New drug shows promise in reducing NMOSD attacks

NCT ID NCT04201262

First seen Nov 01, 2025 · Last updated May 16, 2026 · Updated 23 times

Summary

This study tested a drug called ravulizumab in 58 adults with neuromyelitis optica spectrum disorder (NMOSD), a rare disease that causes inflammation in the nerves and spinal cord. The goal was to see if the drug could prevent or reduce relapses (sudden worsening of symptoms). Participants received ravulizumab and were compared to a placebo group from a previous study. The results help doctors understand if this treatment is safe and effective for controlling the disease.

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Contacts and locations

Locations

  • Research Site

    Aurora, Colorado, 80045, United States

  • Research Site

    Fort Collins, Colorado, 80528, United States

  • Research Site

    Washington D.C., District of Columbia, 20007, United States

  • Research Site

    Miami, Florida, 33136, United States

  • Research Site

    Boston, Massachusetts, 02114, United States

  • Research Site

    Rochester, Minnesota, 55905, United States

  • Research Site

    Jackson, Mississippi, 39216, United States

  • Research Site

    St Louis, Missouri, 63110, United States

  • Research Site

    Cincinnati, Ohio, 45219, United States

  • Research Site

    Houston, Texas, 77030, United States

  • Research Site

    Camperdown, 2050, Australia

  • Research Site

    Fitzroy, 3065, Australia

  • Research Site

    Vienna, 1090, Austria

  • Research Site

    Burnaby, British Columbia, V5G 2X6, Canada

  • Research Site

    Aarhus, 8200, Denmark

  • Research Site

    Strasbourg, 67098, France

  • Research Site

    Berlin, 10117, Germany

  • Research Site

    Leipzig, 04103, Germany

  • Research Site

    München, 81675, Germany

  • Research Site

    Cefalù, 90015, Italy

  • Research Site

    Gallarate, 21013, Italy

  • Research Site

    Naples, 80131, Italy

  • Research Site

    Roma, 00133, Italy

  • Research Site

    Rome, 00178, Italy

  • Research Site

    Chiba, 260-0877, Japan

  • Research Site

    Fukuoka, 812-8582, Japan

  • Research Site

    Kawagoe-shi, 350-8550, Japan

  • Research Site

    Niigata, 951-8585, Japan

  • Research Site

    Sendai, 980-8574, Japan

  • Research Site

    Sendai, 983-8512, Japan

  • Research Site

    Katowice, 40-571, Poland

  • Research Site

    Lódz, 90-324, Poland

  • Research Site

    Goyang-si, 10408, South Korea

  • Research Site

    Seoul, 02841, South Korea

  • Research Site

    Seoul, 03722, South Korea

  • Research Site

    Seoul, 06351, South Korea

  • Research Site

    Seoul, 143-729, South Korea

  • Research Site

    Barcelona, 08036, Spain

  • Research Site

    Madrid, 28040, Spain

  • Research Site

    Málaga, 29010, Spain

  • Research Site

    Oxford, OX3 9DU, United Kingdom

Conditions

Explore the condition pages connected to this study.