New drug aims to tackle iron overload in thalassemia patients
NCT ID NCT06421636
First seen Jun 27, 2026 · Last updated Jul 02, 2026 · Updated 2 times
Summary
This Phase 2 trial tests an experimental drug called REGN7999 in about 95 people with non-transfusion dependent beta-thalassemia who have too much iron in their bodies. The drug is given as a shot under the skin and aims to safely reduce iron levels in the liver. Researchers will compare it to a placebo to see if it works and what side effects occur.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- REGN7999 (a drug that blocks TMPRSS6 to help control iron levels)
- What this could lead to
- If it works, this could offer a new way to manage iron overload in people with beta-thalassemia who don't need regular blood transfusions.
- What could go wrong
- This is an early Phase 2 study with only 95 participants, so results may not apply to everyone. The drug may cause side effects or fail to lower iron enough.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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All India Institute of Medical Sciences, New Delhi
New Delhi, National Capital Territory of Delhi, 110029, India
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Amrita Institute of Medical Sciences and Research Centre (AIMS)
Kochi, Kerala, 682041, India
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Chiang Mai University
Chiang Mai, 50200, Thailand
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Children's Hospital Agia Sophia
Athens, Attica, 11521, Greece
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Chulalongkorn University
Bangkok, 10330, Thailand
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Day Hospital Thalassemia and Haemoglobinopathies (DHTE); A.O.U S.Anna
Ferrara, 44124, Italy
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Hacettepe University
Ankara, 06100, Turkey (Türkiye)
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Hemato-Oncology Clinic Ahmedabad PVT. LTD.
Ahmedabad, Gujarat, 380009, India
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Hospital Ampang
Ampang, Selangor, 68000, Malaysia
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Hospital Queen Elizabeth
Kota Kinabalu, Sabah, 88586, Malaysia
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Hospital Tunku Ampuan Besar Tuanku Aishah Rohani (HPKK UKM)
Kuala Lumpur, 56000, Malaysia
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Imperial College Healthcare NHS Trust
London, W12 0HS, United Kingdom
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Indraprastha Apollo Hospitals
New Delhi, National Capital Territory of Delhi, 110048, India
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JK Lon Hospital
Jaipur, Rajasthan, 302004, India
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K Eristavi National Center of Experimental and Clinical Surgery
Tbilisi, 0159, Georgia
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K J Somaiya Super Specialty Hospital & Research Centre
Mumbai, Maharashtra, 400022, India
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Laiko General Hospital of Athens
Athens, Attica, 11527, Greece
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Medinvest Institute of Hematology and Transfusiology Limited
Tbilisi, 0160, Georgia
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Nirmal Hospital Pvt. Ltd - Surat
Surat, Gujarat, 395002, India
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Phramongkutklao Hospital
Bangkok, 10400, Thailand
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Sarawak General Hospital
Kuching, Sarawak, 93586, Malaysia
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Songklanagarind Hospital, Prince of Songkla University
Hat Yai, Changwat Songkhla, 90110, Thailand
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Srinagarind Hospital
Khon Kaen, 40000, Thailand
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University College London Hospitals NHS Trust
London, NW1 2PG, United Kingdom
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University Hospital of Ioannina
Ioannina, 45110, Greece
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Weill Cornell Medicine
New York, New York, 10065, United States