Which psoriasis cream causes less skin discoloration? new study aims to find out
NCT ID NCT05981118
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study compares two standard psoriasis creams—a steroid and a newer drug called tapinarof—to see which one causes less skin color change after treatment. Forty adults with darker skin types will use one cream daily on their legs for up to 12 weeks. Researchers will track pigmentation changes, redness, and dryness to help doctors choose the best option for reducing lasting marks.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Betamethasone dipropionate 0.05% cream and tapinarof 1% cream
What this could lead to
If successful, this study could help doctors choose a psoriasis treatment that leaves less lasting skin discoloration, especially for people with darker skin tones.
What could go wrong
This is a small, early-phase study with only 40 participants, so results may not apply to everyone. It compares two existing treatments, so no new drug is being tested.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Wake Forest University Health Sciences Department of Dermatology
Winston-Salem, North Carolina, 27157, United States