New drug cocktail shows promise against tough rectal cancers

NCT ID NCT06933251

First seen Mar 13, 2026 · Last updated May 13, 2026 · Updated 11 times

Summary

This study tests whether adding two immune-boosting drugs (PCSK9 and PD-1 inhibitors) to standard chemoradiation can help shrink or eliminate locally advanced rectal cancer. It involves 30 adults aged 18-75 with a specific type of rectal cancer (pMMR/MSS) that has not spread. The goal is to see if this combination improves complete response rates and organ preservation.

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Contacts and locations

Locations

  • Guangdong Provincial People's Hospital

    Guangzhou, Guangdong, 510080, China

  • No. 106, Zhongshan 2nd Road, Yuexiu District, Guangzhou

    Guangzhou, Guangdong, China

Conditions

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