Experimental combo therapy for advanced cancer shows promise but trial ends early

NCT ID NCT05846646

Terminated Disease control Sponsor: ImmuneSensor Therapeutics Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested a new treatment for people with non-small cell lung cancer or kidney cancer that had spread to up to six spots in the body. The treatment combined a special type of radiation therapy (PULSAR) with immunotherapy drugs (pembrolizumab or nivolumab), with or without an experimental drug called IMSA101 that boosts the immune system. The goal was to see if adding IMSA101 made the treatment safer and more effective. The trial was stopped early after enrolling only 6 participants, so results are limited.

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Conditions

The condition(s) this trial relates to.

non-small cell lung carcinoma renal cell carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OLIGOMETASTATIC DISEASE

Contacts and locations

Locations

Baylor College of Medicine Medical Center

Houston, Texas, 77030, United States
City of Hope Orange County Lennar Foundation Cancer Center

Irvine, California, 92618, United States
Huntsman Cancer Institute, University of Utah

Salt Lake City, Utah, 84112, United States
Laura & Isaac Perlmutter Cancer Center at NYU Langone Health

New York, New York, 10016, United States
Louis Stokes Cleveland VA Medical Center

Cleveland, Ohio, 44106, United States
MetroHealth Medical Center

Cleveland, Ohio, 44109, United States
Rutgers Cancer Institute of New Jersey

New Brunswick, New Jersey, 08903, United States
The University of Kansas Medical Center

Kansas City, Kansas, 66160, United States
University of Wisconsin Hospital and Clinics

Madison, Wisconsin, 53792, United States

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