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New hope for Tough-to-Treat rheumatoid arthritis: experimental drug enters Mid-Stage trial

NCT ID NCT07137598

Recruiting now Disease control Sponsor: Hoffmann-La Roche Source: ClinicalTrials.gov ↗

First seen Sep 30, 2025 · Last updated May 17, 2026 · Updated 34 times

Summary

This study tests an experimental drug called Afimkibart (RO7790121) in 160 adults with moderate to severe rheumatoid arthritis who have not improved with or cannot tolerate standard treatments like TNF or JAK inhibitors. Participants will receive either the drug or a placebo to see if it reduces joint swelling and pain. The goal is to find a new option for controlling this chronic autoimmune disease.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • APRILLUS Asistencia e Investigacion

    RECRUITING

    Buenos Aires, Ciudad Autonoma Buenos Aires, C1406AGA, Argentina

  • Accurate Clinical Management

    RECRUITING

    Houston, Texas, 77089, United States

  • Accurate Clinical Research Inc.

    RECRUITING

    Lake Charles, Louisiana, 70605, United States

  • Altoona Center For Clinical Research

    RECRUITING

    Duncansville, Pennsylvania, 16635, United States

  • Barnet Hospital

    RECRUITING

    Barnet, EN5 3DJ, United Kingdom

  • Bispebjerg og Frederiksberg Hospital

    RECRUITING

    Frederiksberg, 2000, Denmark

  • CEPIC - Centro Paulista de Investigao Clnica e Servios Mdicos

    RECRUITING

    So Paulo, São Paulo, 04266-010, Brazil

  • CHU Strasbourg Hpital Hautepierre

    RECRUITING

    Strasbourg, Bas Rhin, 67091, France

  • Centro Medico Arsema

    RECRUITING

    Ciudad Autnoma de Buenos Aires, Buenos Aires, C1427, Argentina

  • Centro Mineiro de Pesquisa - CMIP

    RECRUITING

    Juiz de Fora, Minas Gerais, 36010-570, Brazil

  • Centro Privado de Medicina Familiar - Mind Out Research

    RECRUITING

    Ciudad Autonoma Buenos Aires, C1417EYH, Argentina

  • Centro de Estudos em Terapias Inovadoras ? CETI

    RECRUITING

    Curitiba, Paraná, 80030-110, Brazil

  • Centrum Kliniczno-Badawcze J. Brzezicki, B. Górnikiewicz-Brzezicka Lekarze Spó?ka Partne

    RECRUITING

    Elbl?g, 82-300, Poland

  • Centrum Medyczne Reuma Park

    RECRUITING

    Warsaw, 02-665, Poland

  • DM Clinical Research

    RECRUITING

    Tomball, Texas, 77375, United States

  • Doncaster Royal Infirmary

    RECRUITING

    Doncaster, South Yorkshire, DN2 5LT, United Kingdom

  • Fondazione Policlinico Universitario Agostino Gemelli IRCCS

    RECRUITING

    Rome, Lazio, 00168, Italy

  • HUB Erasme

    RECRUITING

    Brussels, 1070, Belgium

  • Hopital Lapeyronie

    RECRUITING

    Montpellier, Herault, 34295, France

  • Hopital Purpan

    RECRUITING

    Toulouse, Lot Et Garonne, 31059, France

  • Hopital de la Conception

    RECRUITING

    Marseille, Bouches-du-Rhne, 13005, France

  • Hospital Regional Universitario de Malaga

    RECRUITING

    Málaga, 29009, Spain

  • Hospital So Lucas da PUCRS

    RECRUITING

    Porto Alegre, Rio Grande do Sul, 90610-000, Brazil

  • Hospital Universitario Virgen Macarena

    RECRUITING

    Seville, 41009, Spain

  • Hospital das Clínicas FMRP-USP

    RECRUITING

    Ribeirão Preto, São Paulo, 14048-900, Brazil

  • Hpital Cochin

    RECRUITING

    Paris, 75014, France

  • IPC MT Instituto de Pesquisas Clinicas do Mato Grosso

    RECRUITING

    Cuiab, Mato Grosso, 78020-500, Brazil

  • Inland Rheumatology Clinical Trials Incorporated

    RECRUITING

    Upland, California, 91786, United States

  • L2IP ?Instituto de Pesquisas Clínicas Ltda.

    RECRUITING

    Brasília, Federal District, 70200-730, Brazil

  • Malopolskie Badania Kliniczne

    RECRUITING

    Krakow, 30-002, Poland

  • Narodowy Instytut Geriatrii, Reumatologii i Rehabilitacji im. Prof. Eleonory Reicher

    RECRUITING

    Warsaw, 02-637, Poland

  • North Tyneside General Hospital

    RECRUITING

    Newcastle upon Tyne, Tyne & Wear, NE29 8NH, United Kingdom

  • Nzoz Bif-Med

    RECRUITING

    Bytom, 41-902, Poland

  • Ohio State University Wexner Medical Center

    RECRUITING

    Columbus, Ohio, 43203, United States

  • Reumatop Spolka Jawna

    RECRUITING

    Wroclaw, 52-210, Poland

  • Rheumatic Disease Center

    RECRUITING

    Glendale, Wisconsin, 53217, United States

  • Rheumazentrum Ruhrgebiet

    RECRUITING

    Herne, North Rhine-Westphalia, 44649, Germany

  • Sjllands Universitetshospital

    RECRUITING

    Kge, 4600, Denmark

  • Städtisches Klinik Dresden-Friedrichstadt

    RECRUITING

    Dresden, Saxony, 01067, Germany

  • SunValley Arthritis Center Ltd.

    RECRUITING

    Peoria, Arizona, 85381, United States

  • Tidewater Clinical Research

    RECRUITING

    Chesapeake, Virginia, 23320, United States

  • Twoja Przychodnia NCM

    RECRUITING

    Nowa Sól, 67-100, Poland

  • UZ Leuven

    RECRUITING

    Leuven, 3000, Belgium

  • West Broward Rheumatology Associates, Inc.

    RECRUITING

    Tamarac, Florida, 33321, United States

  • Willow Rheumatology and Wellness PLLC

    RECRUITING

    Willowbrook, Illinois, 60527, United States

  • Zespol Poradni Specjalistycznych REUMED

    RECRUITING

    Lublin, 20-607, Poland

Conditions

Explore the condition pages connected to this study.

RHEUMATOID ARTHRITIS