New combo therapy aims to shrink tumors, spare patients from surgery

NCT ID NCT07381777

Summary

This study is testing whether adding an immunotherapy drug (dostarlimab) to standard chemotherapy (XELOX) after chemoradiation works better than chemotherapy alone for patients with a specific type of locally advanced rectal cancer. The goal is to better control the cancer and see if more patients can achieve a complete response, potentially avoiding major surgery to remove the rectum. About 270 patients will be randomly assigned to receive the combination or chemotherapy alone.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • A.O. Oncologia S. Croce e Carle - presidio Ospedaliero A. Carle

    Cuneo, Italy

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  • AOU di Modena - Policlinico di Modena - DH Oncologico

    Modena, Italy

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  • AOUC Azienda Ospedaliero - Universitaria Careggi Oncologia Medica

    Florence, Italy

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  • ASST Brianza

    Vimercate, Italy

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  • Fondazione Policlinico Universitario Campus Bio-Medico

    Roma, Italy

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  • IRCCS - Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori"

    Meldola (FC), Italy

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  • IRCCS Istituto clinico humanitas

    Rozzano, Italy

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  • Oncologia Clinica Sperimentale Addome Istituto Nazionale Tumori - IRCCS Fondazione G. Pascale

    Naples, Italy

    Contact Phone: •••-•••-•••• Email: •••••@•••••

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  • Oncologia Falck - ASST Grande Ospedale Metropolitano Niguarda

    Milan, Italy

    Contact Phone: •••-•••-•••• Email: •••••@•••••

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  • Oncologia Medica - Policlinico Universitario Gemelli IRCCS

    Roma, Italy

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  • Oncologia Medica 1, A.O.U. Città della Salute e della Scienza di Torino Ospedale Molinette

    Torino, Italy

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  • Oncologia Medica 2 Universitaria

    Pisa, Italy

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  • Oncologia Medica Fondazione Poliambulanza Istituto Ospedaliero

    Brescia, Italy

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  • Oncologia Ricerca Clinica - IRCCS Casa Sollievo della Sofferenza

    San Giovanni Rotondo, Italy

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  • Oncologia medica e prevenzione oncologica - Centro di Riferimento Oncologico

    Aviano, Italy

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  • Ospedale San Donato - UOC Oncologia Medica dell'Aretino, Casentino, Valtiberina, Valdichiana Aretina

    Arezzo, Italy

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  • S.C. Oncologia Medica, Ospedale Felettino

    La Spezia, Italy

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  • SC Oncologia, Fondazione IRCCS Policlinico S. Matteo

    Pavia, Italy

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  • SOC Oncologia Azienda sanitaria Universitaria Friuli Centrale - P.O. S. Maria della Misericordia

    Udine, Italy

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  • SOC di Oncologia Provinciale, AUSL IRCCS di Reggio Emilia

    Reggio Emilia, Italy

    Contact Phone: •••-•••-•••• Email: •••••@•••••

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  • Struttura Complessa Oncologia Medica 1 - Fondazione IRCCS Istituto Nazionale dei Tumori

    Milan, Italy

    Contact Phone: •••-•••-•••• Email: •••••@•••••

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  • U.O. C. di Oncologia Medica - OSPEDALE CIVILE SS ANNUNZIATA

    Sassari, Italy

    Contact Phone: •••-•••-•••• Email: •••••@•••••

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  • U.O. Oncologia Medica 1 IRCCS Ospedale Policlinico San Martino

    Genova, Italy

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  • UOC Di Oncologia Medica AOU Federico II

    Naples, Italy

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  • UOC Oncoematologia AOU Vanvitelli

    Naples, Italy

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  • UOC Oncologia 1 - Ospedale Busonera - IRCCS Istituto Oncologico Veneto

    Padua, Italy

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  • UOC Oncologia Medica - ARNAS Garibaldi PO Nesima

    Catania, Italy

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  • UOC Oncologia Medica Azienda Ospedaliero Universitaria di Parma

    Parma, Italy

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  • UOC Oncologia Medica IRCCS Azienda Ospedaliero-Universitaria di Bologna

    Bologna, Italy

    Contact Phone: •••-•••-•••• Email: •••••@•••••

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  • UOC Oncologia Ravenna Dipartimento di Oncologia ed Ematologia - AUSL Romagna

    Ravenna, Italy

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

Conditions

Explore the condition pages connected to this study.