Double-Drug maintenance shows promise for lymphoma patients

NCT ID NCT02390869

First seen Dec 08, 2025 · Last updated May 16, 2026 · Updated 24 times

Summary

This study is for people with a type of blood cancer called follicular lymphoma that has returned after treatment. It compares two maintenance therapies after initial chemo: one uses a single drug (rituximab), the other uses a combination of two drugs (rituximab and lenalidomide, called R2). The goal is to see if the combo keeps the cancer away longer and is safe. About 128 adults who cannot have a stem cell transplant are taking part.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • A O Papardo

    Messina, Italy

  • A.O. S. Maria di Terni

    Terni, TR, 05100, Italy

  • A.O. Universitaria Careggi Di Firenze

    Florence, 50139, Italy

  • A.O. Universitaria Citta' Della Salute E Della Scienza Di Torino

    Torino, 10126, Italy

  • A.O. Universitaria Ospedale Vittorio Emanuele E Ferrarotto Di Catania

    Catania, 95124, Italy

  • A.O. Universitaria Policlinico Di Modena

    Modena, 41124, Italy

  • A.O.U. Citta della Salute e della Scienza di Torino - Ematologia Universitaria

    Torino, Italy

  • A.S.L. 9 Opsedali Riuniti del Canavese

    Ivrea, Italy

  • AO Arcispedale S.Maria Nuova Ematologia

    Reggio Emilia, Italy

  • AO Santa Croce e Carle

    Cuneo, 12100, Italy

  • AOU La Sapienza

    Roma, 00161, Italy

  • AOU Maggiore della Carità di Novara

    Novara, 28100, Italy

  • ASST Grande Ospedale Metropolitano Niguarda

    Milan, MI, 20162, Italy

  • ASST Valle Olona - Ospedale di Circolo di Busto Arsizio

    Busto Arsizio, Varese, Italy

  • AUSL di Ravenna

    Ravenna, RA, 48100, Italy

  • Area Vasta Romagna e IRST

    Meldola (FC), Italy

  • Ausl Di Piacenza

    Piacenza, 29121, Italy

  • Centro di riferimento Oncologico - Oncologia Medica A

    Aviano (PN), Italy

  • Divisione di Ematologia Spedali Civili

    Brescia, Italy

  • Ematologia - OSPEDALE DI CIRCOLO E FONDAZIONE MACCHI

    Varese, 21100, Italy

  • Fondazione Del Piemonte Per L'Oncologia Ircc Di Candiolo

    Candiolo, Torino, 10060, Italy

  • Fondazione IRCCS Istituto Nazionale dei Tumori

    Milan, Italy

  • IRCCS Istituto Oncologico Veneto -Oncologia 1

    Padova, Italy

  • Nuovo Ospedale Civile di Sassuolo - Day Hospital Oncologico

    Sassuolo, Italy

  • Ospedale C. e G. Mazzoni UOS Ematologia

    Ascoli Piceno, Italy

  • Ospedale S. Giacomo di Castelfranco Veneto

    Castelfranco Veneto, Treviso, 31033, Italy

  • Ospedale SS Antonio Biagio e Cesare Arrigo

    Alessandria, Italy

  • SOS Ematologia Divisione Medicina Interna Ospedale degli Infermi

    Biella, Italy

Conditions

Explore the condition pages connected to this study.