New combo therapy aims to shrink rectal tumors before surgery
NCT ID NCT06911684
First seen May 02, 2026 · Last updated May 13, 2026 · Updated 1 time
Summary
This study tests whether a short course of radiation combined with immunotherapy (iparomlimab and tuvonralimab), a targeted drug (regorafenib), and chemotherapy (CAPOX) can shrink advanced rectal cancer before surgery. About 88 adults with a specific type of rectal cancer will be randomly assigned to one of two treatment schedules. The goal is to see if this approach leads to a complete response, meaning no cancer remains after treatment.
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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Dept. of Colorectal Surgery, Sun Yat-sen University Cancer Center. Yuexiu District, Dongfeng East Road 651
RECRUITINGGuangzhou, Guangdong, 510060, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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