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Decoding DNA: can blood tests reveal who is most sensitive to radiation?

NCT ID NCT06253338

Knowledge-focused Sponsor: University Hospital, Essen Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Oct 20, 2026 · Last updated Oct 21, 2026 · Updated 1 time

Summary

Researchers are studying whether genomic changes in blood cells can show how a person's body responds to high-dose radiotherapy. The trial enrolls 30 adults with thoracic or head and neck cancer who have not yet received treatment. By analyzing DNA from blood and skin samples before and during radiotherapy, the team aims to identify patterns that might predict radiation sensitivity and repair capacity. The goal is to improve radiation protection by tailoring treatment to individual biology.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
genomic analysis of blood cells before and during radiotherapy
What this could lead to
If researchers can link genomic signatures to radiation response, doctors might one day tailor radiotherapy doses to each person's DNA repair capacity, reducing side effects and improving safety.
What could go wrong
This small observational study cannot prove that genomic signatures predict outcomes. The findings may not generalize beyond the specific cancer types and treatment regimens studied.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 30 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jun 2024

Expected to finish

Jan 2030

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: ECOG 0/1 no prior treatment no prior cancer diagnosis thoracic or head and neck cancer Exclusion Criteria: prior treatment (chemotherapy, radiotherapy, etc.) prior cancer diagnosis

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Conditions

The condition(s) this trial relates to.

cancer neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cancer DNA Radiation

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Department for Radiotherapy, University Hospital Essen, National Center for Tumor Diseases (NCT) West

    RECRUITING

    Essen, Germany / NRW, 45147, Germany

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