New hope for tough prostate cancers: adding chemo to targeted therapy
NCT ID NCT07333066
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times
Summary
This Phase 3 trial tests whether adding the chemotherapy drug docetaxel to the standard treatment (apalutamide plus hormone therapy) can help men with metastatic hormone-sensitive prostate cancer who did not have a strong initial response to apalutamide alone. About 320 men will be randomly assigned to receive either the standard treatment or the intensified combo. The goal is to see if the combo delays cancer progression or death.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
docetaxel and apalutamide
What this could lead to
If successful, this could offer a more effective treatment strategy for men with metastatic prostate cancer who do not respond well to initial therapy, potentially delaying disease progression.
What could go wrong
This is an early-stage Phase 3 trial with 320 participants, so results may not apply to all patients. Adding chemotherapy (docetaxel) increases side effects like fatigue, infection risk, and nerve damage.
Disclaimer
Read more
Show less
This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for METASTATIC HORMONE-SENSITIVE PROSTATE CANCER are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Show contact details
Enter your email to view the contact information for this study.
By submitting, you agree to our Terms of use
Study contacts
-
Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
-
ARNAS Garibaldi - Catania
NOT_YET_RECRUITINGCatania, Italy
Contact
Contact
-
CH Bayonne
NOT_YET_RECRUITINGBayonne, France
Contact
Contact
-
CHP Brest - Pasteur
NOT_YET_RECRUITINGBrest, France
Contact
Contact
-
CHP Saint Gregoire
NOT_YET_RECRUITINGSaint-Grégoire, France
Contact
Contact
-
CHU Nîmes
NOT_YET_RECRUITINGNîmes, France
Contact
Contact
-
CHU Poitiers
NOT_YET_RECRUITINGPoitiers, France
Contact
Contact
-
CHU de Rennes
NOT_YET_RECRUITINGRennes, France
Contact
Contact
-
Centre De Cancérologie Du Grand Montpellier
NOT_YET_RECRUITINGMontpellier, France
Contact
Contact
-
Facharztzentrum für Urologie, Uro-Onkologie
NOT_YET_RECRUITINGBerlin, Germany
Contact
Contact
-
Fundación Instituto Valenciano de Oncología
NOT_YET_RECRUITINGValencia, Valencia, Spain
Contact
Contact
-
GHBS - Hôpital du Scorff
NOT_YET_RECRUITINGLorient, France
Contact
Contact
-
GHM Cancérologie - Institut Daniel Hollard
NOT_YET_RECRUITINGGrenoble, France
Contact
Contact
-
Hospices Civils de Lyon - HCL
NOT_YET_RECRUITINGParis, France
Contact
Contact
-
Hospital Clinico Universitario de Valencia
NOT_YET_RECRUITINGValencia, Valencia, Spain
Contact
Contact
-
Hospital Clínic de Barcelona
NOT_YET_RECRUITINGBarcelona, Barcelona, Spain
Contact
Contact
-
Hospital Clínico Universitario Santiago de Compostela
NOT_YET_RECRUITINGSantiago de Compostela, La Coruña, Spain
Contact
Contact
-
Hospital Clínico Universitario de Valladolid
NOT_YET_RECRUITINGValladolid, Valladolid, Spain
Contact
Contact
-
Hospital General Universitario Morales Meseguer
NOT_YET_RECRUITINGMurcia, Murcia, Spain
Contact
Contact
-
Hospital General Universitario de Valencia
NOT_YET_RECRUITINGValencia, Valencia, Spain
Contact
Contact
-
Hospital Riuniti di Foggia - Foggia
NOT_YET_RECRUITINGFoggia, Italy
Contact
Contact
-
Hospital Santa Creu i Sant Pau
NOT_YET_RECRUITINGBarcelona, Barcelona, Spain
Contact
Contact
-
Hospital Universitari Vall d´Hebron
NOT_YET_RECRUITINGBarcelona, Bacelona, Spain
Contact
Contact
-
Hospital Universitario 12 Octubre
RECRUITINGMadrid, Madrid, Spain
Contact
Contact
-
Hospital Universitario Clínico San Carlos
NOT_YET_RECRUITINGMadrid, Madrid, Spain
Contact
Contact
-
Hospital Universitario La Paz
NOT_YET_RECRUITINGMadrid, Madrid, Spain
Contact
Contact
-
Hospital Universitario Marques de Valdecilla
NOT_YET_RECRUITINGSantander, Cantabria, Spain
Contact
Contact
-
Hospital Universitario Miguel Servet
NOT_YET_RECRUITINGZaragoza, Aragon, Spain
Contact
Contact
-
Hospital Universitario Ramón y Cajal
NOT_YET_RECRUITINGMadrid, Madrid, Spain
Contact
Contact
-
Hospital Universitario Virgen Macarena
NOT_YET_RECRUITINGSeville, Sevilla, Spain
Contact
Contact
-
Hospital Universitario Virgen de la Victoria
NOT_YET_RECRUITINGMálaga, Málaga, Spain
Contact
Contact
-
Hospital Universitario Virgen de las Nieves
NOT_YET_RECRUITINGGranada, Granada, Spain
Contact
Contact
-
Hospital del Mar
NOT_YET_RECRUITINGBarcelona, Barcelona, Spain
Contact
Contact
-
Hôpital Européen Georges Pompidou
NOT_YET_RECRUITINGParis, France
Contact
Contact
-
Hôpital Foch
NOT_YET_RECRUITINGSuresnes, France
Contact
Contact
-
Hôpital Franco-Britannique
NOT_YET_RECRUITINGLevallois-Perret, France
Contact
Contact
-
Hôpital Henri-Mondor
NOT_YET_RECRUITINGCréteil, France
Contact
Contact
-
Hôpital Paris Saint-Joseph
NOT_YET_RECRUITINGParis, France
Contact
Contact
-
Hôpital Pitié-Salpêtrière
NOT_YET_RECRUITINGParis, France
Contact
Contact
-
ICO Badalona
NOT_YET_RECRUITINGBarcelona, Barcelona, Spain
Contact
Contact
-
Institut Bergonié
NOT_YET_RECRUITINGBordeaux, France
Contact
Contact
-
Institut Català d'Oncologia (ICO) L´Hospitalet de Llobregat
NOT_YET_RECRUITINGL'Hospitalet de Llobregat, Barcelona, Spain
Contact
Contact
-
Institut Godinot
NOT_YET_RECRUITINGReims, France
Contact
Contact
-
Institut du Cancer de Montpellier - Val d'Aurelle (ICM)
NOT_YET_RECRUITINGMontpellier, France
Contact
Contact
-
Johanniter-Krankenhaus Bonn-Gronau
NOT_YET_RECRUITINGBonn, Germany
Contact
Contact
-
Klinikum Recklinghausen
NOT_YET_RECRUITINGRecklinghausen, Germany
Contact
Contact
-
National Instute of Oncology - Milan
NOT_YET_RECRUITINGMilan, Italy
Contact
Contact
-
Policlinico Gemelli Hospital - Rome
NOT_YET_RECRUITINGRoma, Italy
Contact
Contact
-
Policlinico Umberto I - Rome
NOT_YET_RECRUITINGRoma, Italy
Contact
Contact
-
Polyclinique Saint Georges
NOT_YET_RECRUITINGSaint-Georges-de-Didonne, France
Contact
Contact
-
Praxis Berlin / FASANUS - Urologie - Andrologie - Uro-Onkologie
NOT_YET_RECRUITINGBerlin, Germany
Contact
Contact
-
SRH Wald-Klinikum Gera
NOT_YET_RECRUITINGGera, Germany
Contact
Contact
-
ULS Alto Ave
NOT_YET_RECRUITINGGuimarães, Portugal
Contact
Contact
-
University Hospital Göttingen
NOT_YET_RECRUITINGGöttingen, Germany
Contact
Contact
-
University Hospital Rostock
NOT_YET_RECRUITINGRostock, Germany
Contact
Contact
-
Urologicum Karlsruhe MVZ
NOT_YET_RECRUITINGKarlsruhe, Germany
Contact
Contact
-
Urologische Facharztpraxis Saale
NOT_YET_RECRUITINGHalle, Germany
Contact
Contact