New combo therapy aims to extend life in hard-to-treat head and neck cancer
NCT ID NCT07026474
First seen Jun 27, 2026 · Last updated Jul 24, 2026 · Updated 2 times
Summary
This phase 3 trial tests whether giving re-radiation with chemotherapy followed by the immunotherapy drug pembrolizumab can help people with recurrent head and neck cancer live longer compared to standard pembrolizumab alone or with chemotherapy. The study includes 214 adults whose cancer has returned locally and cannot be surgically removed. The main goal is to see if the new sequence improves survival at two years.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Gemeinschaftspraxis Hämatologie-Onkologie Dresden
RECRUITINGDresden, 01307, Germany
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Helios Klinikum Erfurt, Klinik für Strahlentherapie
RECRUITINGErfurt, 99089, Germany
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Klinikum Chemnitz gGmbH, Klinik für Radioonkologie
RECRUITINGChemnitz, 09116, Germany
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Klinikum Darmstadt GmbH, Institut für Radioonkologie und Strahlentherapie
RECRUITINGDarmstadt, 64283, Germany
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Klinikum St.-Elisabeth Straubing GmbH, Klinik für Hals-Nasen-Ohren-Heilkunde
RECRUITINGStraubing, 94315, Germany
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Klinikum Stuttgart, Klinik für Strahlentherapie und Radioonkologie
RECRUITINGStuttgart, 70174, Germany
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Marien Hospital Herne, Klinik für Strahlentherapie und Radio-Onkologie
RECRUITINGHerne, 44625, Germany
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Medizinische Hochschule Hannover (MHH), Klinik für Hämatologie, Hämostaseologie, Onkologie und Stammzelltransplantation
RECRUITINGHanover, 30625, Germany
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TUM Klinikum Rechts der Isar, Klinik und Poliklinik für RadioOnkologie und Strahlentherapie
NOT_YET_RECRUITINGMünchen, 81675, Germany
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UKGM Gießen, Klinik für Strahlentherapie
RECRUITINGGiessen, 35392, Germany
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Uniklinikum Erlangen, Strahlenklinik
RECRUITINGErlangen, 91054, Germany
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Universitätsklinikum Hamburg-Eppendorf, Zentrum für Onkologie; II. Medizinische Klinik und Poliklinik
RECRUITINGHamburg, 20246, Germany
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Universitätsklinikum Münster, Klinik für Strahlentherapie - Radioonkologie
RECRUITINGMünster, 48149, Germany
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Universitätsklinikum Regensburg, Klinik und Poliklinik für Strahlentherapie
RECRUITINGRegensburg, 93053, Germany
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Universitätsklinikum Tübingen, Klinik für Radioonkologie
RECRUITINGTübingen, 72076, Germany
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Universitätsklinikum Ulm, Klinik für Hals- Nasen-Ohrenheilkunde, Kopf- und Halschirurgie
RECRUITINGUlm, 89075, Germany
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Universitätsklinikum des Saarlandes, Klinik für Strahlentherapie und Radioonkologie
RECRUITINGHomburg, 66421, Germany
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Universitätsmedizin Frankfurt, Klinik für Strahlentherapie und Onkologie
RECRUITINGFrankfurt am Main, 60590, Germany
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Universitätsmedizin Rostock, Klinik und Poliklinik für Strahlentherapie / MVZ der Universitätsmedizin Rostock am Standort Südstadt gGmbH
NOT_YET_RECRUITINGRostock, 18059, Germany
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Universitätsmedizin der Johannes Gutenberg-Universität Mainz, Klinik und Poliklinik für Radioonkologie der Strahlentherapie
RECRUITINGMainz, 55131, Germany
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Universitätsspital Zürich, Klinik für Radio-Onkologie
NOT_YET_RECRUITINGZurich, 8091, Switzerland
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Sharper radiation boost aims to tackle head and neck cancers that return
- New combo attack: immunotherapy plus chemo before surgery for head and neck cancer
- New drug cocktail shows promise for tough head and neck cancers
- Remote hearing tests could save cancer Patients' hearing
- New drug cocktail aims to extend life in Tough-to-Treat head and neck cancer
- New combo therapy shows promise for Hard-to-Treat head and neck cancer