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New hope for advanced liver cancer: experimental drug TTI-101 enters Mid-Stage trials

NCT ID NCT05440708

Recruiting now Disease control Sponsor: Tvardi Therapeutics, Incorporated Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a new oral drug called TTI-101 in people with advanced liver cancer that cannot be removed by surgery. The drug is given alone or combined with standard immunotherapy drugs. The main goals are to check safety and see if the drug shrinks tumors. About 193 adults will take part.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

hepatocellular carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEPATOCELLULAR CARCINOMA

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Barbara Ann Karmanos Cancer Institute

    RECRUITING

    Detroit, Michigan, 48201, United States

    Contact Phone: •••-•••-••••

  • Cleveland Clinic Lerner College of Medicine

    RECRUITING

    Cleveland, Ohio, 44195, United States

    Contact Phone: •••-•••-••••

  • DHR Health Institute for Research and Development

    RECRUITING

    McAllen, Texas, 78504, United States

    Contact Email: •••••@•••••

    Contact Email: •••••@•••••

  • Froedtert and Medical College of Wisconsin

    COMPLETED

    Milwaukee, Wisconsin, 53226, United States

  • Georgetown Lombardi Comprehensive Cancer Center

    COMPLETED

    Washington D.C., District of Columbia, 20007, United States

  • Harold C. Simmons Comprehensive Cancer Center

    RECRUITING

    Dallas, Texas, 75390, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Memorial Sloan Kettering Cancer Center - New York

    RECRUITING

    New York, New York, 10065, United States

    Contact

  • Moffitt Cancer Center

    RECRUITING

    Tampa, Florida, 33612, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Norris Comprehensive Cancer Center

    RECRUITING

    Los Angeles, California, 90033, United States

    Contact Email: •••••@•••••

  • Summit Cancer Centers - North Spokane

    RECRUITING

    Spokane, Washington, 99208, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • The Kirklin Clinic of University of Alabama Birmingham Hospital

    RECRUITING

    Birmingham, Alabama, 35233, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • The Sidney Kimmel Comprehensive Cancer Center

    RECRUITING

    Baltimore, Maryland, 21231, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • University of California Irvine Medical Center

    RECRUITING

    Orange, California, 92868, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • University of California San Diego

    COMPLETED

    La Jolla, California, 92093, United States

  • University of Colorado Hospital - Anschutz Medical Campus

    RECRUITING

    Aurora, Colorado, 80045, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • University of Michigan Rogel Cancer Center

    RECRUITING

    Ann Arbor, Michigan, 48109, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • University of Oklahoma Health Sciences Center

    RECRUITING

    Oklahoma City, Oklahoma, 73104, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • University of Texas Health Science Center - San Antonio

    RECRUITING

    San Antonio, Texas, 78229, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • University of Texas MD Anderson Cancer Center

    RECRUITING

    Houston, Texas, 77030-4000, United States

    Contact Email: •••••@•••••

  • Virginia Mason Medical Center

    RECRUITING

    Seattle, Washington, 98101, United States

    Contact Phone: •••-•••-••••

  • Washington University in St. Louis

    RECRUITING

    St Louis, Missouri, 63129, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact Phone: •••-•••-•••• Email: •••••@•••••

More trials for these conditions

Other studies related to the condition(s) this trial covers.