New drug radiprodil aims to tame seizures in rare brain disorders

NCT ID NCT06392009

First seen Apr 04, 2026 · Last updated May 23, 2026 · Updated 10 times

Summary

This study tests an experimental drug called radiprodil in 30 people with tuberous sclerosis complex (TSC) or focal cortical dysplasia (FCD) type II who have not responded to at least two seizure medications. The goal is to see if the drug is safe and can reduce seizures and behavioral symptoms. All participants receive the drug, and the study lasts up to one year.

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Contacts and locations

Locations

  • AOU Meyer

    Florence, Tuscany, 50139, Italy

  • Alberta Children's Hospital

    Calgary, T3A 2X6, Canada

  • Centrum Medyczne Plejady

    Krakow, 30363, Poland

  • Hospital Materno Infantil Sant Joan de Deu de Barcelona

    Barcelona, 08950, Spain

  • Hospital Ruber Internacional

    Madrid, 28034, Spain

  • Hospital Universitario Vall D´Hebrón

    Barcelona, 08035, Spain

  • Hospital Universitario Vithas La Milagrosa

    Madrid, 28010, Spain

  • IRCCS Istituto Giannina Gaslini

    Genoa, Liguria, 16146, Italy

  • Instytut Pomnik - Centrum Zdrowia Dziecka

    Warsaw, 04730, Poland

  • Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS)

    Roma, 00165, Italy

  • Queensland Children Hospital

    South Brisbane, 4101, Australia

  • The Hospital for Sick Children (Sick Kids)

    Toronto, M5G 1X8, Canada

  • UMC Uthrecht - Wilhelmina Kinderziekenhuis

    Utrecht, 3508, Netherlands

  • Universita Cattolica del Sacro Cuore - Policlinico Universitario "Agostino Gemelli"

    Roma, 00168, Italy

  • University Hospitals Bristol and Weston NHS Foundation Trust Bristol Royal Hospital for Children

    Bristol, BS2 8BJ, United Kingdom

  • University Hospitals Leuven, Pediatric Neurology

    Leuven, 3000, Belgium

  • Uniwersytecki Szpital Kliniczny w Poznaniu

    Poznan, 60356, Poland

  • Uniwersyteckie Centrum Kliniczne

    Gdansk, 80952, Poland

Conditions

Explore the condition pages connected to this study.