New drug cocktail shows promise for Tough-to-Treat stomach cancer
NCT ID NCT06932068
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times
Summary
This phase 2 trial is testing whether a combination of two immunotherapy drugs (iparomlimab and tuvonralimab, together called QL1706) plus standard chemotherapy can help people with advanced HER2-negative stomach cancer that has low PD-L1 levels. The study will enroll 77 participants and measure how long the cancer stays under control, overall survival, and tumor shrinkage. It is currently recruiting.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Iparomlimab and tuvonralimab (QL1706) combined with chemotherapy (oxaliplatin and capecitabine)
What this could lead to
If successful, this could offer a new treatment option for people with advanced gastric cancer who have limited immunotherapy choices.
What could go wrong
This is a small, early-phase trial with no comparison group, so results may not be definitive. Side effects from the drug combination could be significant.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Locations
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Affiliated Hospital of Jining Medical College
RECRUITINGJining, Shandong, China
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Binzhou Medical University Hospital
RECRUITINGBinzhou, Shandong, China
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Dezhou People's Hospital
RECRUITINGDezhou, Shandong, China
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Jinan Central Hospital
RECRUITINGJinan, Shandong, China
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Jinan Third People's Hospital
RECRUITINGJinan, Shandong, China
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Jining First People's Hospital
RECRUITINGJining, China
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Liaocheng People's Hospital
RECRUITINGLiaocheng, Shandong, China
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Linyi Cancer Hospital
RECRUITINGLinyi, Shandong, China
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Linyi People's Hospital
RECRUITINGLinyi, Shandong, China
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Qilu Hospital of Shandong University
RECRUITINGJinan, Shandong, 250012, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Qilu Hospital of Shandong University(Qingdao)
RECRUITINGQingdao, Shandong, 250063, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Qingdao Municipal Hospital
RECRUITINGQingdao, Shandong, China
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Qingdao Municipal Hospital
RECRUITINGQingdao, Shandong, China
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Shandong Provincial Hospital Affiliated to Shandong First Medical University
RECRUITINGJinan, Shandong, 250012, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Shandong Provincial Third Hospital
RECRUITINGJinan, Shandong, 250012, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Shandong Qianfoshan Hospital
RECRUITINGJinan, Shandong, China
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Shengli Oilfield Central Hospital
RECRUITINGDongying, Shandong, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Taian City Central Hospital
RECRUITINGTai’an, Shandong, China
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Tengzhou Central People's Hospital
RECRUITINGTengzhou, Shandong, 277599, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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The Affiliated Hospital of Qingdao University
RECRUITINGQingdao, Shandong, China
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The First Affiliated Hospital of Zhengzhou University
RECRUITINGZhengzhou, Henan, 450052, China
Contact Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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The Second Affiliated Hospital of Shandong First Medical University
RECRUITINGTai’an, Shandong, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Weifang Hospital of Traditional Chinese Medicine
RECRUITINGWeifang, Shandong, China
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Weihai Central Hospital
RECRUITINGWeihai, Shandong, China
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Yantai Yuhuangding Hospital
RECRUITINGYantai, Shandong, China
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Yantai Yuhuangding Hospital
RECRUITINGYantai, Shandong, China
Contact Email: •••••@•••••
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Yantaishan Hospital
RECRUITINGYantai, Shandong, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Zibo Central Hospital
RECRUITINGZibo, Shandong, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Zibo First People's Hospital
RECRUITINGZibo, Shandong, China
Contact