New study tests if diet and exercise can replace blood pressure pills
NCT ID NCT07424118
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests a 12-week program that combines a healthy diet, exercise, sleep, and stress management with a careful plan to reduce blood pressure medication. The goal is to see if people with high blood pressure can stop taking their pills and keep their blood pressure normal. The study involves 240 adults aged 40 to 65 with stable high blood pressure.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 240 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Apr 2026
An estimate. Start dates often move.
- Expected to finish
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Dec 2026
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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40 to 65 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria \<br\>\<br\> Men and women aged 40 to 65 years. \<br\>\<br\> Confirmed diagnosis of chronic essential hypertension established at least 6 months prior to enrollment. \<br\>\<br\> Stable antihypertensive pharmacological treatment for at least 3 months prior to enrollment, with no changes in medications or dosages. \<br\>\<br\> Blood pressure at screening ≤ 160/100 millimeters of mercury (mmHg). \<br\>\<br\> Ability and willingness to comply with the 12-week behavioral intervention, attend scheduled coaching sessions (60-minute group sessions and 10-minute rescue sessions), perform home blood pressure monitoring, and attend clinical visits according to the study schedule. \<br\>\<br\> Access to an electronic device with internet connectivity sufficient to participate in virtual coaching sessions and to receive and use the program digital materials. \<br\>\<br\> Exclusion Criteria \<br\>\<br\> Secondary hypertension. \<br\>\<br\> Use of antihypertensive medications for indications other than treatment of hypertension, or use of non-oral antihypertensive therapy. \<br\>\<br\> Medical conditions requiring mandatory continuation of antihypertensive therapy for indications other than blood pressure control, precluding medication reduction or withdrawal. \<br\>\<br\> Physical limitation preventing participation in light-to-moderate intensity physical activity. \<br\>\<br\> Body mass index (BMI) \< 18.5 kg/m² or clinical diagnosis of malnutrition. \<br\>\<br\> Hospitalization for any cardiovascular cause within 12 months prior to enrollment. \<br\>\<br\> Pregnancy, breastfeeding, or planned pregnancy during the study period. \<br\>\<br\> Participation in another interventional clinical study. \<br\>\<br\> Cognitive impairment, dementia, severe psychiatric disorder, or other condition that prevents adherence to study procedures or reliable communication with the research team. \<br\>\<br\> Alcohol or illicit substance abuse within the previous 12 months. \<br\>\<br\> Any medical condition that, in the investigator's opinion, compromises participant safety or the feasibility of medication deprescribing.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Universidad Abierta Interamericana
Buenos Aires, Buenos Aires, C1147AAU, Argentina
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