Inhaled mRNA therapy shows promise for rare lung disease
NCT ID NCT06633757
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This early-phase trial tested an inhaled mRNA therapy called RCT1100 in 14 adults with primary ciliary dyskinesia (PCD) caused by a specific genetic mutation (DNAI1). The goal was to see if the treatment could improve mucociliary clearance — the lungs' ability to clear mucus and germs. The study focused on safety and preliminary effectiveness to guide future research.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- RCT1100 (mRNA therapy inhaled via nebulizer)
- What this could lead to
- If successful, this could point toward a treatment that improves lung clearance and respiratory function in people with PCD caused by DNAI1 mutations.
- What could go wrong
- This is a very early Phase 1b trial with only 14 participants, so results may not apply to all PCD patients. The therapy is still experimental and safety or efficacy are not yet proven.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Copenhagen University Hospital - Rigshospitalet
Copenhagen, 2100, Denmark
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Münster University Hospital, Albert-Schweitzer-Campus 1
Münster, North Rhine-Westphalia, 48149, Germany
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UNC
Chapel Hill, North Carolina, 27514, United States
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