New combo therapy targets hard-to-treat colorectal cancer in early trial

NCT ID NCT07229872

First seen Nov 17, 2025 · Last updated May 06, 2026 · Updated 28 times

Summary

This early-phase study tests a combination of two drugs—aipalirovorelizumab (QL1706) and fruquintinib—in 18 adults with a specific type of advanced colorectal cancer (pMMR/MSS) that has not responded to at least two prior treatments. The goal is to see if the combination can shrink tumors and how well patients tolerate it. Participants receive the drugs intravenously and orally in 3-week cycles until the cancer worsens or side effects become too severe.

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