Cancer pill shows promise against tough brain tumor
NCT ID NCT06275919
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This phase 2 trial tests whether the drug regorafenib can slow tumor growth in people with recurrent meningioma, a type of brain tumor. About 104 participants will receive either regorafenib or standard care. The main goal is to see how long the tumor stays under control.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Regorafenib (a targeted cancer drug taken as a daily pill)
- What this could lead to
- If it works, this could provide a new treatment option to slow tumor growth and extend life for people with recurrent meningioma.
- What could go wrong
- This is a mid-stage trial with only 104 participants, so results may not apply to everyone. Regorafenib can cause side effects like fatigue, hand-foot skin reactions, and liver issues.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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A.O.U. Città della Salute e della Scienza di Torino
RECRUITINGTorino, Italy
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A.O.U. Policlinico di Bari
RECRUITINGBari, Italy
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Azienda Ospedaliera Universitaria Gaetano Martino
RECRUITINGMessina, Italia/Messina, 98124, Italy
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Azienda Ospedaliero Universitaria Careggi
RECRUITINGFlorence, Italy
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Fondazione IRCCS Istituto Neurologico Carlo Besta
RECRUITINGMilan, Italy
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Fondazione Policlinico Universitario Agostino Gemelli IRCCS
RECRUITINGRoma, Italy
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Humanitas Cancer Center
RECRUITINGRozzano, Milano, Italy
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IRCCS Istituto Tumori Regina Elena
RECRUITINGRoma, Italy
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IRCCS Ospedale San Raffaele
RECRUITINGMilan, Italy
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IRST Istituto Romagnolo per lo Studio dei Tumori "Dino Amadori"
RECRUITINGMeldola, Forlì-Cesena, Italy
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Istituto Oncologico Veneto
RECRUITINGPadova, 35128, Italy
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Ospedale Bellaria - AUSL Bologna
RECRUITINGBologna, Italy
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Ospedale San Paolo
COMPLETEDBari, Italy
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Ospedale del Mare
RECRUITINGNaples, Italy
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Policlinico San Martino
RECRUITINGGenova, Italy
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Policlinico Umberto I - Università Sapienza Roma
NOT_YET_RECRUITINGRoma, Italy
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Spedali Riuniti
RECRUITINGLivorno, Italy
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