Lung cancer drug amivantamab under Real-World microscope

NCT ID NCT07230691

Recruiting now Knowledge-focused Sponsor: Janssen Research & Development, LLC Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jul 31, 2026 · Updated 4 times

Summary

This study is observing 380 people with a common type of advanced lung cancer caused by EGFR mutations who are receiving amivantamab as part of their routine care. Researchers will track how long patients stay on treatment and how well it controls the cancer in everyday medical practice. The goal is to understand real-world outcomes, not to test a new drug.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: amivantamab
What this could lead to: If successful, this study could provide real-world evidence on how well amivantamab works for advanced EGFR-mutated lung cancer outside of clinical trials.
What could go wrong: This is an observational study, not a controlled trial, so results may be influenced by patient selection and real-world variability. It does not test a new treatment or guarantee improved outcomes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

non-small cell lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CARCINOMA, NON-SMALL-CELL LUNG

Contacts and locations

Locations

A.O.R Villa Sofia Cervello
RECRUITING

Palermo, 90146, Italy
ASL Gallura - Ospedale Giovanni Paolo II
RECRUITING

Olbia, 07026, Italy
ASST Grande Ospedale Metropolitano Niguarda
RECRUITING

Milan, 20162, Italy
ASST Papa Giovanni XXIII Bergamo
RECRUITING

Bergamo, 24127, Italy
ASST Spedali Civili Brescia
RECRUITING

Brescia, 25123, Italy
Aou San Luigi Gonzaga
RECRUITING

Orbassano, 10043, Italy
Assuta MC
RECRUITING

Tel Aviv, 6971028, Israel
Augusta Kliniken Bochum Hattingen
RECRUITING

Bochum, 44791, Germany
Az Groeninge
RECRUITING

Kortrijk, 8500, Belgium
Azienda Ospedaliera ''Vito Fazzi''
RECRUITING

Lecce, 73100, Italy
Azienda Ospedaliera Pugliese Ciaccio Catanzaro
RECRUITING

Catanzaro, 88100, Italy
Azienda Ospedaliero Universitaria Maggiore della Carita di Novara
RECRUITING

Novara, 28100, Italy
Azienda Ospedaliero Universitaria Policlinico Paolo Giaccone
RECRUITING

Palermo, 90127, Italy
Azienda Ospedaliero Universitaria di Sassari
RECRUITING

Sassari, 07100, Italy
Azienda Ospedaliero-Universitaria Di Parma
RECRUITING

Parma, 43126, Italy
Azienda Sanitaria Territoriale Pesaro Urbino
RECRUITING

Urbino, 61121, Italy
Bundeswehrkrankenhaus Ulm
RECRUITING

Ulm, 89081, Germany
CHU de Liege
RECRUITING

Liège, 4000, Belgium
Campus Bio Medico di Roma
RECRUITING

Roma, 128, Italy
Chu Helora Hospital La Louviere Site Jolimont
RECRUITING

La Louvière, 7100, Belgium
Complexo Hosp. Univ. de Ourense
RECRUITING

Ourense, 32005, Spain
Eastbourne District General Hospital
RECRUITING

Eastbourne, BN21 2UD, United Kingdom
European Institute of Oncology
RECRUITING

Milan, 20141, Italy
Evangelisches Klinikum Bethel
RECRUITING

Bielefeld, 33611, Germany
Facharztzentrum Eppendorf
RECRUITING

Hamburg, 20249, Germany
Fakultni Thomayerova nemocnice
RECRUITING

Prague, 140 59, Czechia
Fakultni nemocnice Brno
RECRUITING

Brno, 625 00, Czechia
Fakultni nemocnice Hradec Kralove
RECRUITING

Hradec Králové, 500 05, Czechia
Fakultni nemocnice Olomouc
RECRUITING

Olomouc, 77900, Czechia
Fondazione G Pascale Istituto Nazionale Tumori IRCCS
RECRUITING

Naples, 80131, Italy
Fondazione Policlinico Universitario A Gemelli IRCCS
RECRUITING

Roma, 00168, Italy
Haematologie u Onkologie Koeln MV Zentrum
RECRUITING

Cologne, 50677, Germany
Hosp Regional Univ de Malaga
RECRUITING

Málaga, 29011, Spain
Hosp Reina Sofia
RECRUITING

Córdoba, 14004, Spain
Hosp. Clinico Univ. de Santiago
RECRUITING

Santiago de Compostela, 15706, Spain
Hosp. Clinico Univ. de Valladolid
RECRUITING

Valladolid, 47003, Spain
Hosp. Univ. Lucus Augusti
RECRUITING

Lugo, 27003, Spain
Hosp. Univ. Son Espases
RECRUITING

Palma de Mallorca, 07120, Spain
Hosp. de Jerez de La Frontera
RECRUITING

Jerez de la Frontera, 11407, Spain
Hospital Bethanien Solingen
RECRUITING

Solingen, 42699, Germany
Hospital Universitario Virgen Rocio
RECRUITING

Seville, 41013, Spain
Istituto Dei Tumori Di Milano
RECRUITING

Milan, 20133, Italy
Istituto Nazionale Tumori Regina Elena
RECRUITING

Rome, 00144, Italy
Istituto di Candiolo, IRCCS
RECRUITING

Candiolo, 10060, Italy
Jessa Ziekenhuis
RECRUITING

Hasselt, 3500, Belgium
Kliniken Essen-Mitte; Evangelische Huyssens-Stiftung
RECRUITING

Essen, 45136, Germany
Kliniken der Stadt Köln gGmbH, Krankenhaus Köln-Mehrheim
RECRUITING

Cologne, 51109, Germany
Klinikum Chemnitz gGmbH
RECRUITING

Chemnitz, 09113, Germany
Klinikum Klagenfurt am Worthersee
RECRUITING

Klagenfurt, 9020, Austria
Klinikum Konstanz
RECRUITING

Konstanz, 78464, Germany
Klinikum Region Hannover Klinikum Siloah
RECRUITING

Hanover, 30449, Germany
Knappschaft Kliniken MVZ Nord GmbH
RECRUITING

Recklinghausen, 45659, Germany
LA Regio Kliniken Klinik Landshut Mitte
RECRUITING

Landshut, 84034, Germany
Landeskrankenhaus Hochzirl Natters
RECRUITING

Natters, 6161, Austria
Lungenklinik Hemer
RECRUITING

Hemer, 58675, Germany
MVZ Onkologie Groschek Keller
RECRUITING

Stolberg, 52222, Germany
MVZ am Klinikum Aschaffenburg Onkologie
RECRUITING

Aschaffenburg, 63739, Germany
MVZ fur Hamatologie und Onkologie Rhein Kreis GmbH
RECRUITING

Neuss, 41462, Germany
New Cross Hospital
RECRUITING

Heath Town, WV10 0QP, United Kingdom
Oncologia Medica - Irccs - Istituto Tumori Giovanni Paolo II
RECRUITING

Bari, 70124, Italy
Onkologie am Raschplatz
RECRUITING

Hanover, 30161, Germany
Ospedale Policlinico San Martino IRCCS
RECRUITING

Genova, 16132, Italy
Ospedale San Giuseppe Moscati di Avellino
RECRUITING

Avellino, 83100, Italy
Ospedali Riuniti Di Ancona
RECRUITING

Torrette-Ancona, 60126, Italy
PO G.Rodolico, AOU Policlinico-Vittorio Emanuele Catania
RECRUITING

Catania, 95123, Italy
Rabin Medical Center
RECRUITING

Petah Tikva, 4941492, Israel
Royal Marsden Hospital
RECRUITING

London, SW3 6JJ, United Kingdom
Royal Marsden Hospital (Sutton)
RECRUITING

Sutton, SM2 5PT, United Kingdom
Royal Surrey County Hospital NHS Trust
RECRUITING

Guildford, GU2 7XX, United Kingdom
Royal United Hospital
RECRUITING

Bath, BA1 3NG, United Kingdom
San Gerardo Hospital
RECRUITING

Monza, 20900, Italy
San Raffaele Hospital
RECRUITING

Milan, 20132, Italy
Sheba Medical Center
RECRUITING

Ramat Gan, 5262000, Israel
The Christie NHS Foundation Trust Christie Hospital
RECRUITING

Manchester, M20 4BX, United Kingdom
UZ Antwerpen
RECRUITING

Edegem, 2650, Belgium
UZ Brussel
RECRUITING

Brussels, 1090, Belgium
Universitaetsklinikum Essen
RECRUITING

Essen, 45147, Germany
University Hospital Graz
RECRUITING

Graz, 8036, Austria
Velindre Hospital
RECRUITING

Cardiff, CF14 2TL, United Kingdom
Vitaz
RECRUITING

Sint-Niklaas, 9100, Belgium

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