrum Onkologii-Instytut im. M. Sklodowskiej Curie

Warsaw, Poland
Chang Gung Memorial Hospital

Linkou District, Taoyuan County, Taiwan
China Medical University Hospital

Taichung, Taiwan
Clinica San Carlos de Apoquindo Red Salud UC Christs

Santiago, Chile
Complejo Hospitalario Universitario de Vigo

Vigo, Spain
Cross Cancer Institute

Edmonton, Alberta, Canada
Dana Farber Cancer Institute

Boston, Massachusetts, 02215, United States
Debreceni Egyetem

Debrecen, Hungary
Duke University Medical Center

Durham, North Carolina, 27710, United States
Fakultni nemocnice v Motole

Prague, Czechia
Fondazione IRCCS Istituto Nazionale dei Tumori

Milan, Italy
Fox Chase Cancer Center

Philadelphia, Pennsylvania, 19111, United States
Froedtert Hospital-Medical College of Wisconsin

Milwaukee, Wisconsin, 53226, United States
Georgia Cancer Specialists

Sandy Springs, Georgia, 30342, United States
HELIOS Klinikum Berlin-Buch

Berlin, Germany
Henry Ford Health System

Detroit, Michigan, 48202, United States
Henry-Joyce Cancer Clinic

Nashville, Tennessee, 37232, United States
Hopital La Timone

Marseille, France
Hopital Maisonneuve-Rosemont

Québec, Canada
Hospital Clinico Universitario Virgen de la Victoria

Málaga, Spain
Hospital Universitari Vall d'Hebron

Barcelona, Spain
Hospital Universitario 12 de Octubre

Madrid, Spain
Hospital Universitario Clinico San Carlos

Madrid, Spain
Hospital Universitario HM Madrid Sanchinarro

Madrid, Spain
Hospital Universitario La Paz

Madrid, Spain
Hospital Universitario Ramon y Cajal

Madrid, Spain
Hospital Universitario Virgen del Rocio

Seville, Spain
Hospital de Basurto

Bilbao, Spain
Hospital de la Santa Creu i Sant Pau

Barcelona, Spain
ICO - Site René Gauducheau

Saint-Herblain, France
IGR

Paris, France
IOV - Istituto Oncologico Veneto IRCCS

Padua, Italy
IPC

Marseille, France
IU Simon Cancer Center

Indianapolis, Indiana, 46202, United States
Institut Bergonnié

Bordeaux, France
Institut Jules Bordet

Brussels, Belgium
Instituto Medicao Especializado Alexander Fleming

Buenos Aires, Argentina
Instituto Valenciano de Oncología,

Valencia, Spain
Johns Hopkins Hospital

Baltimore, Maryland, 21287, United States
Juravinski Cancer Centre

Hamilton, Ontario, Canada
Kaohsiung Chang Gung Memorial Hospital,

Kaohsiung City, Taiwan
Karolinska universitetssjukhuset

Solna, Sweden
Leiden University Medical Centre

Leiden, Netherlands
Magyar Honvedseg Egeszsegugyi Kozpont

Budapest, Hungary
Mayo Clinic

Rochester, Minnesota, 55905, United States
Mayo Clinic Florida

Jacksonville, Florida, 32224, United States
Mayo Clinic Scottsdale

Scottsdale, Arizona, 85259, United States
Memorial Sloan Kettering Cancer Center

New York, New York, 10065, United States
Miami Cancer Institute at Baptist Health, Inc.

Miami, Florida, 33176, United States
Moffitt Cancer Center

Tampa, Florida, 33612, United States
Montefiore Medical Center-Montefiore Medical Park

The Bronx, New York, 10467, United States
National Cancer Centre

Singapore, 169610, Singapore
National Chen Kung University Hospital

Tainan, Taiwan
Northwestern Memorial Hospital

Chicago, Illinois, 60611, United States
Norton Cancer Institute, Audubon Hospital Campus

Louisville, Kentucky, 40241, United States
Oregon Health & Science University Center for Health and Healing

Portland, Oregon, 97239, United States
Orlando Health UF Health Cancer Center

Orlando, Florida, 32806, United States
Oslo University Hospital

Oslo, Norway
Prince of Wales Hospital

Randwick, New South Wales, 2031, Australia
Princess Alexandara Hospital

Woolloongabba, Australia
Princess Alexandra Hospital

Woolloongabba, Queensland, Australia
Princess Margaret Cancer Centre

Toronto, Ontario, M5G 2C1, Canada
Rabin Medical Cente

Petah Tikva, Israel
Rocky Mountain Cancer Centers

Denver, Colorado, 80220, United States
Roswell Park Cancer Institute

Buffalo, New York, 43606, United States
Royal Marsden Hospital - Fulham

London, United Kingdom
Rutgers Cancer Institute

New Brunswick, New Jersey, 08901, United States
Samsung Medical Center

Seoul, South Korea
Sanatorio Allende

Córdoba, Córdoba Province, X5000JHQ, Argentina
Seoul National University Hospital

Seoul, South Korea
Shamir Medical Center (Assaf Harofeh)

Be’er Ya‘aqov, Israel
Smilow Cancer Hospital at Yale

New Haven, Connecticut, 06511, United States
St James's University Hospital

Leeds, United Kingdom
Stanford Medicine

Stanford, California, 94305, United States
Stephenson Cancer Center

Oklahoma City, Oklahoma, 73104, United States
Sylvester Comprehensive Cancer Center

Miami, Florida, 33136, United States
Taipei Veterans General Hospital

Taipei, Taiwan
Technische Universitat Dresden

Dresden, Germany
Tel-Aviv Sourasky Medical Center

Tel Aviv, Israel
Texas Oncology-Baylor Charles A. Sammons Cancer Center

Dallas, Texas, 75246, United States
The Alfred Hospital

Melbourne, Victoria, 3004, Australia
The Monter Cancer Center

Lake Success, New York, 11042, United States
The Netherlands Cancer Institute

Amsterdam, Netherlands
The Ohio State University Comprehensive Cancer Center - Arthur G. James Cancer Hospital and Solove Research Institute

Columbus, Ohio, 43210, United States
The Ottawa Hospital Cancer Centre

Ottawa, Ontario, Canada
UCLA Hematology Oncology Center - Main Site

Los Angeles, California, 90024, United States
UZ Leuven

Leuven, Belgium
Universita degli Studi di Palermo

Palermo, Italy
Universitaetsspital Zuerich, Klinik fuer Onkologie

Zurich, Switzerland
University College London Hospitals

London, United Kingdom
University Medical Center Groningen

Groningen, Netherlands
University of California San Diego Medical Center

La Jolla, California, 92103, United States
University of Chicago Medical Center

Chicago, Illinois, 60637, United States
University of Colorado Hospital - Anschutz Cancer Pavillion

Aurora, Colorado, 80045, United States
University of Iowa Hospital and Clinics

Iowa City, Iowa, 52242, United States
University of Minnesota Medical Center-Fairview

Minneapolis, Minnesota, 55455, United States
University of Texas MD Anderson Cancer Center

Houston, Texas, 77030, United States
University of Toledo

Toledo, Ohio, 43606, United States
University of Washington Medical Center

Seattle, Washington, 98195, United States
Università Campus Bio-Medico di Roma

Rome, Italy
Virginia Commonwealth University Massey Cancer Center

Richmond, Virginia, 23298, United States
Washington Cancer Institute at MedStar Washington Hospital Center

Washington D.C., District of Columbia, 20010, United States
Washington University School of Medicine - Siteman Cancer Center

St Louis, Missouri, 63110, United States
West German Cancer Center

Essen, Germany
Weston Park Hospital

Sheffield, United Kingdom
Winship Cancer Institute

Atlanta, Georgia, 30332, United States
stituto Scientifico Romagnolo Per Lo Studio e La Cura Dei Tumori

Meldola, Italy

Conditions

Explore the condition pages connected to this study.

GASTROINTESTINAL STROMAL TUMORS