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New combo therapy aims to keep lymphoma in check longer

NCT ID NCT02390869

Ongoing Disease control Sponsor: Fondazione Italiana Linfomi - ETS Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This phase 3 trial tests whether adding lenalidomide to rituximab maintenance therapy works better than rituximab alone for people with relapsed follicular lymphoma who cannot have a stem cell transplant. About 128 participants will receive either the combination or rituximab alone after initial chemoimmunotherapy. The goal is to see if the combination delays cancer progression and is safe.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

follicular lymphoma Recurrence

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LYMPHOMA, FOLLICULAR

Contacts and locations

Locations

  • A O Papardo

    Messina, Italy

  • A.O. S. Maria di Terni

    Terni, TR, 05100, Italy

  • A.O. Universitaria Careggi Di Firenze

    Florence, 50139, Italy

  • A.O. Universitaria Citta' Della Salute E Della Scienza Di Torino

    Torino, 10126, Italy

  • A.O. Universitaria Ospedale Vittorio Emanuele E Ferrarotto Di Catania

    Catania, 95124, Italy

  • A.O. Universitaria Policlinico Di Modena

    Modena, 41124, Italy

  • A.O.U. Citta della Salute e della Scienza di Torino - Ematologia Universitaria

    Torino, Italy

  • A.S.L. 9 Opsedali Riuniti del Canavese

    Ivrea, Italy

  • AO Arcispedale S.Maria Nuova Ematologia

    Reggio Emilia, Italy

  • AO Santa Croce e Carle

    Cuneo, 12100, Italy

  • AOU La Sapienza

    Roma, 00161, Italy

  • AOU Maggiore della Carità di Novara

    Novara, 28100, Italy

  • ASST Grande Ospedale Metropolitano Niguarda

    Milan, MI, 20162, Italy

  • ASST Valle Olona - Ospedale di Circolo di Busto Arsizio

    Busto Arsizio, Varese, Italy

  • AUSL di Ravenna

    Ravenna, RA, 48100, Italy

  • Area Vasta Romagna e IRST

    Meldola (FC), Italy

  • Ausl Di Piacenza

    Piacenza, 29121, Italy

  • Centro di riferimento Oncologico - Oncologia Medica A

    Aviano (PN), Italy

  • Divisione di Ematologia Spedali Civili

    Brescia, Italy

  • Ematologia - OSPEDALE DI CIRCOLO E FONDAZIONE MACCHI

    Varese, 21100, Italy

  • Fondazione Del Piemonte Per L'Oncologia Ircc Di Candiolo

    Candiolo, Torino, 10060, Italy

  • Fondazione IRCCS Istituto Nazionale dei Tumori

    Milan, Italy

  • IRCCS Istituto Oncologico Veneto -Oncologia 1

    Padova, Italy

  • Nuovo Ospedale Civile di Sassuolo - Day Hospital Oncologico

    Sassuolo, Italy

  • Ospedale C. e G. Mazzoni UOS Ematologia

    Ascoli Piceno, Italy

  • Ospedale S. Giacomo di Castelfranco Veneto

    Castelfranco Veneto, Treviso, 31033, Italy

  • Ospedale SS Antonio Biagio e Cesare Arrigo

    Alessandria, Italy

  • SOS Ematologia Divisione Medicina Interna Ospedale degli Infermi

    Biella, Italy

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