New pill could ease psoriatic arthritis pain

NCT ID NCT06807424

Recruiting now Disease control Sponsor: Janssen Research & Development, LLC Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jul 31, 2026 · Updated 5 times

Summary

This study tests a new drug called icotrokinra (JNJ-77242113) for people with active psoriatic arthritis. About 750 adults who have tried other treatments will receive either the drug or a placebo. The goal is to see if the drug reduces joint pain and skin symptoms better than a placebo.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Icotrokinra (JNJ-77242113)
What this could lead to: If successful, icotrokinra could offer a new treatment option to reduce joint pain and skin symptoms in people with psoriatic arthritis.
What could go wrong: This is an early-stage Phase 3 trial, so results are not guaranteed. The drug may not work better than placebo, and side effects are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

psoriatic arthritis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ARTHRITIS, PSORIATIC

Contacts and locations

Locations

A O Universitaria Senese Ospedale Santa Maria alle Scotte
RECRUITING

Siena, 53100, Italy
A.O. Universitaria Ospedali Riuniti di Ancona
RECRUITING

Ancona, 60126, Italy
AARA Clinical Research
RECRUITING

Glendale, Arizona, 85306, United States
AARA Clinical Research 1
RECRUITING

Mesa, Arizona, 85210, United States
AARA Clinical Research Lone Star Arthritis and Rheumatology
RECRUITING

Irving, Texas, 75039, United States
ARCIS Salud SRL Aprillus asistencia e investigacion
RECRUITING

Buenos Aires, C1406AGA, Argentina
ASIMP Rheumatology Centre St Irina EOOD
RECRUITING

Sofia, 1750, Bulgaria
ASST Spedali Civili Brescia
RECRUITING

Brescia, 25123, Italy
Aarhus University Hospital
RECRUITING

Aarhus N, 8200, Denmark
Affiliated Hospital of Nantong University
RECRUITING

Nantong, 226001, China
Albuquerque Rehabilitation and Rheumatology
RECRUITING

Albuquerque, New Mexico, 87102, United States
All India Institute of Medical Sciences
RECRUITING

New Delhi, 110029, India
Alliance Clinical Trials
COMPLETED

Waterloo, Ontario, N2J 1C4, Canada
Altoona Center For Clinical Research
RECRUITING

Duncansville, Pennsylvania, 16635, United States
Ambulatorium sp. z o.o.
RECRUITING

Elblag, 82-300, Poland
Apollo Hospitals
RECRUITING

Bhubaneswar, 751005, India
Apollo Multispeciality Hospital Ltd
RECRUITING

Kolkata, 700054, India
Arsema
RECRUITING

Ciudad de Buenos Aires, C1431, Argentina
Arthritis and Rheumatism Associates ARA Jonesboro
RECRUITING

Jonesboro, Arkansas, 72401, United States
Arthritis and Rheumatology Research Institute
RECRUITING

Frisco, Texas, 75035, United States
Azienda Ospedaliero Universitaria Luigi Vanvitelli
RECRUITING

Naples, 80138, Italy
BR TRIALS Ensaios Clinicos e Consultoria Ltda
RECRUITING

São Paulo, 01236030, Brazil
Bacs Kiskun Varmegyei Oktatokorhaz
RECRUITING

Kecskemét, 6000, Hungary
Basingstoke And North Hampshire Hospital
RECRUITING

Basingstoke, RG24 9NA, United Kingdom
Beijing Tong Ren Hospital Capital Medical University
RECRUITING

Beijing, 100730, China
Bekes Varmegyei Kozponti Korhaz Pandy Kalman Tagkorhaz
RECRUITING

Gyula, 5700, Hungary
Betegapolo Irgalmas Rend Budai Irgalmasrendi Korhaz
RECRUITING

Budapest, 1023, Hungary
Betsi Cadwaladr University Health Board BCUHB
RECRUITING

Wrexham, LL13 7TD, United Kingdom
CCBR Clinical Research
RECRUITING

Bucharest, 030463, Romania
CCR Ostrava S R O
RECRUITING

Ostrava, 70200, Czechia
CEPIC Centro Paulista de Investigacao Clinica e Servicos Medicos
RECRUITING

São Paulo, 04266 010, Brazil
Center of Rheumatic Diseases
RECRUITING

Glendale, Wisconsin, 53217, United States
Centre de Recherche Musculo Squelettique
RECRUITING

Trois-Rivières, Quebec, G9A 3X2, Canada
Centro Medico Privado de Reumatologia Tucuman
RECRUITING

Ciudad de San Miguel de Tucuman, T4000AXL, Argentina
Centro Medico del Angel
RECRUITING

Mexicali, 45116, Mexico
Centro de Alta Especialidad en Reumatologia e Investigacion
RECRUITING

San Luis Potosí City, 78213, Mexico
Centro de Investigacion de Tratamientos Innovadores de Sinaloa
RECRUITING

Culiacán, 80000, Mexico
Centrul Medical Unirea
RECRUITING

Iași, 700259, Romania
Centrum Kliniczno Badawcze
RECRUITING

Elblag, 82-300, Poland
Centrum Medyczne All Med
RECRUITING

Krakow, 30-033, Poland
Centrum Medyczne Oporow
RECRUITING

Wroclaw, 52-416, Poland
Centrum Medyczne Pratia Gdynia
RECRUITING

Gdynia, 81-338, Poland
Centrum Medyczne Reuma Park
RECRUITING

Warsaw, 02-665, Poland
Charite - Campus Mitte
RECRUITING

Berlin, 10117, Germany
Chi Mei Medical Center
RECRUITING

Tainan, 710, Taiwan
Clinic of Robert Hozman
COMPLETED

Skokie, Illinois, 60076, United States
ClinicMed Daniluk Nowak Spolka Komandytowa
RECRUITING

Bialystok, 15-879, Poland
Clinical Research Philadelphia
RECRUITING

Philadelphia, Pennsylvania, 19114, United States
Clinical Research of West Florida
RECRUITING

Clearwater, Florida, 33765, United States
Clinical Research of West Florida 1
RECRUITING

Tampa, Florida, 33606, United States
Complex Rendelo Med Zrt
RECRUITING

Székesfehérvár, 8000, Hungary
DM Clinical Research
RECRUITING

Tomball, Texas, 77375, United States
DM Clinical Research 1
COMPLETED

Brookline, Massachusetts, 02446, United States
Debreceni Egyetem Reumatologiai Klinika
RECRUITING

Debrecen, 4032, Hungary
DermMedica Sp z o o
RECRUITING

Wroclaw, 51-503, Poland
Dermed Centrum Medyczne Sp z o o
RECRUITING

Lodz, 90-265, Poland
Diagnostic Consulting Center I Sliven
COMPLETED

Sliven, 8801, Bulgaria
Diagnostic-Consultative Center (DCC) Aleksandrovska
RECRUITING

Sofia, 1431, Bulgaria
Dokkyo Medical University Hospital
RECRUITING

Shimotsuga Gun, 321 0293, Japan
Dongguan People s Hospital
RECRUITING

Dongguan, 523109, China
Dr Sabeen Anwar Medicine Professional Corporation
RECRUITING

Windsor, Ontario, N8X 1T3, Canada
Eastern Regional Health Authority St Clares Mercy Hospital
RECRUITING

St. John's, Newfoundland and Labrador, A1C 5B8, Canada
Ecomed Research SRL
RECRUITING

Craiova, 200400, Romania
FN Motol
RECRUITING

Prague, 15000, Czechia
Fejer Varmegyei Szent Gyorgy Egyetemi Oktatokorhaz
RECRUITING

Székesfehérvár, 8000, Hungary
Fondazione Policlinico Universitario A Gemelli IRCCS
RECRUITING

Roma, 00168, Italy
Forth Valley Royal Hospital
RECRUITING

Larbert, FK5 4WR, United Kingdom
Fortis Hospital
RECRUITING

Noida, 201301, India
Frederiksberg Hospital
RECRUITING

Frederiksberg, 2000, Denmark
Fundacao Faculdade Regional De Medicina S Jose Rio Preto Hospital De Base
RECRUITING

São José do Rio Preto, 15090-000, Brazil
Gazi Universitesi Tip Fakultesi
RECRUITING

Ankara, 06570, Turkey (Türkiye)
Glasgow Royal Infirmary
RECRUITING

Glasgow, G31 2ER, United Kingdom
Grupo Clinico CATEI
RECRUITING

Guadalajara, 44630, Mexico
Gulhane Egitim ve Arastirma Hastanesi
RECRUITING

Ankara, 06010, Turkey (Türkiye)
Hamburger Rheuma Forschungszentrum II
RECRUITING

Hamburg, 20095, Germany
Haywood Hospital
RECRUITING

Staffordshire, ST6 7AG, United Kingdom
Hereford County Hospital
RECRUITING

Hereford, HR1 2ER, United Kingdom
Hiperdia Piata Sudului
RECRUITING

Bucharest, 041312, Romania
Hosp Regional Univ de Malaga
RECRUITING

Málaga, 29009, Spain
Hosp Reina Sofia
RECRUITING

Córdoba, 14004, Spain
Hosp Univ A Coruna
RECRUITING

A Coruña, 15006, Spain
Hosp. Clinico Univ. de Santiago
RECRUITING

Santiago de Compostela, 15706, Spain
Hosp. Infanta Luisa
RECRUITING

Seville, 41010, Spain
Hosp. Ntra. Sra. de Valme
RECRUITING

Seville, 41014, Spain
Hosp. Univ. Infanta Leonor
RECRUITING

Madrid, 28031, Spain
Hosp. Univ. Marques de Valdecilla
RECRUITING

Santander, 39008, Spain
Hosp. Univ. de Bellvitge
RECRUITING

L'Hospitalet de Llobregat, 08907, Spain
Hosp. Virgen Del Rocio
RECRUITING

Seville, 41013, Spain
Hosp. Virgen Macarena
RECRUITING

Seville, 41009, Spain
Hospital Das Clinicas Da Faculdade De Medicina Da USP
RECRUITING

São Paulo, 05403 900, Brazil
Hospital Kuala Lumpur
RECRUITING

Kuala Lumpur, 50586, Malaysia
Hospital Maisonneuve-Rosemont
RECRUITING

Montreal, Quebec, H1T 2M4, Canada
Hospital Militar Central Cir. My. Dr. Cosme Argerich
RECRUITING

Buenos Aires, C1426, Argentina
Hospital Raja Permaisuri Bainun
RECRUITING

Ipoh, 30450, Malaysia
Hospital Selayang
RECRUITING

Batu Caves, 68100, Malaysia
Hospital Sultan Ismail
RECRUITING

Johor Bahru, 81100, Malaysia
Hospital Sultanah Bahiyah
RECRUITING

Alor Star, 05460, Malaysia
Hospital Tuanku Jaafar
RECRUITING

Seremban, 70300, Malaysia
Hospital Universitario Dr Jose Eleuterio Gonzalez
RECRUITING

Monterrey, 64460, Mexico
Hospital of the University of Occupational and Environmental Health
RECRUITING

Kitakyushu-shi, 807-8556, Japan
Huashan Hospital Fudan University
RECRUITING

Shanghai, 200040, China
IRCCS Policlinico San Matteo
RECRUITING

Pavia, 27100, Italy
ISA - Interdisciplinary Study Association GmbH
RECRUITING

Berlin, 10789, Germany
Indraprastha Apollo Hospital
RECRUITING

New Delhi, 1100776, India
Instituto Medico De Alta Complejidad (IMAC)
RECRUITING

Buenos Aires, B1643CRO, Argentina
Integral Rheumatology And Immunology Specialists
RECRUITING

Plantation, Florida, 33324, United States
Ipswich Hospital
RECRUITING

Ipswich, 4305, Australia
Istituto Clinico Humanitas
RECRUITING

Rozzano, 20089, Italy
JSS Hospital
COMPLETED

Mysuru, 570004, India
Jinhua municipal central hospital
RECRUITING

Jinhua, 321013, China
Joint and Muscle Research Institute
RECRUITING

Charlotte, North Carolina, 28204, United States
Kansai Medical University Hospital
RECRUITING

Hirakata, 573 1191, Japan
Kaohsiung Chang Gung Memorial Hospital
RECRUITING

Kaohsiung City, 83301, Taiwan
Kita-harima Medical Center
COMPLETED

Hyōgo, 6751392, Japan
Klein And Associates M D P A
RECRUITING

Hagerstown, Maryland, 21740, United States
Kocaeli University Medical Faculty
RECRUITING

Kocaeli, 41001, Turkey (Türkiye)
Kyorin University Hospital
RECRUITING

Tokyo, 181 8611, Japan
L K N Arthrocentrum
RECRUITING

Hlučín, 748 01, Czechia
LMK Servicos Medicos S S
RECRUITING

Porto Alegre, 90480 000, Brazil
Linfen Central Hospital
RECRUITING

Linfen, 041000, China
Linyi City People Hospital
RECRUITING

Linyi, 276002, China
MAV Korhaz es Rendelointezet
RECRUITING

Szolnok, 5000, Hungary
MC Ekselsior
COMPLETED

Sofia, 1407, Bulgaria
MICS Centrum Medyczne Torun
RECRUITING

Torun, 87-100, Poland
MICS Centrum Medyczne Warszawa
RECRUITING

Warsaw, 00-874, Poland
MR Medicina Reumatologica
RECRUITING

San Fernando, B1646GHP, Argentina
MUDr Rosypalova s r o
RECRUITING

Ostrava, 708 00, Czechia
Maeshima Rheumatology Clinic
RECRUITING

Ōita, 870 0030, Japan
Malopolskie Badania Kliniczne Sp z o o
RECRUITING

Krakow, 30-002, Poland
Marengo Cims Hospital
RECRUITING

Ahmedabad, 380060, India
Medaudio Optica S R L
RECRUITING

Râmnicu Vâlcea, 247065, Romania
Medical Plus S R O
RECRUITING

Uherské Hradiště, 68601, Czechia
Medizinische Fakultaet Carl Gustav Carus Technische Universitaet Dresden
COMPLETED

Dresden, 01307, Germany
Medizinische Fakultaet Der Albert Ludwigs Universitaet Freiburg
RECRUITING

Freiburg im Breisgau, 79106, Germany
Mie University Hospital
RECRUITING

Tsu, 514 8507, Japan
Multiprofile Hospital for Active Treatment - MHAT Lyulin EAD
RECRUITING

Sofia, 1336, Bulgaria
Multiprofile Hospital for Active Treatment Plovdiv
COMPLETED

Plovdiv, 4003, Bulgaria
NHO Chiba Medical Center Chibahigashi National Hospital
RECRUITING

Chiba, 260-8712, Japan
NZOZ Lecznica MAK MED S C
RECRUITING

Nadarzyn, 05-830, Poland
Nagoya City University Hospital
RECRUITING

Nagoya, 467 8602, Japan
Naiara Alvarez MD Integrative Rheumatology of South TX
SUSPENDED

Harlingen, Texas, 78550, United States
Nanfang Hospital of Southern Medical Hospital
ACTIVE_NOT_RECRUITING

Guangzhou, 510515, China
National Hospital Organization Yokohama Medical Center
RECRUITING

Yokohama, 245-8575, Japan
National Taiwan University Hospital Hsin Chu Branch
RECRUITING

Hsinchu, 300, Taiwan
Necmettin Erbakan Universitesi Tip Fakultesi
RECRUITING

Konya, 42080, Turkey (Türkiye)
New Cross Hospital
RECRUITING

Wolverhampton, WV10 0QP, United Kingdom
Obudai Egeszsegugyi Centrum Kft
COMPLETED

Kaposvár, 7400, Hungary
Omega Research Consultants
RECRUITING

DeBary, Florida, 32713, United States
Osaka Metropolitan University Hospital
RECRUITING

Osaka, 545 8586, Japan
Ospedale S. Maria Della Misericordia
RECRUITING

Udine, 33100, Italy
Ospedale San Raffaele
RECRUITING

Milan, 20132, Italy
Osteo-Medic s.c A. Racewicz, J Supronik
RECRUITING

Bialystok, 15-351, Poland
PV Medical S R O
RECRUITING

Zlín, 76001, Czechia
Peking University Third Hospital
RECRUITING

Beijing, 100191, China
Phramongkutklao Hospital
RECRUITING

Bangkok, 10400, Thailand
Pingxiang People's Hospital
RECRUITING

Pingxiang, 337055, China
Policlinico San Marco
RECRUITING

Catania, 95124, Italy
Porcika Klinika - Vasarhelyi Sarkanyfu Kft.
RECRUITING

Hódmezővásárhely, 6800, Hungary
Pratia Czech s r o
RECRUITING

Prague, 13000, Czechia
Pratia MCM Krakow
RECRUITING

Krakow, 30-727, Poland
Praxis Dr. med. Beate Schwarz - Germany
RECRUITING

Langenau, 89129, Germany
Prince of Wales Hospital
RECRUITING

Hong Kong, 000000, Hong Kong
Public Interest Incorporated Foundation Nipoon Life Saiseikai Nippon Life Hospital
RECRUITING

Osaka, 550 0006, Japan
Qualiclinic Kft
RECRUITING

Budapest, 1134, Hungary
Quantum Medical Center Srl
RECRUITING

Bucharest, 012071, Romania
Queen Elizabeth Hospital
RECRUITING

South Woodville, 5011, Australia
Queen Mary Hospital
RECRUITING

Hong Kong, Hong Kong
RHEUMA s r o
RECRUITING

Břeclav, 690 02, Czechia
RM Pharma Specialists
RECRUITING

Mexico City, 03100, Mexico
Rajavithi Hospital
RECRUITING

Bangkok, 10400, Thailand
Regionshospitalet Godstrup
RECRUITING

Herning, 7400, Denmark
Revita Kft
RECRUITING

Budapest, 1027, Hungary
Revmacentrum MUDr Mostera s r o
RECRUITING

Brno, 615 00, Czechia
Revmatologie s r o
RECRUITING

Brno, 63800, Czechia
Rheumaforschung - Studienambulanz Dr. Wassenberg
COMPLETED

Ratingen, 40878, Germany
Rheumatology Associates of Oklahoma
RECRUITING

Oklahoma City, Oklahoma, 73116, United States
Rheumatology Research Unit
RECRUITING

Maroochydore, 4558, Australia
Rheumazentrum Ruhrgebiet
RECRUITING

Herne, 44649, Germany
Royal Darwin Hospital
RECRUITING

Tiwi, 0810, Australia
Royal Free London NHS Foundation Trust
RECRUITING

Barnet, EN5 3DJ, United Kingdom
Royal North Shore Hospital
RECRUITING

St Leonards, 2065, Australia
S C Delta Health Care S R L
RECRUITING

Bucharest, 014142, Romania
SIDS (Surat Institute of Digestive Sciences) Hospital and Research Centre
RECRUITING

Surat, 395002, India
Sanuki Municipal Hospital
RECRUITING

Sanuki, 7692393, Japan
Saraburi Hospital
RECRUITING

Changwat Sara Buri, 18000, Thailand
Sasebo Chuo Hospital
RECRUITING

Sasebo, 857 1195, Japan
Seattle Rheumatology
RECRUITING

Seattle, Washington, 98104, United States
Second Affiliated Hospital of Soochow University
RECRUITING

Suzhou, 215004, China
Shanghai skin disease hospital
RECRUITING

Shanghai, 200443, China
Shanxi Bethune Hospital
RECRUITING

Taiyuan, 030032, China
Shenzhen People s Hospital
RECRUITING

Shenzhen, 518020, China
Sichuan Provincial Peoples Hospital
RECRUITING

Chengdu, 610072, China
Sir Run Run Shaw Hospital Zhejiang University School of Medicine
RECRUITING

Hangzhou, 310018, China
Siriraj Hospital
RECRUITING

Bangkok, 10700, Thailand
Songklanagarind hospital
RECRUITING

Songkhla, 90110, Thailand
Specderm Poznanska sp j
COMPLETED

Bialystok, 15-375, Poland
Specjalistyczny gabinet dermatologiczny Aplikacyjno Badawczy Marek Brzewski Pawel Brzewski Spolka Cywilna
RECRUITING

Krakow, 30-002, Poland
St Paul Rheumatology PA
RECRUITING

Eagan, Minnesota, 55123, United States
St. Luke's International Hospital
RECRUITING

Chūōku, 104 8560, Japan
Suncoast Clinical Research
RECRUITING

New Port Richey, Florida, 34652, United States
Sushruta Multispeciality Hospital
RECRUITING

Hubballi, 580021, India
Svendborg Hospital Odense University Hospital
RECRUITING

Svendborg, 5700, Denmark
Sydvestjysk Sygehus
RECRUITING

Esbjerg, 6700, Denmark
Szpital Uniwersytecki nr 2 im dr Jana Biziela w Bydgoszczy
RECRUITING

Bydgoszcz, 85-168, Poland
Taipei Veterans General Hospital
RECRUITING

Taipei, 112, Taiwan
The Affiliated Hospital of Guizhou Medical University
RECRUITING

Guiyang, 550004, China
The First Affiliated Hospital of Chongqing Medical University
RECRUITING

Chongqing, 400016, China
The First Affiliated Hospital of Wenzhou Medical University
RECRUITING

Wenzhou, 325000, China
The First Bethune Hospital of Jilin University
RECRUITING

Changchun, 130021, China
The First Hospital of Jiaxing
RECRUITING

Jiaxing, 314001, China
The Second Affiliated Hospital of Nanchang University
RECRUITING

Nanchang, 330008, China
The Second Affiliated Hospital of Xi'an Jiaotong University
RECRUITING

Xi'an, 710006, China
The Waterside Clinic
RECRUITING

Orillia, Ontario, L3V 1T5, Canada
Tohoku University Hospital
RECRUITING

Sendai, 980 8574, Japan
Torbay Hospital-Devon
RECRUITING

Torquay, TQ2 7AA, United Kingdom
Trial Pharma Kft
RECRUITING

Békéscsaba, 5600, Hungary
UMHAT Kaspela
RECRUITING

Plovdiv, 4001, Bulgaria
UMHAT St. Ivan Rilski
RECRUITING

Sofia, 1612, Bulgaria
UT Southwestern
RECRUITING

Dallas, Texas, 75390, United States
Universidade Federal de Minas Gerais UFMG Faculdade de Medicina
RECRUITING

Belo Horizonte, 30130 100, Brazil
Universita Degli Studi di Roma Tor Vergata
RECRUITING

Roma, 00133, Italy
Universitatsklinikum Tubingen
RECRUITING

Tübingen, 72076, Germany
University Hospitals Dorset NHS Foundation Trust
RECRUITING

Christchurch, BH23 2JX, United Kingdom
University of Szeged
RECRUITING

Szeged, 6725, Hungary
Uno Medical Trials Ltd.
RECRUITING

Budapest, 1152, Hungary
Vejle Sygehus
RECRUITING

Vejle, 7100, Denmark
Velocity Clinical Research
RECRUITING

Waco, Texas, 76710, United States
Vital Medical Center Orvosi es Fogaszati Kozpont
RECRUITING

Veszprém, 8200, Hungary
West China Hospital Sichuan University
RECRUITING

Chengdu, 610041, China
Western General Hospital
RECRUITING

Edinburgh, EH4 2XU, United Kingdom
Womens College Hospital
RECRUITING

Toronto, Ontario, M5S 1B1, Canada
Xiangya Hospital Central South University
RECRUITING

Changsha, 410008, China
Zespol Poradni Specjalistycznych Reumed Filia nr 1
RECRUITING

Lublin, 20-607, Poland

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