Can a lower radiation dose still beat nasopharyngeal cancer?
NCT ID NCT07789158
First seen Aug 27, 2026 · Last updated Aug 28, 2026 · Updated 1 time
Summary
This trial tests whether people with early-stage nasopharyngeal cancer who respond well to induction chemotherapy can safely receive a lower dose of radiation than the standard. Participants whose tumors shrink significantly and whose EBV-DNA drops to zero after chemo are randomly assigned to either reduced-dose or standard-dose radiation. The goal is to see if the reduced dose keeps the cancer from returning in the head and neck area while potentially causing fewer side effects.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Reduced-dose intensity-modulated radiation therapy (IMRT) after induction chemotherapy
- What this could lead to
- If successful, this could allow some patients with early-stage nasopharyngeal cancer to receive less radiation, reducing long-term side effects while maintaining cancer control.
- What could go wrong
- The trial is early (phase II) and not yet conclusive. Lower radiation might not control the cancer as well as standard doses, and the results may not apply to all patients.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 2
Tests whether the treatment actually works, and watches for side effects, in a larger group.
- Participants
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About 269 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Sep 2026
An estimate. Start dates often move.
- Expected to finish
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Aug 2031
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 65 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Age: 18 - 65 years old. * Pathologically confirmed nasopharyngeal carcinoma, WHO type II or III non-keratinizing cancer. * AJCC/UICC 9th edition stage IB-II untreated non-metastatic nasopharyngeal carcinoma (T3 requires no extensive cranial base invasion and the invasion volume should be \< 22 mL; N1-2 requires baseline lymph nodes \< 4 cm). * Before treatment, plasma EBV-DNA needs to be tested and dynamic monitoring of EBV-DNA can be completed. * ECOG performance status 0 - 1 points. * Main organ functions meet the following requirements: neutrophils ≥ 1.5 × 10\^9/L, platelets ≥ 100 × 10\^9/L, hemoglobin ≥ 90 g/L; ALT/AST ≤ 2.5 × ULN, total bilirubin ≤ 1.5 × ULN; creatinine clearance rate ≥ 60 mL/min. * Sign a written informed consent form and be willing to complete the treatment, follow-up and quality of life assessment according to the protocol. Exclusion Criteria: * Metastasis to T4, N3 or distant sites; AJCC/UICC 9th edition stage III-IV. * Had received chemotherapy, targeted therapy, or immunotherapy before the diagnosis of nasopharyngeal carcinoma, and had a history of radiotherapy or surgery for head and neck tumors (except for diagnostic biopsies). * Pregnant or lactating; non-pregnant and non-lactating subjects who do not agree to take effective contraceptive measures. * Had severe and uncontrollable heart, lung, liver, kidney, neurological or mental diseases, and the investigator judged that they were not suitable for radical treatment or affected compliance. * Had a history of other malignant tumors within the past 5 years, except for the following situations: cured localized tumors, such as skin basal cell carcinoma, skin squamous cell carcinoma, superficial bladder cancer, prostate carcinoma in situ, cervical carcinoma in situ, breast carcinoma in situ, papillary thyroid carcinoma, etc. * Could not complete the imaging examinations, EBV-DNA tests, follow-up or quality of life assessment as required by the protocol.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Fudan Universtiy Shanghai Cancer Center
Shanghai, Shanghai Municipality, 200032, China
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- Could avoiding Pre-Radiation tooth removal protect jaw health?