Migraine drug may boost CAR-T therapy in tough lymphoma
NCT ID NCT07613788
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This Phase 2 trial tests whether adding the migraine drug rimegepant to a standard CAR-T cell therapy and another immunotherapy (glofitamab) can improve outcomes for people with high-risk relapsed or refractory large B-cell lymphoma. About 100 adults will be randomly assigned to receive the combination with or without rimegepant. The main goal is to see how many patients achieve a complete response (no detectable cancer) at 6 months after treatment.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Rimegepant, glofitamab, obinutuzumab, and CD19 CAR-T cells
What this could lead to
If successful, this combination could improve the chance of complete remission for patients with hard-to-treat lymphoma.
What could go wrong
This is an early Phase 2 trial with only 100 participants. The added benefit of rimegepant is unproven, and side effects from the combination may be significant.
Disclaimer
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Ruijin Hospital, Shanghai Jiao Tong University School of Medicine
Shanghai, China, 200020, China
Contact Phone: •••-•••-•••• Email: •••••@•••••