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New pill aims to stop migraines before they start

NCT ID NCT05399485

Completed Prevention Sponsor: Pfizer Source: ClinicalTrials.gov ↗

First seen Nov 18, 2025 · Last updated May 14, 2026 · Updated 21 times

Summary

This study tested whether the drug rimegepant can help prevent migraines in Japanese adults. About 496 people with a history of migraines took either the drug or a placebo for 12 weeks. The main goal was to see if the drug reduced the number of migraine days per month compared to a placebo.

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Contacts and locations

Locations

  • Atago Hospital

    Kochi, Kochi, 780-0051, Japan

  • Atsuchi Neurosurgery Hospital

    Kagoshima, Kagoshima-ken, 892-0842, Japan

  • Doi Clinic Internal Medicine/Neurology

    Hiroshima, Hiroshima, 730-0031, Japan

  • Dokkyo Medical Univ. Hosp.

    Shimotsuga-gun, Tochigi, 321-0293, Japan

  • Fujitsu Clinic

    Nakahara, Kanagawa, 211-8588, Japan

  • Fukuuchi Pain Clinic

    Shinjuku-ku, Tokyo, 160-0017, Japan

  • Higashi Sapporo Neurology and Neurosurgery Clinic

    Sapporo, Hokkaido, 003-0003, Japan

  • Ikeda Neurosurgical Clinic

    Kasuga-shi, Fukuoka, 816-0824, Japan

  • Iwate Medical University Uchimaru Medical Center

    Morioka, Iwate, 020-8505, Japan

  • Japanese Red Cross Asahikawa Hospital

    Asahikawa-shi, Hokkaido, 070-8530, Japan

  • Japanese Red Cross Shizuoka Hospital

    Shizuoka, Shizuoka, 420-0853, Japan

  • Jinnouchi Neurosurgical Clinic

    Kasuga-shi, Fukuoka, 816-0802, Japan

  • Juntendo University Hospital

    Bunkyo-ku, Tokyo, 113-8431, Japan

  • Keio University Hospital

    Shinjuku-ku, Tokyo, 160-8582, Japan

  • Kijima Neurosurgery Clinic

    Kahoku-gun, Ishikawa-ken, 929-0342, Japan

  • Kindai University Hospital

    Osakasayama-shi, Osaka, 589-8511, Japan

  • Kitasato University Kitasato Institute Hospital

    Minato-ku, Tokyo, 108-8642, Japan

  • Konan Medical Center

    Higashinada-ku, Hyōgo, 658-0064, Japan

  • Makabe Clinic

    Okayama, Okayama-ken, 700-0964, Japan

  • Medical Corporation Seikokai Takanoko Hospital

    Matsuyama, Ehime, 790-0925, Japan

  • Medical Research Institute KITANO HOSPITAL, PIIF Tazuke-kofukai

    Osaka, Osaka, 530-8480, Japan

  • Mito Kyodo General Hospital

    Mito, Ibaraki, 310-0015, Japan

  • Nagamitsu Clinic

    Hofu-shi, Yamaguchi, 747-0802, Japan

  • Nagaseki Headache Clinic

    Kai-shi, Yamanashi, 400-0124, Japan

  • Nakamura Memorial Hospital

    Chūōku, Hokkaido, 060-8570, Japan

  • Nishinomiya Munic. Ctr. Hosp.

    Nishinomiya-shi, Hyōgo, 663-8014, Japan

  • Nishiogi Pain Clinic

    Suginami-ku, Tokyo, 167-0054, Japan

  • Okayama City General Medical Center Okayama City Hospital

    Okayama, Okayama-ken, 700-8557, Japan

  • Ooba Clinic for Neurosurgery & Headache

    Ōita, Oita Prefecture, 870-0831, Japan

  • SUBARU Health Insurance Society Ota Memorial Hospital

    Ota-shi, Gunma, 373-8585, Japan

  • Saiseikai Kumamoto Hospital

    Kumamoto, Kumamoto, 861- 4193, Japan

  • Saitama Medical University Hospital

    Iruma-gun, Saitama, 350-0495, Japan

  • Saitama Neuropsychiatric Institute

    Saitama-shi, Saitama, 338-8577, Japan

  • Sakura Neuro Clinic

    Toyama, Toyama, 930-0803, Japan

  • Sendai Headache and Neurology Clinic, Medical Corporation

    Sendai, Miyagi, 982-0014, Japan

  • Shinagawa Strings Clinic

    Minato-ku, Tokyo, 108-0075, Japan

  • St. Marianna Univ. Hospital

    Kawasaki-shi, Kanagawa, 216-8511, Japan

  • Takase Intern. Med. Clinic

    Toyonaka-shi, Osaka, 560-0012, Japan

  • Tanaka Neurosurgical Clinic

    Kagoshima, Kagoshima-ken, 892-0844, Japan

  • Tatsuoka Neurology Clinic

    Kyoto, Kyoto, 600-8811, Japan

  • Tokai univ. hachioji hosp.

    Hachioji-shi, Tokyo, 192-0032, Japan

  • Tominaga Clinic

    Osaka, Osaka, 556-0015, Japan

  • USUDA CLINIC for internal medicine

    Setagaya-ku, Tokyo, 156-0043, Japan

  • Umenotsuji Clinic

    Kochi, Kochi, 780-8011, Japan

Conditions

Explore the condition pages connected to this study.

MIGRAINE