Can a lower radiation dose still beat nasopharyngeal cancer?

NCT ID NCT07789158

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

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Status unknown
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First seen Aug 27, 2026 · Last updated Aug 28, 2026 · Updated 1 time

Summary

This trial tests whether people with early-stage nasopharyngeal cancer who respond well to induction chemotherapy can safely receive a lower dose of radiation than the standard. Participants whose tumors shrink significantly and whose EBV-DNA drops to zero after chemo are randomly assigned to either reduced-dose or standard-dose radiation. The goal is to see if the reduced dose keeps the cancer from returning in the head and neck area while potentially causing fewer side effects.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Reduced-dose intensity-modulated radiation therapy (IMRT) after induction chemotherapy
What this could lead to
If successful, this could allow some patients with early-stage nasopharyngeal cancer to receive less radiation, reducing long-term side effects while maintaining cancer control.
What could go wrong
The trial is early (phase II) and not yet conclusive. Lower radiation might not control the cancer as well as standard doses, and the results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

About 269 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Sep 2026

An estimate. Start dates often move.

Expected to finish

Aug 2031

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age: 18 - 65 years old. * Pathologically confirmed nasopharyngeal carcinoma, WHO type II or III non-keratinizing cancer. * AJCC/UICC 9th edition stage IB-II untreated non-metastatic nasopharyngeal carcinoma (T3 requires no extensive cranial base invasion and the invasion volume should be \< 22 mL; N1-2 requires baseline lymph nodes \< 4 cm). * Before treatment, plasma EBV-DNA needs to be tested and dynamic monitoring of EBV-DNA can be completed. * ECOG performance status 0 - 1 points. * Main organ functions meet the following requirements: neutrophils ≥ 1.5 × 10\^9/L, platelets ≥ 100 × 10\^9/L, hemoglobin ≥ 90 g/L; ALT/AST ≤ 2.5 × ULN, total bilirubin ≤ 1.5 × ULN; creatinine clearance rate ≥ 60 mL/min. * Sign a written informed consent form and be willing to complete the treatment, follow-up and quality of life assessment according to the protocol. Exclusion Criteria: * Metastasis to T4, N3 or distant sites; AJCC/UICC 9th edition stage III-IV. * Had received chemotherapy, targeted therapy, or immunotherapy before the diagnosis of nasopharyngeal carcinoma, and had a history of radiotherapy or surgery for head and neck tumors (except for diagnostic biopsies). * Pregnant or lactating; non-pregnant and non-lactating subjects who do not agree to take effective contraceptive measures. * Had severe and uncontrollable heart, lung, liver, kidney, neurological or mental diseases, and the investigator judged that they were not suitable for radical treatment or affected compliance. * Had a history of other malignant tumors within the past 5 years, except for the following situations: cured localized tumors, such as skin basal cell carcinoma, skin squamous cell carcinoma, superficial bladder cancer, prostate carcinoma in situ, cervical carcinoma in situ, breast carcinoma in situ, papillary thyroid carcinoma, etc. * Could not complete the imaging examinations, EBV-DNA tests, follow-up or quality of life assessment as required by the protocol.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

How to take part

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  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

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  3. A doctor treating you

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Contacts and locations

Locations

  • Fudan Universtiy Shanghai Cancer Center

    Shanghai, Shanghai Municipality, 200032, China

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